Stroke RSS Page 17

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Specialty: Hematology
Condition: Thrombosis

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Total 1625 results found since Jan 2013.

Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke
CONCLUSION: This study identified the spatiotemporal profile of NET formation in a mouse model of cerebral I/R injury in ischemic stroke. NETs, potentially in combination with VWF, might be attractive targets for the development of novel therapeutic strategies in ischemic stroke treatment.PMID:36852112 | PMC:PMC9958086 | DOI:10.1016/j.rpth.2022.100028
Source: Thrombosis and Haemostasis - February 28, 2023 Category: Hematology Authors: Maaike De Wilde Linda Desender Claudia Tersteeg Karen Vanhoorelbeke Simon F De Meyer Source Type: research

Protocol for a Systematic Review and Individual Participant Data Meta-Analysis of Randomized Trials of Screening for Atrial Fibrillation to Prevent Stroke
Thromb Haemost. 2023 Mar;123(3):366-376. doi: 10.1055/s-0042-1760257. Epub 2023 Mar 2.ABSTRACTINTRODUCTION: Atrial fibrillation (AF) is a common cause of stroke. Timely diagnosis of AF and treatment with oral anticoagulation (OAC) can prevent up to two-thirds of AF-related strokes. Ambulatory electrocardiographic (ECG) monitoring can identify undiagnosed AF in at-risk individuals, but the impact of population-based ECG screening on stroke is uncertain, as ongoing and published randomized controlled trials (RCTs) have generally been underpowered for stroke.METHODS AND ANALYSIS: The AF-SCREEN Collaboration, with support from...
Source: Thrombosis and Haemostasis - March 2, 2023 Category: Hematology Authors: AF SCREEN and AFFECT-EU Collaborators Source Type: research

The interaction effect of transfusion history and previous stroke history on the risk of venous thromboembolism in stroke patients: a prospective cohort study
Blood transfusion and previous stroke history are two independent risk factors of venous thromboembolism (VTE) in stroke patients. Whether the potential interaction of transfusion history and previous stroke h...
Source: Thrombosis Journal - April 17, 2023 Category: Hematology Authors: Changqing Sun, Rongrong Wang, Lianke Wang, Panpan Wang, Ying Qin, Qianyu Zhou, Yuanli Guo, Mingyang Zhao, Wenqian He, Bo Hu, Zihui Yao, Peijia Zhang, Tiantian Wu, Yu Wang and Qiang Zhang Tags: Research Source Type: research

The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases
Elderly people without atrial fibrillation (AF) still have a high incidence of cardioembolic stroke, suggesting that thrombus formation within the left atrial appendage (LAA) may also occur in an AF-independent manner. In the present study, we explored the potential mechanisms for aging-induced LAA thrombus formation and stroke in mice. We monitored stroke events in 180 aging male mice (14 –24 months) and assessed left atrium (LA) remodeling by echocardiography at different ages. Mice that had stroke were implanted with telemeters to confirm AF.
Source: Thrombosis Research - April 25, 2023 Category: Hematology Authors: Ruopeng Tan, Mengyang Yuan, Lin Wang, Jingjie Liu, Guinan Jiang, Jiawei Liao, Yun-Long Xia, Xiaomeng Yin, Yang Liu Source Type: research

Stroke with large vessel occlusion in the posterior circulation: IV thrombolysis plus thrombectomy versus IV thrombolysis alone
AbstractEfficacy and safety of mechanical thrombectomy (MT) for stroke with posterior circulation large vessel occlusion (LVO) is still under debate. We aimed to compare the outcomes of stroke patients with posterior circulation LVO treated with intravenous thrombolysis (IVT) (< 4.5 h after symptom onset) plus MT < 6 h after symptom onset with those treated with IVT alone (< 4.5 h after symptom onset). Patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) and in the Italian centers included in the SITS-ISTR were analysed. We identified 409 IRETAS patients treate...
Source: Journal of Thrombosis and Thrombolysis - August 19, 2023 Category: Hematology Source Type: research

