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Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research

What Is New in Low Gradient Aortic Stenosis: Surgery, TAVR, or Medical Therapy?
AbstractBackgroundA significant proportion of patients with aortic stenosis (AS) have discordance in severity by mean gradient/peak velocity and aortic valve area. Low gradient aortic stenosis (LG-AS) is defined when the aortic valve area is<  1 cm2 consistent with severe AS and mean aortic gradient is<  40 mmHg consistent with non-severe AS. LG-AS represents a diagnostic and therapeutic challenge.Purpose of ReviewTo summarize the different categories, diagnosis, management, and prognosis of LG-AS. LG-AS is classified as classical (ejection fraction (EF)<  50%, indexed stroke volume (SVi) <  35 ml/...
Source: Current Cardiology Reports - July 8, 2020 Category: Cardiology Source Type: research

Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: An echocardiographic and computed tomography study.
CONCLUSIONS: The AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond the haemodynamic and anatomical severity of AS influence the AT/ET ratio, including LV geometry, function and systolic blood pressure. These findings should be considered when assessing the AT/ET ratio in patients with AS and preserved LVEF. PMID: 31402281 [PubMed - as supplied by publisher]
Source: Archives of Cardiovascular Diseases - August 7, 2019 Category: Cardiology Authors: Altes A, Sochala M, Attias D, Dreyfus J, Bohbot Y, Toledano M, Macron L, Renard C, Chadha G, Truffier A, Guerbaai RA, Ennezat PV, Graux P, Tribouilloy C, Maréchaux S Tags: Arch Cardiovasc Dis Source Type: research

Factors associated with the ratio of acceleration time to ejection time in patients with aortic stenosis: An echocardiographic and computed tomography study
ConclusionAT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond hemodynamic and anatomic severity of AS influence AT/ET ratio including LV geometry, function and SBP. These findings should be considered when assessing AT/ET in patients with AS and preserved LVEF.
Source: Archives of Cardiovascular Diseases Supplements - June 7, 2019 Category: Cardiology Source Type: research

Paradoxical aortic stenosis: A systematic review
Publication date: Available online 31 March 2017 Source:Revista Portuguesa de Cardiologia (English Edition) Author(s): Rita Cavaca, Rogério Teixeira, Maria João Vieira, Lino Gonçalves Aortic stenosis (AS) is a complex systemic valvular and vascular disease with a high prevalence in developed countries. The new entity “paradoxical low-flow, low-gradient aortic stenosis” refers to cases in which patients have severe AS based on assessment of aortic valve area (AVA) (≤1 cm2) or indexed AVA (≤0.6 cm2/m2), but paradoxically have a low mean transvalvular gradient (&lt;40 mmHg) and a low stroke volume index (≤35...
Source: Revista Portuguesa de Cardiologia - March 31, 2017 Category: Cardiology Source Type: research

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction Heart Failure
Conclusion Increased stiffness is the major early pathological process that predisposes to congestive heart failure without abnormalities in systolic function and relaxation in a clinically relevant animal model of aortic stenosis.
Source: JAHA:Journal of the American Heart Association - May 20, 2015 Category: Cardiology Authors: Ishikawa, K., Aguero, J., Oh, J. G., Hammoudi, N., A. Fish, L., Leonardson, L., Picatoste, B., Santos-Gallego, C. G., M. Fish, K., Hajjar, R. J. Tags: Heart Failure Source Type: research