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Sonothrombolysis.
Authors: Meairs S Abstract Ultrasound (US) applied as an adjunct to thrombolytic therapy improves the recanalization of occluded vessels, and microbubbles can amplify this effect. New data suggests that the combination of US and microbubbles without tissue plasminogen activator may achieve recanalization with a lower risk of hemorrhage. Further possibilities include specific targeting of thrombus with immunobubbles as well as local drug delivery with US-sensitive liposomes. Clinical studies support the use of US for ischemic stroke therapy, and the first trials of enhancing sonothrombolysis with microbubbles have b...
Source: Frontiers of Neurology and Neuroscience - December 2, 2015 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Microvascular decompression for elderly patients with trigeminal neuralgia
Publication date: Available online 2 March 2016 Source:Journal of Clinical Neuroscience Author(s): Kevin Phan, Prashanth J. Rao, Mark Dexter Microvascular decompression (MVD) has been demonstrated to be an excellent surgical treatment approach in younger patients with trigeminal neuralgia (TN). However, it is not clear whether there are additional morbidity and mortality risks for MVD in the elderly population. We performed a systematic literature review using six electronic databases for studies that compared outcomes for MVD for TN in elderly (cut-off ⩾60, 65, 70years) versus younger populations. Outcomes examined...
Source: Journal of Clinical Neuroscience - March 2, 2016 Category: Neuroscience Source Type: research

Increased risk for complications following diagnostic cerebral angiography in older patients: Trends from the Nationwide Inpatient Sample (1999–2009)
Publication date: Available online 16 July 2016 Source:Journal of Clinical Neuroscience Author(s): Omar Choudhri, Matthew Schoen, Aditya Mantha, Abdullah Feroze, Rohaid Ali, Michael T. Lawton, Huy M. Do The full utility of diagnostic cerebral angiography, an invasive cerebrovascular imaging technique, is currently debated. Our goal was to determine trends in diagnostic cerebral angiography utilization and associated complications from 1999 through 2009. The National Inpatient Sample (NIS) was used to identify patients who received primary cerebral angiography from 1999–2009 in the United States. We observed tren...
Source: Journal of Clinical Neuroscience - July 16, 2016 Category: Neuroscience Source Type: research

Bilateral cerebral embolism as a characteristic feature of patients with Trousseau syndrome
This study suggests that bilateral infarctions presenting microembolisms are important features of cerebral embolism attributed to Trousseau syndrome.
Source: Journal of Clinical Neuroscience - June 29, 2017 Category: Neuroscience Source Type: research

Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal
AbstractPurpose of ReviewAn 80-year-old man presents with an acute right hemiparesis and National Institutes of Health Stroke Scale (NIHSS) of 25, 14  h after taking dabigatran. Activated partial thromboplastin time (aPTT) is 42.8 s. Arteriogram demonstrates left internal carotid artery thrombosis. What is the appropriate management of this patient with acute ischemic stroke while on a NOAC?Recent FindingsIdarucizumab is a reversal agent approved for dabigatran, and two more reversal agents, andexanet alfa and aripazine, are currently in development for NOACs.SummaryIn this article, we review currently available NOACs, t...
Source: Current Neurology and Neuroscience Reports - July 22, 2017 Category: Neuroscience Source Type: research

Postoperative 30-day outcomes after craniotomy for supratentorial AVM resection in children
ConclusionIn the NSQIP-P dataset, the incidence of perioperative complications and suboptimal outcomes among patients undergoing AVM resection were low.
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yousheng Wu, Dan Lu, Anding XuAbstractThrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are controversially suggested to either increase or decrease the odds of better primary outcomes compared to treatment without statins after thrombolysis in patients or animals; statins are ...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Neurologic Manifestations of the Antiphospholipid Syndrome — an Update
AbstractPurpose of ReviewIn recent years, the spectrum of neurological manifestations of antiphospholipid syndrome (APS) has been growing. We provide a critical review of the literature with special emphasis on presentation, proposed mechanisms of disease, and treatment of neurological involvement in APS.Recent FindingsAlthough stroke is the most common cause of neurological manifestations in patients with APS, other neurological disorders have been increasingly associated with the disease, including cognitive dysfunction, headache, and epilepsy. Direct oral anticoagulants have failed to show non-inferiority compared to vi...
Source: Current Neurology and Neuroscience Reports - June 14, 2021 Category: Neuroscience Source Type: research

Artery and venous sinus occlusion image score (AVOIS): A novel method to evaluate occlusive cerebral arteries and venous diseases
CONCLUSION: The AVOIS can be used to evaluate the treatment of patients with acute stroke caused by cerebral venous sinus thrombosis and anterior circulation large vessel occlusion. It is a reliable and convenient method that may help prompt prognosis and guide the treatment of individual patients.PMID:34145753 | DOI:10.1111/cns.13689
Source: CNS Neuroscience and Therapeutics - June 19, 2021 Category: Neuroscience Authors: Zhimin Wu Qinglin Feng Mengqi Liu Jie Li Xiaochuan Sun Quanhong Shi Yan Zhan Wei Dan Bocheng Yang Dinghao Zheng Yulong Xia Yanfeng Xie Li Jiang Source Type: research

Risk factors of impaired employability after cerebral venous thrombosis
CONCLUSIONS: Impaired employability after CVT was associated with motor deficits, aphasia, mental status disorders, and NIHSS score at admission. Even if they recover from CVT without physical disability, patients with a good functional prognosis have a higher risk of employment failure due to their higher rates of aphasia and CVT recurrence.PMID:36601664 | DOI:10.1111/cns.14083
Source: CNS Neuroscience and Therapeutics - January 5, 2023 Category: Neuroscience Authors: Lu Liu Huimin Jiang Huimin Wei Yifan Zhou Yan Wu Kaiyuan Zhang Jiangang Duan Ran Meng Chen Zhou Xunming Ji Source Type: research

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