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Long-term association of pregnancy and maternal brain structure: the Rotterdam Study
AbstractThe peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women ’s lives. Notably, pregnancy and childbirth have been associated with short-term structural and functional changes in the maternal human brain. Yet the long-term effects of pregnancy on maternal brain structure remain unknown. We investigated a large population-based cohort to examine the asso ciation between parity and brain structure. In total, 2,835 women (mean age 65.2 years; all free from dementia, stroke, and cortical brain infarcts) from the Rotterdam Study underwent magnetic resonance i...
Source: European Journal of Epidemiology - January 6, 2022 Category: Epidemiology Source Type: research

Impact of Male Origin Microchimerism on Cardiovascular Disease in Women: A Prospective Cohort Study.
Abstract Increasing parity is associated with an increased risk of ischemic heart disease (IHD) and stroke in women. This is likely attributed to biological responses of pregnancy. Male cells of presumed fetal origin are commonly present in women years after pregnancy-a phenomenon termed male origin microchimerism. Here, we investigated whether male origin microchimerism was associated with risk of IHD and ischemic stroke in women. We evaluated the association between male origin microchimerism and ischemic events in a cohort of 766 Danish women enrolled in the Diet, Cancer and Health cohort during 1993-1997 when ...
Source: Am J Epidemiol - November 13, 2020 Category: Epidemiology Authors: Hallum S, Gerds TA, Sehested TSG, Jakobsen MA, Tjønneland A, Kamper-Jørgensen M Tags: Am J Epidemiol Source Type: research

Impact of Male-Origin Microchimerism on Cardiovascular Disease in Women: A Prospective Cohort Study
In this study, we investigated whether MOM was associated with risk of IHD and ischemic stroke in women. We evaluated the association between MOM and ischemic events in a cohort of 766 Danish women enrolled in the Diet, Cancer and Health cohor t during 1993–1997 when aged 50–64 years. Of these women, 545 (71.2%) tested positive for MOM through targeting of the Y chromosome (DYS14 DNA sequence) in their blood. Multiple Cox regression models were used to calculate hazard ratios with 95% confidence intervals. We found that MOM was associated with a significantly reduced rate of IHD (hazard ratio  = 0.44, 95% confidence ...
Source: American Journal of Epidemiology - November 13, 2020 Category: Epidemiology Source Type: research

Air pollution and cardiovascular events at labor and delivery: a case-crossover analysis.
CONCLUSIONS: Cardiovascular events at labor/delivery merit more attention in relation to air pollution. PMID: 28552468 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - May 12, 2017 Category: Epidemiology Authors: Ha S, Männistö T, Liu D, Sherman S, Ying Q, Mendola P Tags: Ann Epidemiol Source Type: research

Invited Commentary: Hypertension During Pregnancy and Offspring Microvascular Structure--Insights From the Retinal Microcirculation
Human clinical studies as well as laboratory animal studies demonstrate that offspring of pregnancies affected by common complications, such as preeclampsia and preterm birth, display developmental phenotypes that relate distinctly to the pregnancy disorder. Several studies have now found microvascular differences in offspring of hypertensive pregnancies, and there is interest in whether these may underlie epidemiologic associations between gestational hypertension and a higher risk of hypertension and stroke in the offspring. The retinal circulation provides a unique window into microvascular structure, of likely relevanc...
Source: American Journal of Epidemiology - October 30, 2016 Category: Epidemiology Authors: Huckstep, O., Lewandowski, A. J., Leeson, P. Tags: RESEARCH-ARTICLE Source Type: research

CDC National Health Report: Leading Causes of Morbidity and Mortality and Associated Behavioral Risk and Protective Factors-United States, 2005-2013.
This report reviews population health in the United States and provides an assessment of recent progress in meeting high-priority health objectives. The health status indicators described in this report were selected because of their direct relation to the leading causes of death and other substantial sources of morbidity and mortality and should be the focus of prevention efforts. REPORTING PERIOD COVERED: Data are reported starting in 2005 (or the earliest available year since 2005) through the current data year. Because data sources and specific indicators vary regarding when data are available, the most recent yea...
Source: MMWR Surveill Summ - October 31, 2014 Category: Epidemiology Authors: Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA Tags: MMWR Surveill Summ Source Type: research