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Total 208 results found since Jan 2013.
Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research
An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis
Appl Biochem Biotechnol. 2023 Jul 27. doi: 10.1007/s12010-023-04658-9. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis and develops resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to provide a comprehensive defense. So, it is crucial to maintain the immunological response to eliminate tuberculosis. Our previous in silico study reported five uncharacterized proteins as potential vaccine antigens. In this article, we considered the uncharacterized Mtb H37Rv regions of difference (RD-2) Rv1987 protein as a promising vaccine candidat...
Source: Applied Biochemistry and Biotechnology - July 27, 2023 Category: Biochemistry Authors: Aregitu Mekuriaw Arega Ajit Kumar Dhal Kali Prasad Pattanaik Sasmita Nayak Rajani Kanta Mahapatra Source Type: research
Eleven science stories likely to make big news in 2023
As the COVID-19 pandemic enters its fourth year as a global health emergency, researchers will continue pushing to help make the disease manageable and ordinary. They will track hundreds of subvariants of Omicron, the highly transmissible but seemingly less lethal strain of SARSCoV-2 that dominated in 2022. Virologists will watch the virus’ evolution this year to see whether it has finally slowed or a more dangerous variant pops up, evading much of the immunity that humanity has built up to previous ones. Vaccine researchers hope to develop new shots that provide broad protection against a variety of coronaviruses. Ano...
Source: ScienceNOW - January 4, 2023 Category: Science Source Type: news
In vitro and in vivo Evidence on Intra-tumor Injection of Allogeneic Serum for Immunotherapy in a Mouse Model of Colon Cancer
Iran J Allergy Asthma Immunol. 2022 Oct 26;21(5):549-560. doi: 10.18502/ijaai.v21i5.11042.ABSTRACTIt is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected. On the basis of transfusion reaction and transplantation immunology, we hypothesized that allogeneic serum can inhibit tumor growth when injected intra-tumor. Initially, an in vitro cytotoxicity test was conducted using the C57BL/6 serum (intact or decomplemented) in combination with the BALB/c-originating CT26 cell line. The CT26 cell line was used to esta...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Erfan Basirat Danial Dehghan Ardeshir Abbasi Nafiseh Pakravan Source Type: research
