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Total 317 results found since Jan 2013.

Mesenchymal stem cells for ischemic stroke: progresses and possibilities.
Abstract Stroke is the most common reason of death and quality of life impairments due to neurological deficits in industrialized countries, currently afflicting 15 million people every year, and the numbers are expected to increase, mostly due to population aging. Although some acute phase therapies such as intravenous recombinant tissue plasminogen activator (rt-PA) and more recently endovascular treatment have been identified to improve stroke outcome, these therapies are available only for a small proportion of patients. The social and economic impact of stroke is immense because one of five stroke patient's d...
Source: Current Medicinal Chemistry - February 21, 2016 Category: Chemistry Authors: Ferri AL, Bersano A, Lisini D, Boncoraglio G, Frigerio S, Parati E Tags: Curr Med Chem Source Type: research

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments
Publication date: 15 July 2015 Source:Neuron, Volume 87, Issue 2 Author(s): Paul M. George, Gary K. Steinberg Stroke remains a leading cause of death and disability in the world. Over the past few decades our understanding of the pathophysiology of stroke has increased, but greater insight is required to advance the field of stroke recovery. Clinical treatments have improved in the acute time window, but long-term therapeutics remain limited. Complex neural circuits damaged by ischemia make restoration of function after stroke difficult. New therapeutic approaches, including cell transplantation or stimulation, focus...
Source: Neuron - July 17, 2015 Category: Neuroscience Source Type: research

Cell Therapy for Stroke: Review of Previous Clinical Trials and Introduction of Our New Trials.
In this study, we introduce the preparation of a new clinical trial, the Research on Advanced Intervention using Novel Bone marrow stem cell (RAINBOW) study. The trial will start in 2016, and we hope that it will not only be helpful for treating patients but also for clarifying the therapeutic mechanisms. Moreover, we review stem cell therapeutics as an emerging paradigm in stroke (STEPS) and the guidelines for the development of cell therapy for stroke in the United States as well as introduce the development of new guidelines in Japan. These guidelines are expected to encourage the development of cell therapy for stroke ...
Source: Neurologia Medico-Chirurgica - June 17, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Potential of Exosomes for the Treatment of Stroke.
Abstract Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain...
Source: Cell Transplantation - December 6, 2018 Category: Cytology Authors: Hong SB, Yang H, Manaenko A, Lu J, Mei Q, Hu Q Tags: Cell Transplant Source Type: research

Role of Renal Dysfunction as a Prognostic Factor in Acute Stroke Patients at a Tertiary Hospital in Northeastern Nigeria
Saudi J Kidney Dis Transpl. 2021 Jan-Feb;32(1):199-203. doi: 10.4103/1319-2442.318524.ABSTRACTChronic kidney disease (CKD) and stroke share many common risk factors, and the presence of CKD confers added risk factors for stroke. With increasing interest and understanding of the close relationship between the kidney and the brain, this study aims to assess the prevalence and impact of renal dysfunction on outcomes acute stroke patients. This is a prospective hospital-based study carried out in the neurology unit of University of Maiduguri Teaching Hospital, Maiduguri, northeastern Nigeria. The study population consisted of ...
Source: Saudi Journal of Kidney Diseases and Transplantation - June 19, 2021 Category: Urology & Nephrology Authors: Mohammad Maina Sulaiman Musa Mamman Watila Jummai Shettima Ibrahim Ummate Yakubu Wilberforce Nyandaiti Source Type: research