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In vitro study about prevention of vascular reocclusion by low intensity ultrasonic irradiation
Drug Discov Ther. 2022 Oct 9. doi: 10.5582/ddt.2022.01064. Online ahead of print.ABSTRACTFor the treatment of acute ischemic stroke, the current standard of care is thrombolysis by the administration of intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA). Although this approach is proven to be effective, reocclusion within 24 hours occurs in about 20% of patients who receive recanalization by rt-PA. In addition, the administration of anticoagulants within 24 hours after IV rt-PA increases the risk of intracranial hemorrhage; therefore, treatment with anticoagulants is contraindicated in this population. ...
Source: Drug Discoveries and Therapeutics - October 10, 2022 Category: Drugs & Pharmacology Authors: Yoshikazu Sawaguchi Zuojun Wang Hiroyuki Yamamoto Norio Nakata Source Type: research

Facilitation of ultrasonic microvesicles on homing and molecular mechanism of bone marrow mesenchymal stem cells in cerebral infarction patients.
CONCLUSIONS: Ultrasound microvesicle facilitated homing of BMSCs in cerebral infarction, and improved infarction disease via up-regulating VEGF expression, inhibiting NF-κB expression, and modulating apoptosis. PMID: 28975970 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Recent strategies on targeted delivery of thrombolytics
Publication date: Available online 4 February 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ting Huang, Ni Li, Jianqing GaoAbstractThrombus formed in blood vessel is a progressive process, which would lead to life-threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the recognition of thrombus is usually in the late stage where blood vessels are largely blocked. So acute thrombotic diseases have a narrow therapeutic window, and remain leading causes of morbidity and mortality, whereas current thrombolysis therapy has limited therapeutic effects and bleeding complications. Thromb...
Source: Asian Journal of Pharmaceutical Sciences - February 4, 2019 Category: Drugs & Pharmacology Source Type: research

Ultrasound-Induced Destruction of Nitric Oxide –Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury
Conclusion: Based on these data, UTMD affects the vascular endothelium by activating eNOS, and NO exerts a protective effect against IRI.
Source: Frontiers in Pharmacology - January 4, 2022 Category: Drugs & Pharmacology Source Type: research