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New Onset Atrial Fibrillation Is Associated with Elevated Galactic-3 Levels
Background: Atrial fibrillation (AF) is associated with increased risk of stroke and cardiac mortality. Atrial remodelling and fibrosis have been suggested to participate in the pathogenesis of AF. Galectin-3 is a secreted protein that has regulatory roles in inflammation, fibrosis and tissue repair. Clinical studies have reported increased circulating galectin 3 levels and cardiac remodelling. Galectin-3 levels have been shown to predict atrial remodelling and incidence of AF. In the current investigation, we tested the hypothesis that Galectin-3 release occurs selectively in the acute phase of AF.
Source: Heart, Lung and Circulation - July 27, 2016 Category: Cardiology Authors: D. Chen, N. Procter, V. Goh, S. Liu, S. Chua, B. Assadi-Khansari, J. Horowitz, A. Sverdlov, D. Ngo Tags: 187 Source Type: research

Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical Indications: A Case Series Analysis
Conclusions Rivaroxaban is a valuable treatment option for patients with biological prostheses, repaired mitral valves, or a tubular aortic graft in order to prevent thromboembolic complications.
Source: Clinical Drug Investigation - July 10, 2016 Category: Drugs & Pharmacology Source Type: research

Current knowledge on assessing the effects of and managing bleeding and urgent procedures with direct oral anticoagulants.
CONCLUSION: With or without reversal agents, patients may require supportive management such as mechanical pressure, volume support, transfusions of blood products, and, depending on the situation, surgery to repair the bleeding source. Specific reversal agents are currently under development or have recently been approved for the urgent management of bleeding events or the facilitation of invasive procedures in patients receiving DOACs. PMID: 27147455 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - May 6, 2016 Category: Drugs & Pharmacology Authors: Dager W, Hellwig T Tags: Am J Health Syst Pharm Source Type: research

Early Experiences with the Endovascular Repair of Ruptured Descending Thoracic Aortic Aneurysm.
CONCLUSION: TEVAR for rDTAA was associated with favorable early mortality and morbidity outcomes. However, early reintervention should be considered if persistent endoleak occurs. PMID: 27064672 [PubMed - as supplied by publisher]
Source: Korean Journal of Thoracic and Cardiovascular Surgery - April 12, 2016 Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Early and long-term outcomes of minimally invasive mitral valve surgery through right minithoracotomy: a 10-year experience in 1604 patients
Conclusions: Minimally invasive mitral valve surgery is a safe and reproducible approach associated with low mortality and morbidity, high rate of mitral valve repair and excellent late results.
Source: Journal of Cardiothoracic Surgery - December 7, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Mattia GlauberAntonio MiceliDaniele CanaruttoAntonio LioMichele MurziDaniyar GilmanovMatteo FerrariniPier FarnetiEugenio QuainiMarco Solinas Source Type: research

Intermediate and long-term cognitive effects in older adults secondary to cardiovascular procedures is uncommon but current evidence is insufficient
Commentary on: Fink HA, Hemmy LS, MacDonald R, et al. Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review. Ann Intern Med 2015;163:107–17 . Context Cardiovascular procedures are common in the older population.1 There is suspicion that these procedures may have a negative outcome on cognition.2 However, further research has indicated that there may have been pre-existing cognitive deficits as cognitive impairment is common in the older population.3 This systematic review examines the evidence of the relationship of coronary and carotid revascularisation, ...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Charles, L. Tags: Health policy, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Dementia, Stroke, Interventional cardiology, Memory disorders (psychiatry), Radiology, Clinical diagnostic tests, Health service research Aetiology/Harm Source Type: research

What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies
Conclusions Minimally invasive mitral valve surgery is a safe and comparable alternative to standard sternotomy in patients at high risk, with similar early mortality and repair rate and better postoperative outcomes, although a longer cardiopulmonary bypass time is required.
Source: The Annals of Thoracic Surgery - October 24, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Reply Primum Non Nocere: First Do No Harm
Discussion section, the strong correlation shown in Figure 4A would not be possible if variability of afterload was an important consideration.3.If aortic regurgitation were underestimated by MRI, it would lead to an overestimation of mitral regurgitant volume, not an underestimation.4.We do not believe our study shows that pre-surgical left ventricular (LV) volumes predict recovery of LV end-diastolic volume (EDV) post-surgery. For example, in Table 4, patient 29 had mild mitral regurgitation (MR) and an end-diastolic diameter (EDD) of 6.2 cm, whereas patient 38 had severe MR and an EDD of 5.3 cm. Our study shows that ...
Source: Journal of the American College of Cardiology - July 20, 2015 Category: Cardiology Source Type: research

How to define valvular atrial fibrillation?
Abstract Atrial fibrillation (AF) confers a substantial risk of stroke. Recent trials comparing vitamin K antagonists (VKAs) with non-vitamin K antagonist oral anticoagulants (NOACs) in AF were performed among patients with so-called "non-valvular" AF. The distinction between "valvular" and "non-valvular" AF remains a matter of debate. Currently, "valvular AF" refers to patients with mitral stenosis or artificial heart valves (and valve repair in North American guidelines only), and should be treated with VKAs. Valvular heart diseases, such as mitral regurgitation, aortic stenosis (AS) and aortic insufficiency, do...
Source: Archives of Cardiovascular Diseases - July 13, 2015 Category: Cardiology Authors: Fauchier L, Philippart R, Clementy N, Bourguignon T, Angoulvant D, Ivanes F, Babuty D, Bernard A Tags: Arch Cardiovasc Dis Source Type: research

Long-Term Outcomes of the Maze Procedure Combined With Mitral Valve Repair: Risk of Thromboembolism Without Anticoagulation Therapy.
CONCLUSIONS: Adopting appropriate selection criteria for discontinuing anticoagulation therapy, the majority of patients receiving concomitant mitral repair and the Maze procedure can discontinue warfarin with excellent long-term safety profiles. PMID: 26116476 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Hwang SK, Yoo JS, Kim JB, Jung SH, Choo SJ, Chung CH, Lee JW Tags: Ann Thorac Surg Source Type: research

Long-Term Outcomes of the Maze Procedure Combined With Mitral Valve Repair: Risk of Thromboembolism Without Anticoagulation Therapy
Conclusions Adopting appropriate selection criteria for discontinuing anticoagulation therapy, the majority of patients receiving concomitant mitral repair and the Maze procedure can discontinue warfarin with excellent long-term safety profiles.
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Rivaroxaban in the Prevention of Stroke and Systemic Embolism in Patients with Non-Valvular Atrial Fibrillation: Clinical Implications of the ROCKET AF Trial and Its Subanalyses
Abstract Atrial fibrillation (AF) is an increasingly common cause of stroke and systemic embolism. While warfarin has been the mainstay of stroke prevention in patients with AF, newer novel oral anticoagulant medications are now available. Rivaroxaban, a direct factor Xa inhibitor with a rapid onset and offset after oral administration, offers potential advantages over warfarin, predominantly due to its predictable pharmacokinetics across wide patient populations. It requires no coagulation monitoring, and only two different doses are needed (20 mg daily for patients with normal renal function and 15 mg daily in...
Source: American Journal of Cardiovascular Drugs - June 11, 2015 Category: Cardiology Source Type: research

Minimally Invasive Port Access Approach for Reoperations on the Mitral Valve
Conclusions The port access approach can be safely adopted for reoperations on the MV without compromising postoperative mortality or MV function.
Source: The Annals of Thoracic Surgery - May 12, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

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