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Total 128 results found since Jan 2013.

Regarding "Automated Segmentation of Intracranial Thrombus on NCCT and CTA in Patients with Acute Ischemic Stroke Using a Coarse-to-Fine Deep Learning Model" letter
Source: American Journal of Neuroradiology - September 11, 2023 Category: Radiology Authors: Tortora, M., Pacchiano, F. Tags: letter Source Type: research

What Are the Complications of Sickle Cell Trait?
Discussion Sickle cell disease (SCD) is a group of inherited blood disorders where there are abnormal hemoglobin molecules and the red blood cells take on a characteristic sickled shape instead of a rounded shape. Sickled hemoglobin provides an evolutionary advantage of giving the individual increased protection against severe and cerebral malaria. The sickled shape doesn’t move through the vascular system as well and therefore is more likely to aggregate in small vessels causing an increased risk of vaso-occlusive disease, acute chest syndrome, splenic sequestration, and priapism. There is also an increased risk of ...
Source: PediatricEducation.org - September 4, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

HIT-Heparin Induced Thrombocytopenia Simulation Case
Discussion: The simulation improved awareness of the symptoms of HIT and contraindications of immediate platelet and/or heparin initiation upon vessel occlusion and thrombocytopenia discovery.Topics: Heparin-induced thrombocytopenia, pain control, resuscitation efforts, coagulation disorders, history taking, undifferentiated patient, arterial occlusion, hematology, emergency medicine simulation.PMID:37465544 | PMC:PMC10332759 | DOI:10.21980/J89Q0M
Source: Pain Physician - July 19, 2023 Category: Anesthesiology Authors: Shaza Aouthmany Alyssa Siano De Ante' Russ Mark Bustillo Source Type: research

Prediction of short-term atrial fibrillation risk using primary care electronic health records
Conclusions FIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Nadarajah, R., Wu, J., Hogg, D., Raveendra, K., Nakao, Y. M., Nakao, K., Arbel, R., Haim, M., Zahger, D., Parry, J., Bates, C., Cowan, C., Gale, C. P. Tags: Open access, Editor's choice Arrhythmias and sudden death Source Type: research

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites
Conclusions Six metabolites as potential predictors for distinguishing between cerebral thrombi of CE and LAA origin were identified. The results are useful for understanding the pathogenesis and for secondary stroke prevention.
Source: Journal of NeuroInterventional Surgery - June 16, 2023 Category: Neurosurgery Authors: Li, W., Bai, X., Hao, J., Xu, X., Lin, F., Jiang, Q., Ding, C., Dai, G., Peng, F., Zhang, M., Feng, Y., Wang, J., Chen, X., Xue, T., Guo, X., Fu, Z., Chen, W.-h., Zhang, L., Wang, C., Jiao, L. Tags: Basic science Source Type: research

Automated Segmentation of Intracranial Thrombus on NCCT and CTA in Patients with Acute Ischemic Stroke Using a Coarse-to-Fine Deep Learning Model ADULT BRAIN
CONCLUSIONS: The proposed deep learning method can reliably detect and measure thrombi on NCCT and CTA in patients with acute ischemic stroke.
Source: American Journal of Neuroradiology - June 8, 2023 Category: Radiology Authors: Zhu, K., Bala, F., Zhang, J., Benali, F., Cimflova, P., Kim, B. J., McDonough, R., Singh, N., Hill, M. D., Goyal, M., Demchuk, A., Menon, B. K., Qiu, W. Tags: ADULT BRAIN Source Type: research

Milvexian Granted U.S. FDA Fast Track Designation for All Three Indications Under Evaluation in Phase 3 Librexia Program: Ischemic Stroke, Acute Coronary Syndrome and Atrial Fibrillation
RARITAN, NJ, May 25, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that all three prospective indications for milvexian, an investigational oral factor XIa (FXIa) inhibitor (being developed in collaboration with Bristol Myers Squibb), have now been granted Fast Track Designation by the U.S. Food and Drug Administration (FDA). The designations cover all three indication-seeking studies within the Phase 3 Librexia development program (Librexia STROKE, Librexia ACS and Librexia AF), which are all dosing patients. The Librexia program is unrivaled as the most comprehensive FXIa clinical...
Source: Johnson and Johnson - May 25, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Identifying ex vivo acute ischemic stroke thrombus composition using electrochemical impedance spectroscopy
CONCLUSION: Combination of EIS and machine learning can reliably predict the RBC composition of retrieved ex vivo AIS thrombi and then classify them into groups according to their RBC composition with good sensitivity and specificity.PMID:37192738 | DOI:10.1177/15910199231175377
Source: Interventional Neuroradiology - May 16, 2023 Category: Radiology Authors: Jean Darcourt Waleed Brinjikji Olivier Fran çois Alice Giraud Collin R Johnson Smita Patil Senna Staessens Ramanathan Kadirvel Mahmoud H Mohammaden Leonardo Pisani Gabriel Martins Rodrigues Nicole M Cancelliere Vitor Mendes Pereira Franz Bozsak Karen Doy Source Type: research

Impedance-based sensors discriminate among different types of blood thrombi with very high specificity and sensitivity
Conclusions Combining EIS measurements with machine learning provides a highly effective approach for discriminating among different thrombus types and liquid blood. These findings raise the possibility of developing a probe-like device (eg, a neurovascular guidewire) integrating an impedance-based sensor. This sensor, placed in the distal part of the smart device, would allow the characterization of the probed thrombus on contact. The information could help physicians identify optimal thrombectomy strategies to improve outcomes for stroke patients.
Source: Journal of NeuroInterventional Surgery - May 16, 2023 Category: Neurosurgery Authors: Messina, P., Garcia, C., Rambeau, J., Darcourt, J., Balland, R., Carreel, B., Cottance, M., Gusarova, E., Lafaurie-Janvore, J., Lebedev, G., Bozsak, F., Barakat, A. I., Payrastre, B., Cognard, C. Tags: Open access, Ischemic stroke Source Type: research

Identification, characterization, and engineering of glycosylation in thrombolyticsa
Biotechnol Adv. 2023 May 12:108174. doi: 10.1016/j.biotechadv.2023.108174. Online ahead of print.ABSTRACTCardiovascular diseases, such as myocardial infarction, ischemic stroke, and pulmonary embolism, are the most common causes of disability and death worldwide. Blood clot hydrolysis by thrombolytic enzymes and thrombectomy are key clinical interventions. The most widely used thrombolytic enzyme is alteplase, which has been used in clinical practice since 1986. Another clinically used thrombolytic protein is tenecteplase, which has modified epitopes and engineered glycosylation sites, suggesting that carbohydrate modifica...
Source: Biotechnology Advances - May 14, 2023 Category: Biotechnology Authors: Martin Toul Veronika Slonkova Jan Mican Adam Urminsky Maria Tomkova Erik Sedlak David Bednar Jiri Damborsky Lenka Hernychova Zbynek Prokop Source Type: research

CT-based thrombus radiomics nomogram for predicting secondary embolization during mechanical thrombectomy for large vessel occlusion
ConclusionThis nomogram could be used to optimize the surgical MT procedure for LVO based on the risk of developing SE.
Source: Frontiers in Neurology - May 12, 2023 Category: Neurology Source Type: research