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Excessive supraventricular ectopic activity and future onset of atrial fibrillation in patients with cryptogenic stroke
Although atrial fibrillation (AF) is a leading preventable cause of ischemic stroke,1,2 after the initial evaluation, approximately 30% of all stroke events are finally characterised as cryptogenic.3,4 However, nowadays with the use of prolonged cardiac rhythm monitoring, studies exist to reveal the existence of silent, subclinical AF in those patients, or even the presence of excessive ectopic atrial activity that may precede it.5,6 In particular, such methods can detect and quantify premature atrial complexes (PACs) and short supraventricular runs (SVRs), which, up until recently, have been considered benign electrophysiological phenomena.
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2022 Category: Neurology Authors: Christos Gogos, Elias Zarvalis, Panteleimon Pantelidis, Foteini Davora, Asterios Karakanas, Dimitrios Pitetzis, Nikolaos Stamatiadis, Vasileios Moschovidis, Melani Konstantinidou, Evangelos Oikonomou, Georgia Deretzi, Jobst Rudolf, Ioannis Styliadis Source Type: research

O-016 Outcomes after endovascular mechanical thrombectomy for low national institutes of health stroke scale (NIHSS): a multicenter study
ConclusionsMT is an effective and safe treatment for appropriately selected ischemic stroke patients presenting with low NIHSS. Diabetes and prior stroke are predictors of functional dependence at 90 days, and prior stroke is also associated with mortality, suggesting that MT should be offered judiciously to patients with these risk factors. Our findings signal the need for a randomized trial comparing MT versus medical management for LVO patients with low NIHSS.Disclosures I. Abecassis: 2; C; IschemaView (Rapid), Remedy Robotics. E. Almallouhi: None. R. Chalhoub: None. S. Kassab: None. E. Bass: None. D. Ding: None. I. Mai...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Abecassis, I., Almallouhi, E., Chalhoub, R., Kassab, S., Bass, E., Ding, D., Maier, I., Psychogios, M., Liman, J., Alawieh, A., Wolfe, S., Arthur, A., Kan, P., Kim, J., De Leacy, R., Osbun, J., Jabbour, P., Grossbereg, J., Park, M., Mascitelli, J., Levitt Tags: SNIS 19th annual meeting oral abstracts Source Type: research

Serum circulating sirtuin 6 as a novel predictor of mortality after acute ischemic stroke
In this study, we aimed at evaluating the prognostic value of serum SIRT6 levels in patients with acute ischemic stroke (AIS). Serum levels of SIRT6, collected within 72 h from symptom-onset, were measured in 317 consecutively enrolled AIS patients from the COSMOS cohort. The primary endpoint of this analysis was 90-day mortality. The independent prognostic value of SIRT6 was assessed with multivariate logistic and Cox proportional regression models. 35 patients (11%) deceased within 90-day follow-up. After adjustment for established risk factors (age, NIHSS, heart failure, atrial fibrillation, and C reactive protein), SIR...
Source: Atherosclerosis - November 28, 2022 Category: Cardiology Authors: Luca Liberale Stefano Ministrini Markus Arnold Yustina M Puspitasari Thomas Pokorny Georgia Beer Natalie Scherrer Juliane Schweizer Mirjam Christ-Crain Fabrizio Montecucco Giovanni G Camici Mira Katan Kahles Source Type: research

Abstract 009: The Impact of Participation in a Telestroke Network on In-hospital Mortality in Georgia Session Title: Abstract Oral Session: General
Conclusions: Acute ischemic stroke patients admitted in hospitals participating in a telestroke program had a more pronounced reduction in in-hospital mortality. However, telestroke coverage did not alter the effect of nighttime admission on in-hospital mortality.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Zhang, D., Ido, M. S., Shi, L., Green, D. Tags: Session Title: Abstract Oral Session: General Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Genes, Vol. 11, Pages 438: Interindividual Variability of Apixaban Plasma Concentrations: Influence of Clinical and Genetic Factors in a Real-Life Cohort of Atrial Fibrillation Patients
Conclusions: Pharmacokinetic parameters are influenced by several clinical factors of which renal function is the major determinant. Plasma concentrations measured in women had higher values than those measured in men, and heart failure was associated with decreased plasma levels of apixaban.
Source: Genes - April 16, 2020 Category: Genetics & Stem Cells Authors: Adela-Nicoleta Ro şian Ştefan Horia Roşian Bela Kiss Maria Georgia Ştefan Adrian Pavel Trifa Camelia Diana Ober Ovidiu Anchidin Anca Dana Buzoianu Tags: Article Source Type: research

Impact of comorbid conditions on disease-specific quality of life in older men and women with atrial fibrillation
ConclusionsAmong older persons with AF, while cardiometabolic diseases were highly prevalent, musculoskeletal conditions exerted the greatest impact on patients ’ disease-specific QoL. Understanding the extent of impairment in QoL due to underlying comorbidities provides an opportunity to develop interventions targeted at diseases that may cause significant impairment in QoL.
Source: Quality of Life Research - July 10, 2020 Category: Health Management Source Type: research