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Specialty: Pediatrics
Condition: Pregnancy

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Total 23 results found since Jan 2013.

Neonatal arterial ischemic stroke: Which thrombotic biological risk factors to investigate and which practical consequences?
Abstract All biological risk factors that have been previously identified to increase the risk of thrombosis in adults, have also been studied in neonates with arterial Ischemic Stroke (NAIS), but most studies were retrospective and included relatively low numbers of affected children. We therefore could not suggest recommendations with a strong level of evidence and only expert proposals potentially useful for clinical practice will be presented in this text. Despite these limitations, the extensive analysis of published data supported that factor V Leiden (FVL) and increased levels of Lp(a) could be significant ...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Perez T, Valentin JB, Saliba E, Gruel Y Tags: Arch Pediatr Source Type: research

Neonatal Forearm Compartment Syndrome: Look for Cerebral Stroke
A male term newborn presented with a neonatal forearm compartment syndrome together with an ipsilateral cerebral stroke. Pregnancy and delivery were uneventful, except for oligohydramnios. His mother had celiac disease and hypothyroidism. Since birth, he showed a 4-cm bullous-ulcerated lesion on the left volar forearm and elbow fold (, A), with normal pulses, and an ipsilateral upper limb paresis with reduced motility, dropped wrist, no fingers extension, and grasping. Tendon reflexes were normal with Babinski sign bilaterally evident. Radiography showed a mild carpus asymmetry (left left). He had a residual scar on the fo...
Source: The Journal of Pediatrics - November 18, 2013 Category: Pediatrics Authors: Elena Pavlidis, Carlotta Spagnoli, Maddalena Duca, Francesca Ormitti, Cinzia Magnani, Francesco Pisani Tags: Insights and Images Source Type: research

Annelizabeth ’s story: Care that feels like home, close to home
When you’re 5, it’s nice to have a place that feels like a second home. Where there are lots of hugs. And songs. And games. And you can curl up and watch “Frozen,” your favorite movie. For Annelizabeth Jean-Baptiste, a spunky Waltham kindergartener, that place is Boston Children’s Hospital at Waltham. Annelizabeth, or Annie (but never Anna, she says), first came to Boston Children’s at Waltham two weeks after she was born. Her mother Elcie wasn’t expecting that her fourth child would need special care. “It was a difficult pregnancy. I was very excited and relieved when she was born.” But that sense of rel...
Source: Thrive, Children's Hospital Boston - August 29, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Boston Children's at Waltham Dr. Rachael Grace sickle cell disease Source Type: news

A new life for Lynkin after encephalocele surgery
When you meet Lynkin Bell, the first things you notice are her big personality and chubby cheeks. You might also see how she adores her brother Lukis and hamming it up for the camera. But you’d never guess that this playful 14-month-old from Texas wasn’t expected to survive, never mind talk, stand or play peekaboo like a pro. And yet, thanks to her parents’ faith and persistence — and surgery at Boston Children’s Hospital — Lynkin can do all those things, and lots more, with the gusto befitting any toddler her age. “It’s a miracle,” says Kaylen Gaston, Lynkin’s mom. “We were told so many times she wou...
Source: Thrive, Children's Hospital Boston - April 24, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Diseases & Conditions Our Patients’ Stories Craniofacial Program Dr. John Meara Dr. Mark Proctor encephalocele Source Type: news

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

How to use... lupus anticoagulants
Introduction Lupus anticoagulants (LA) were first detected in patients with systemic lupus erythematosus (SLE) in 1952 by Conley and Hartmann.1 They identified patients in whom the activated partial thromboplastin time (APTT) was prolonged and which did not correct on the addition of normal plasma. Although Conley and Hartmann's original description was in association with a haemorrhagic disorder, subsequent reports from the 1960s highlighted patients with thrombotic events in the presence of LA.2 The term ‘lupus anticoagulant’ was introduced by Feinstein and Rapaport in 1972.3 It has, however, caused some conf...
Source: Archives of Disease in Childhood - Education and Practice - March 14, 2013 Category: Pediatrics Authors: Sen, E. S., Beresford, M. W., Avcin, T., Ramanan, A. V. Tags: Liver disease, Immunology (including allergy), Hepatitis and other GI infections, Travel medicine, Epilepsy and seizures, Headache (including migraine), Stroke, Pregnancy, Reproductive medicine, Rheumatology Interpretations Source Type: research

Negative behaviors and events during pregnancy impact neonates’ birth characteristics
A growing body of literature identifies the negative impact of certain maternal behaviors (eg, smoking, substance abuse) on neonatal health (eg, preterm birth, low birth rate, smallness for gestational age). Smallness for gestational age is in turn associated with childhood developmental and behavioral problems, as well as excessive rates in adults of cardiovascular disease, stroke, non-insulin dependent diabetes mellitus, adiposity, and metabolic syndrome.
Source: The Journal of Pediatrics - August 1, 2013 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Hypothermia did not improve mortality or disability in severe traumatic brain injury
Study design Design: Randomised controlled trial (RCT). Allocation: Concealed web based algorithm to stratified by study site and age. Blinding: Treating doctors not masked—investigators assessing outcome were masked. Study question Setting: Multinational, multicentre paediatric intensive care unit—75% patients from three paediatric intensive care units (Davis, California; Dallas, Texas; Pittsburgh, Pennsylvania) in USA. Patients: Age 0–17 years non-penetrating brain injury; Glasgow coma scale (GCS) score 3–8 (motor score <6), available for randomisation within 6 h of injury. Excluded i...
Source: Archives of Disease in Childhood - Education and Practice - May 14, 2014 Category: Pediatrics Authors: Tasker, R. C. Tags: Clinical trials (epidemiology), Epidemiologic studies, Coma and raised intracranial pressure, Neurological injury, Stroke, Hypertension, Pregnancy, Reproductive medicine, Child health, Neonatal and paediatric intensive care, Neonatal health, Trauma, Injur Source Type: research