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke
We hypothesized that leukocytes have 2 opposing effects on patients with ischemic stroke treated with recombinant tissue plasminogen activator (rtPA). Patients with ischemic stroke treated with rtPA were divided into 2 groups using the peripheral leukocyte count: high leukocyte group (HLG) and low leukocyte group (LLG) and were evaluated with the National Institutes of Health stroke scale (NIHSS) during the first 24 hours. We defined significant improvement (SI) as NIHSS improving by more than 50% from the baseline, and deterioration following improvement (DFI) as the achievement of SI within 24 hours but its subsequent lo...
Source: Clinical and Applied Thrombosis/Hemostasis - December 12, 2013 Category: Hematology Authors: Nomura, E., Naka, H., Wakabayashi, S., Kajikawa, H., Matsumoto, M. Tags: Original Articles Source Type: research

Factor VIII in the Setting of Acute Ischemic Stroke Among Patients With Suspected Hypercoagulable State
Conclusions: High factor VIII level was found in the majority of tested patients with AIS. Several baseline differences were found between patients with normal and high factor VIII levels, but no differences were identified in outcome.
Source: Clinical and Applied Thrombosis/Hemostasis - January 28, 2014 Category: Hematology Authors: Chang, T. R., Albright, K. C., Boehme, A. K., Dorsey, A., Sartor, E. A., Kruse-Jarres, R., Leissinger, C., Martin-Schild, S. Tags: Original Articles Source Type: research

Patient's values and preferences for stroke prevention in atrial fibrillation: balancing stroke and bleeding risk with oral anticoagulation.
PMID: 24477628 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 30, 2014 Category: Hematology Authors: Lane DA, Lip GY Tags: Thromb Haemost Source Type: research

Gaps in translation from trials to practice: Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation.
The objectives of this review are to 1) identify gaps in our current knowledge regarding use of these single target anticoagulant drugs; 2) outline the potential implications of these gaps for clinical practice, and thereby, 3) highlight areas of research to further optimise their use for stroke prevention in AF. PMID: 24573511 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 27, 2014 Category: Hematology Authors: Hylek EM, Ko D, Cove CL Tags: Thromb Haemost Source Type: research

Improving Prediction of Recanalization in Acute Large Vessel Occlusive Stroke
ConclusionsAcute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. Presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS and ASPECTS and normal vigilance facilitate recanalization. Integration in treatment algorithms could influence recanalization strategies in individual patients.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - March 1, 2014 Category: Hematology Authors: Peter Vanacker, Dimitris Lambrou, Ashraf Eskandari, Philippe Maeder, Reto Meuli, George Ntaios, Patrik Michel Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Elevated levels of D-dimers increase the risk of ischaemic and haemorrhagic stroke. Findings from the EPICOR Study.
In conclusion, our data provide clear evidence that elevated levels of D-dimers are potential risk factors not only for ischaemic but also for haemorrhagic strokes. PMID: 25030937 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 17, 2014 Category: Hematology Authors: Di Castelnuovo A, Agnoli C, de Curtis A, Giurdanella MC, Sieri S, Mattiello A, Matullo G, Panico S, Sacerdote C, Tumino R, Vineis P, de Gaetano G, Donati MB, Iacoviello L Tags: Thromb Haemost Source Type: research

Efficacy and safety of thrombolysis for stroke of unknown onset time: a meta-analysis
Abstract Current stroke treatment guidelines exclude unknown onset stroke (UOS) patients from thrombolytic therapy even though several studies have reported significant treatment efficacy and safety. We performed a meta-analysis of relevant studies retrieved by systematic searches of the PubMed, Embase, and Cochrane databases up to December 31, 2013. Dichotomized modified Rankin Scale (mRS) scores 0–1 at 90 days, mRS 0–2 at 90 days, overall mortality, and symptomatic intracranial hemorrhage (sICH) incidence were collected as primary outcome measures. Fixed effects meta-analytical models were used, and betwe...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Risk of ischaemic stroke associated with non-steroidal antiinflammatory drugs and paracetamol: a population-based case-control study.
CONCLUSIONS: Diclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk. This article is protected by copyright. All rights reserved. PMID: 25611553 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: García-Poza P, de Abajo FJ, Gil MJ, Chacón A, Bryant V, García-Rodríguez LA Tags: J Thromb Haemost Source Type: research

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