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Specialty: Internal Medicine
Condition: Alcoholism

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Total 68 results found since Jan 2013.

Ischemic Stroke in Young Adults and Preexisting Psychiatric Disorders: A Nationwide Case–Control Study
Abstract: Previous studies showed that psychiatric disorders such as major depression, bipolar disorders, and alcohol misuse are associated with an increased risk of ischemic stroke. However, the link between psychiatric disorders and stroke in the young population is rarely investigated. Using the Taiwan National Health Insurance Research Database, 2063 young adults aged between 18 and 45 years with ischemic stroke and 8252 age- and sex-matched controls were enrolled in our study between 1998 and 2011. Participants who had preexisting psychiatric disorders were identified. After adjusting for preexisting physical disorder...
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Alcohol and cardiovascular diseases: where do we stand today?
Abstract For centuries, multiple medical risks of heavy alcohol drinking have been evident with simultaneous awareness of a less harmful or sensible drinking limit. The increased risks of heavy drinking, defined as three or more standard‐sized drinks per day, are both cardiovascular (CV) and non‐CV. The CV risks include the following: (i) alcoholic cardiomyopathy (ACM), (ii) systemic hypertension, (iii) atrial arrhythmias, (iv) haemorrhagic stroke and, probably, ischaemic stroke. By contrast, modern epidemiological studies have shown lower morbidity and mortality amongst light–moderate drinkers, due mostly to a reduc...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: A. L. Klatsky Tags: Review Source Type: research

No association between adherence to the healthy Nordic food index and cardiovascular disease amongst Swedish women: a cohort study
ConclusionThe present results do not support an association between a healthy Nordic food index and risk of cardiovascular disease in Swedish women. There was also no effect modification by alcohol intake, BMI or age. Our finding of an interaction with smoking status requires reproduction.
Source: Journal of Internal Medicine - May 19, 2015 Category: Internal Medicine Authors: N. Roswall, S. Sandin, R. Scragg, M. Löf, G. Skeie, A. Olsen, H.‐O. Adami, E. Weiderpass Tags: Original Article Source Type: research

Bleeding risk, physical functioning and non-use of anticoagulation among patients with stroke and atrial fibrillation
Conclusion: It appears that in this sample, post-stroke anticoagulation decisions appear to be made based on clinical factors associated with bleed risk and motor deficits or physical functioning. However, opportunities may exist for improving clinician documentation of specific reasoning for non-anticoagulation prescription.
Source: QJM - February 23, 2015 Category: Internal Medicine Authors: Schmid, A. A., Ofner, S., Shorr, R. I., Williams, L. S., Bravata, D. M. Tags: Original papers Source Type: research

Risk of warfarin-associated intracerebral haemorrhage after ischaemic stroke is low and unchanged during the 2000s
Commentary on: Asberg A, Erisksson M, Henriksson KM, et al.. Warfarin-associated intracerebral hemorrhage after ischemic stroke. Stroke 2014;45:2118–20. Context Since its isolation during the early half of the 20th century from the mouldy hay responsible for ‘sweet clover disease’ in cattle, warfarin has become the most widely used oral anticoagulant.1 Indications include atrial fibrillation (AF), mechanical prosthetic valves and venous thromboembolism treatment.2 Warfarin reduces stroke risk in patients with AF by nearly two-thirds; AF accounts for 20% of ischaemic strokes, which tend to be more severe t...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Ruland, S., Biller, J. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Alcohol-related disorders, Drugs misuse (including addiction), Arrhythmias, Alcohol, Health education Aetiology/Harm Source Type: research

Mendelian randomisation meta-analysis sheds doubt on protective associations between 'moderate' alcohol consumption and coronary heart disease
Commentary on: Holmes M, Dale C, Zuccolo L, et al.. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ 2014;349:g4164. Context A protective association between low-dose alcohol and risk of coronary heart disease (CHD) has been suggested by meta-analyses of observational studies and experimental studies. Observational studies are, however, vulnerable to residual confounding and selection bias. Compared with observational studies, the Mendelian randomisation (MR) approach can mitigate confounding, is immune to reverse causation, and is consistent...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Chikritzhs, T. N., Naimi, T. S., Stockwell, T. R., Liang, W. Tags: Genetics, Drugs: cardiovascular system, Stroke, Hypertension, Ischaemic heart disease, Alcohol, Health education Aetiology/Harm Source Type: research

Long-term supplementation with multivitamins and minerals did not improve male US physicians' cardiovascular health or prolong their lives
Commentary on: Sesso HD, Christen WG, Bubes V, et al.. Multivitamins in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2012;308:1751–60. Context Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Behavioural risk factors, including tobacco use, physical inactivity, unhealthy diet and the harmful use of alcohol, are estimated to be responsible for about 80% of coronary heart disease and cerebrovascular disease.1 Until 2000, observational studies found inverse associations between vitamin intake and CVD outcomes....
Source: Evidence-Based Medicine - November 21, 2013 Category: Internal Medicine Authors: Ebbing, M., Vollset, S. E. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Diet, Ischaemic heart disease Therapeutics Source Type: research

In recently postmenopausal women, HRT reduced a composite of death, MI, or heart failure at 10 years.
CONCLUSION In recently postmenopausal women, hormone replacement therapy reduced a composite of death, myocardial infarction, or heart failure after 10 years of therapy and an additional 6 years of follow-up.Hormone replacement therapy (HRT) vs no HRT in recently postmenopausal women†OutcomesEvent ratesAfter 10 y of therapyHRTNo HRTRRR (95% CI)NNT (CI)Death, MI, or HF‡3.2%6.5%50% (11 to 72)31 (22 to 144)At 16 yDeath, MI, or HF§6.6%11%37% (4 to 59)26 (17 to 251)†HF = heart failure; MI = myocardial infarction; other abbreviations defined in Glossary. RRR, NNT, and CI calculated from event rates and hazard ratios in ar...
Source: Annals of Internal Medicine - February 19, 2013 Category: Internal Medicine Authors: Cheung AM Tags: Ann Intern Med Source Type: research