Early mother-infant relationships after cardiac surgery in infancy
Conclusions Most mothers report a positive relationship with their infant following cardiac surgery but almost a quarter have difficulties forming a strong emotional tie. Clinical care (including prenatal) of the infant with congenital heart disease requiring surgery should include screening, assessment and appropriate referral for early intervention if mothers are struggling to form a bond with their infant.
Source: Archives of Disease in Childhood - June 12, 2014 Category: Pediatrics Authors: Jordan, B., Franich-Ray, C., Albert, N., Anderson, V., Northam, E., Cochrane, A., Menahem, S. Tags: Congenital heart disease, Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Child and adolescent psychiatry (paedatrics), Mood disorders (including depression), Screening (epidemiology), Screening (public health) Original article Source Type: research

Cerebral ultrasound abnormalities in offspring of women with C677T homozygous mutation in the MTHFR gene: a prospective study.
CONCLUSIONS: Our data confirmed a high incidence of cerebral abnormalities in neonates born to women with C677T homozygous mutation in the MTHFR gene. cUS at birth proved to be an effective screening tool or a diagnostic test, that should be routinely performed in babies born to mothers with known thrombotic predisposition. PMID: 24974211 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - June 28, 2014 Category: Pediatrics Authors: Pogliani L, Cerini C, Penagini F, Duca P, Mameli C, Zuccotti GV Tags: World J Pediatr Source Type: research

What is the Remission Rate for Antithyroid Drug Treatment for Hyperthyroidism in Children?
Discussion The thyroid gland secrets two hormones – T4 which is a prohormone and T3 which is the biologically active hormone. Receptors for T3 are found in nearly all body tissues. T3 regulates metabolism and energy production. Organs most affected are the heart, liver and central nervous system as well as growth of the fetus and child. Hyperthyroidism is common with a prevalence rate of about 1-2% for women and 0.2% for men. The most common cause of thyrotoxicosis is Grave’s disease where autoantibodies to thyroid stimulating hormone (TSH) exist. These autoantibodies attach to thyroid tissue TSH receptors and...
Source: PediatricEducation.org - January 26, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Ella’s story: Two rare diseases and the NICU roller coaster ride
“Everyone tells you that the NICU is a roller coaster ride. What they don’t tell you is that it’s a customized roller coaster ride just for you. You never know what’s coming at you next,” says Carrie Shea, whose daughter Ella spent her first three months of life in Boston Children’s Hospital NICU. Today, Ella is a “remarkably normal little girl,” says Carrie. It’s quite a feat for the three-year-old who was born with GACI (generalized arterial calcification of infancy), an extremely rare condition with an 85 percent mortality rate, and diagnosed with PKU (phenylketonuria), a second rare genetic disorder, ...
Source: Thrive, Children's Hospital Boston - March 5, 2015 Category: Pediatrics Authors: Lisa Fratt Tags: Our patients’ stories Source Type: news

What Are Common Inherited Thrombophilias?
Discussion Thrombophilia is the increased risk of thromboembolic disease due to a disorder. Thrombophilia can be inherited or acquired (such as antiphospholipid syndrome). The risk of thromboembolic events is much lower in children than adults. At-risk patients should avoid: Dehydration Sitting for prolonged time periods during travel Obesity Smoking Estrogen containing oral contraceptives Common inherited thrombophilias include: Prothrombin (Factor II mutation) Second most common Genetics: 1-2% prevalence is variable depending on location and ethnic background. Cause: Abnormal point mutation of the prothrombin gene t...
Source: PediatricEducation.org - May 25, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Renin-Angiotensin System Blocker Fetopathy
Chronic hypertension in pregnant women is associated with significant maternal and fetal morbidity and mortality, and is thought to complicate approximately 5% of the 4 million pregnancies in the US annually.1 Pregnant women with chronic hypertension are at risk for developing adverse complications, such as maternal preeclampsia, stroke, renal failure, and death.2 In addition, adverse fetal outcomes, such as intrauterine growth restriction, preterm birth, and death, are more likely among pregnant women with chronic hypertension than those without.
Source: The Journal of Pediatrics - August 5, 2015 Category: Pediatrics Authors: Janet D. Cragan, Bessie A. Young, Adolfo Correa Tags: Editorial Source Type: research

Experience Journal: Growing up with cerebral palsy
Cerebral palsy (CP) is the most common physical disability of childhood. The term CP is an umbrella term for a group of disorders that affect body movement and posture as a result of damage to a baby’s developing brain. There are many causes for CP, but all occur either during pregnancy, birth or shortly after birth. Common causes include differences in brain development, infection or stroke. Oxygen deprivation is accountable for only a small percentage of cases of CP; often, the cause is unknown. Although CP is a lifelong condition that can’t be reversed, children with the diagnosis can lead rich, fulfilling lives wit...
Source: Thrive, Children's Hospital Boston - March 18, 2016 Category: Pediatrics Authors: Erin Horan Tags: Experience Journal Cerebral Palsy Program Source Type: news