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Specialty: Cardiovascular & Thoracic Surgery
Condition: Thrombosis

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Total 372 results found since Jan 2013.

Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures
ConclusionThrombotic related dysfunction post‐TMVR occurred in 15% (2/13) of patients and one patient had abnormal leaflet thickening that may have been thrombus related. Dual‐antiplatelet therapy was used in all 3 cases suggesting the possible need for oral anticoagulation postmitral valve‐in‐valve therapy. © 2017 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - February 9, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Marvin H. Eng, Adam Greenbaum, Dee Dee Wang, Janet Wyman, DNP, Heider Arjomand, Pradeep Yadav, Hassan Nemeh, Gaetano Paone, Mayra Guerrero, William O'Neill Tags: Valvular and Structural Heart Diseases Source Type: research

Straddling embolus across patent foramen ovale in a case of pulmonary embolism
We present a case of a 37-year-old male who had deep venous thrombosis with acute massive pulmonary embolism and stroke. Transesophageal echocardiography revealed large straddling thrombus in patent foramen ovale along with branch pulmonary artery embolus. Patent foramen ovale was closed and pulmonary artery embolus was removed surgically. We conclude that surgery is the best mode of management in the presence of patent foramen ovale.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - March 6, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Comparison of antithrombotic agents during urgent percutaneous coronary intervention following thrombolytic therapy: A retrospective cohort study
ConclusionIn STEMI patients undergoing PCI within 24 hr after thrombolytic therapy, bivalirudin was associated with a strong trend toward reduced bleeding complications as compared to heparin alone or heparin plus GPI.The optimal antithrombotic regiment for urgent PCI following thrombolytic therapy is currently unknown. Our study demonstrated that use of bivalirudin during PCI following thrombolytic therapy is associated with a trend toward reduced bleeding complications compared to heparin alone or heparin plus GPI. Large randomized trials of adjunctive anticoagulation during PCI in this complex post‐thrombolytic popula...
Source: Catheterization and Cardiovascular Interventions - April 18, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Jaya R. Mallidi, Peter Robinson, Paul F. Visintainer, Amir S. Lotfi, Scott Mulvey, Gregory R. Giugliano Tags: Coronary Artery Disease Source Type: research

30-day results from prospective multi-specialty evaluation of carotid artery stenting using the CGuard micronet-covered embolic prevention stent system in real world multicenter clinical practice: the IRON-GUARD study.
CONCLUSIONS: Multi-center multi-specialty use of the CGuard EPS in routine clinical practice was associated with no major peri-procedural neurologic complications and a total elimination of post-procedural neurologic complications by 30 days. PMID: 28485278 [PubMed - as supplied by publisher]
Source: EuroIntervention - May 10, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Emergency HeartWare Ventricular Assist Device (HVAD) exchange due to pump thrombosis using minimally invasive technique.
This report documents the very first LVAD pump exchange as well as the first one performed via a minimally invasive approach in Poland. PMID: 28515757 [PubMed - in process]
Source: Polish Journal of Cardio-Thoracic Surgery - May 19, 2017 Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research

Pulmonary hypertension and right heart failure due to severe hypernatremic dehydration.
CONCLUSION: A high index of suspicion is paramount to diagnose pulmonary hypertension and aggressive correction of the acidosis and hypoxia is needed. In the presence of severe right ventricular failure, ECMO can be used as a bridge to recovery while underlying metabolic derangements are being corrected. PMID: 28553778 [PubMed - in process]
Source: Perfusion - May 30, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Chiwane S, Ahmed TM, Bauerfeld CP, Chauhan M Tags: Perfusion Source Type: research

Left atrial appendage occlusion with the AMPLATZER Amulet device: periprocedural and early clinical/echocardiographic data from a global prospective observational study.
CONCLUSIONS: This large real-world prospective registry of catheter-based LAAO using the AMPLATZER Amulet device reports a high implant success rate and a low periprocedural complication rate in a population with a high risk of stroke and bleeding. Transoesophageal echo data confirm good closure rates during follow-up and low rates of device-associated thrombus. PMID: 28649053 [PubMed - as supplied by publisher]
Source: EuroIntervention - June 28, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Heparin: Effects upon the Glycocalyx and Endothelial Cells.
Authors: Spiess BD Abstract Unfractionated heparin (UFH) is the most widely used injectable medication in the United States. UFH is a poly-dispersed, relatively impure combination of many polysaccharides known as a glycosaminoglycan. It is used as the primary anticoagulant for heart surgery as well as for active treatment of deep venous thrombosis, vascular thrombosis, stroke, and many other potentially catastrophic clotting syndromes. Many perfusionists and cardiac team members know little of the biology of UFH other than its use for cardiopulmonary bypass. UFH is very similar to heparin sulfate, found on the surf...
Source: Journal of Extra-Corporeal Technology - October 7, 2017 Category: Cardiovascular & Thoracic Surgery Tags: J Extra Corpor Technol Source Type: research

