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Specialty: Allergy & Immunology
Condition: Stroke
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Total 746 results found since Jan 2013.
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest mortality and disability rate of cardiovascular disease. Current studies have shown that nerve cells die of ischemia several hours after ischemic stroke, which activates the innate immune response in the brain, promotes the production of neurotoxic substances such as inflammatory cytokines, chemokines, reactive oxygen species and − nitrogen oxide, and mediates the destruction of blood-brain barrier and the occurrence of a series of inflammatory cascade reactions. Meanwhile, the expression of adhesion molecules in cerebral vascular e...
Source: Frontiers in Immunology - October 7, 2022 Category: Allergy & Immunology Source Type: research
Uveitis increases the risk of stroke among patients with ankylosing spondylitis: A nationwide population-based longitudinal study
Ankylosing spondylitis (AS) is known to increase the risk of stroke. Among patients with AS, uveitis is the most common extra-articular manifestation. However, no previous investigations have discussed the association between uveitis and the risk for developing stroke in patients with AS. This retrospective cohort study aimed to explore the relationship between uveitis and the incidence of stroke in patients with AS by obtaining medical records from January 1, 2000, to December 31, 2015, from the National Health Insurance Research Database, according to the International Classification of Diseases, 9th Revision, Clinical M...
Source: Frontiers in Immunology - October 6, 2022 Category: Allergy & Immunology Source Type: research
The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
ConclusionsWMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool.
Source: Frontiers in Immunology - October 3, 2022 Category: Allergy & Immunology Source Type: research
Exploring the risk factors for ischemic cerebrovascular disease in systemic lupus erythematosus: A single-center case-control study
ConclusionCutaneous vasculitis and antiphospholipid antibodies (aPLs) are associated with an increased risk of ICVD, while HCQ therapy may provide protection against ICVD in SLE. The ICVD in younger lupus patients is associated with complement-mediated inflammation and poorer outcome, and require immunosuppressive therapy, whereas the ICVD in elderly patients are characterized by moderate ICAS and carotid atherosclerotic plaques.
Source: Frontiers in Immunology - September 27, 2022 Category: Allergy & Immunology Source Type: research
The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective
ConclusionsCRP polymorphisms, SA based on CRP genotype, and peripheral monocytes are associated with the risk of early-onset PSD, suggesting peripheral immuno-inflammatory activities elicited by stroke in its aetiology.
Source: Frontiers in Immunology - September 26, 2022 Category: Allergy & Immunology Source Type: research
Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients
ConclusionsWe found the PLR to be a variable that potentially predicts the risks of poor outcome and death in patients with acute ischemic stroke 24 h after rtPA; however, it cannot make the same prediction on admission.
Source: Frontiers in Immunology - September 26, 2022 Category: Allergy & Immunology Source Type: research
Association Between Neutrophil-to-Lymphocyte Ratio/Lymphocyte-to-Monocyte Ratio and In-Hospital Clinical Outcomes in Ischemic Stroke Treated with Intravenous Thrombolysis
Source: Journal of Inflammation Research - September 23, 2022 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Systemic immune responses after ischemic stroke: From the center to the periphery
Ischemic stroke is a leading cause of disability and death. It imposes a heavy economic burden on individuals, families and society. The mortality rate of ischemic stroke has decreased with the help of thrombolytic drug therapy and intravascular intervention. However, the nerve damage caused by ischemia-reperfusion is long-lasting and followed by multiple organ dysfunction. In this process, the immune responses manifested by systemic inflammatory responses play an important role. It begins with neuroinflammation following ischemic stroke. The large number of inflammatory cells released after activation of immune cells in t...
Source: Frontiers in Immunology - September 20, 2022 Category: Allergy & Immunology Source Type: research
Chrysophanol facilitates long-term neurological recovery through limiting microglia-mediated neuroinflammation after ischemic stroke in mice
CONCLUSIONS: CHR ameliorated microenvironment for neural plasticity and exhibited neuroprotection via arresting microglia toward pro-inflammatory phenotype and downregulation of the expressions of pro-inflammatory cytokines, especially of IL-6. IL-6-STAT3 signaling might be CHR's therapeutic target for neuroinflammatory responses after stroke.PMID:36095949 | DOI:10.1016/j.intimp.2022.109220
Source: International Immunopharmacology - September 12, 2022 Category: Allergy & Immunology Authors: Xiaoxia Liu Xiangjian Zhang Junmin Chen Degang Song Cong Zhang Rong Chen Renhao Xu Wei Jiang Li Li Source Type: research
The Potential for Treg-Enhancing Therapies in Nervous System Pathologies
Clin Exp Immunol. 2022 Aug 30:uxac084. doi: 10.1093/cei/uxac084. Online ahead of print.ABSTRACTWhile inflammation may not be the cause of disease, it is well known that it contributes to disease pathogenesis across a multitude of peripheral and central nervous system disorders. Chronic and overactive inflammation due to an effector T cell-mediated aberrant immune response ultimately leads to tissue damage and neuronal cell death. To counteract peripheral and neuroinflammatory responses, research is being focused on regulatory T cell enhancement as a therapeutic target. Regulatory T cells are an immunosuppressive subpopulat...
Source: Clinical and Developmental Immunology - August 30, 2022 Category: Allergy & Immunology Authors: Katherine E Olson R L Mosley Howard E Gendelman Source Type: research
SCO-spondin-derived peptide NX210 rescues neurons from cerebral ischemia/reperfusion injury through modulating the Integrin- β1 mediated PI3K/Akt pathway
This study investigated whether NX210 had therapeutic effects and possible underlying mechanisms against cerebral ischemia/reperfusion (I/R). Therefore, primary embryonic rat cortical neurons and Sprague-Dawley (SD) rats that were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) and middle cerebral artery occlusion/reperfusion (MCAO/R) injuries, respectively, were treated with or without NX210. We found that NX210 reduced OGD/R-induced cell viability loss and cytotoxicity. NX210 decreased cerebral infarct volume and brain edema, ameliorated neurological dysfunction, attenuated oxidative stress damage, and dimi...
Source: International Immunopharmacology - August 5, 2022 Category: Allergy & Immunology Authors: Liyu Yang Jin Zhu Li Yang Yunhao Gan Di Hu Jing Zhao Yong Zhao Source Type: research
Intravenous Thrombolysis Combined with Arterial Thrombolysis (Bridging Therapy) Effectively Improves Vascular Recanalization Rate in Patients with Cerebral Infarction
CONCLUSION: Bridging therapy can improve the vascular recanalization rate among patients suffering from acute cerebral infarction, reduce the incidence of intracranial hemorrhage and reembolization, and improve the prognosis and neurological function of patients, which is worthy of clinical application.PMID:35928632 | PMC:PMC9345711 | DOI:10.1155/2022/8295212
Source: Journal of Immunology Research - August 5, 2022 Category: Allergy & Immunology Authors: Junting Huo Wei Li Yu Liu Source Type: research