Thromboembolism after WATCHMANTM in a clopidogrel non ‐responder: A case for concern?
Abstract Atrial fibrillation (AF) is associated with an increased risk of stroke and thromboembolism (TE). The WATCHMANTM left atrial appendage (LAA) closure device is indicated to reduce the risk of TE from the LAA in patients with non‐valvular AF. Here, we present a case of a patient with device‐related thrombus who suffered a TE event two months after WATCHMANTM LAA closure and two weeks after switching from aspirin plus warfarin to aspirin plus clopidogrel therapy. Laboratory investigation identified the patient to be hypercoagulable and to be a non‐responder to clopidogrel therapy. We discuss the potential role ...
Source: Catheterization and Cardiovascular Interventions - November 11, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Ganesh Venkataraman, Kevin P. Bliden, Udaya S. Tantry, Paul A. Gurbel Tags: VALVULAR AND STRUCTURAL HEART DISEASES Source Type: research

Dual antiplatelet therapy at discharge: Antiplatelet practice patterns after coronary artery bypass grafting, surgical anecdote is driving standard of care
Thrombosis and platelet aggregation are key pathogenic mechanisms in acute coronary syndromes (ACS). Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor has been demonstrated to reduce death from cardiovascular causes, nonfatal myocardial infarction, and stroke after ACS.1-3 These large randomized controlled trials studied heterogeneous populations of patients with ACS treated with medical therapy, percutaneous coronary intervention, or coronary bypass grafting (CABG). The data supporting DAPT after CABG are less robust and limited to observational studies, subgroup analyses, and smaller randomized studies ...
Source: The Journal of Thoracic and Cardiovascular Surgery - November 8, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mark Helmers, Pavan Atluri Tags: Editorial commentary Source Type: research

Evolution of Simplified Frozen Elephant Trunk Repair for Acute DeBakey Type I Dissection: Midterm Outcomes
Conclusions Simplified FET for treating acute DeBakey type I dissection has evolved and remained safe. It promotes aortic remodeling, and simplifies management of chronic aortic complications.
Source: The Annals of Thoracic Surgery - December 6, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Evolution of Simplified Frozen Elephant Trunk Repair for Acute DeBakey Type I Dissection: Midterm Outcomes.
CONCLUSIONS: Simplified FET for treating acute DeBakey type I dissection has evolved and remained safe. It promotes aortic remodeling, and simplifies management of chronic aortic complications. PMID: 29217087 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - December 4, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Roselli EE, Idrees JJ, Bakaeen FG, Tong MZ, Soltesz EG, Mick S, Johnston DR, Eagleton MJ, Menon V, Svensson LG Tags: Ann Thorac Surg Source Type: research

Complex coronary bifurcation treatment by a novel stenting technique: Bench test, fluid dynamic study and clinical outcomes
ConclusionsThe revascularization of complex large coronary bifurcation disease using the Nano‐crush technique appeared promising thanks to the favorable fluid dynamic profile, complete coverage of the SD ostium, and very small metal amount at the carina.
Source: Catheterization and Cardiovascular Interventions - January 25, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Dobrin Vassilev, Ramesh Daggubati, Thach Nguyen, Minh Tr í Nhân Nguyễn, Nicolas Foin Tags: CORONARY ARTERY DISEASE Source Type: research

Short-term dual antiplatelet therapy after interventional left atrial appendage closure with different devices.
CONCLUSIONS: Short-term DAPT for six weeks appears to be a viable alternative for patients after LAAC. Age ≥75 years and renal impairment increase major bleeding events threefold. PMID: 29400653 [PubMed - as supplied by publisher]
Source: EuroIntervention - February 7, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Don't change the guidelines yet, randomized data on surgical left atrial appendage closure is on the horizon
Atrial fibrillation (AF) remains the most common rhythm disorder of clinical significance1 and one of the leading causes of cardiogenic ischemic events.2 The most common anatomic source of thrombus in patients with AF is the left atrial appendage (LAA).3 Greater than 10% of patients undergoing cardiac surgery have been diagnosed with AF preoperatively,4 so surgeons have naturally had long-standing interest in LAA interventions that might reduce the risk of stroke. Unfortunately, the data currently available to support routine surgical LAA occlusion present a mixed picture, even to the most optimistic surgeon.
Source: The Journal of Thoracic and Cardiovascular Surgery - April 12, 2018 Category: Cardiovascular & Thoracic Surgery Authors: John J. Squiers, J. Michael DiMaio Tags: Editorial commentary Source Type: research