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Condition: Stroke
Drug: Prozac
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Total 193 results found since Jan 2013.
Fluoxetine potentiates phagocytosis and autophagy in microglia
In conclusion, fluoxetine induces autophagy and potentiates phagocytosis in microglia, which can be a novel molecular mechanism of the neuroinflammatory and neuroprotective effects of fluoxetine.
Source: Frontiers in Pharmacology - November 24, 2021 Category: Drugs & Pharmacology Source Type: research
Use of antidepressants in unipolar depression in the elderly
CONCLUSIONS: Unipolar major depressive episodes in the elderly are frequent and their medicinal treatment has specific features. Knowing the specificities of antidepressant use in the elderly allows to optimize its efficiency and to limit the risk of inappropriate prescription leading to harmful adverse effects.PMID:35153054 | DOI:10.1016/j.encep.2021.11.006
Source: L Encephale - February 14, 2022 Category: Psychiatry Authors: A Pericaud C Straczek F Montastruc M Leboyer A Yrondi C Arbus Source Type: research
E-194 A randomized double-blind placebo-controlled trial of prophylactic antidepressant medication for the prevention of depression post aneurysmal subarachnoid hemorrhage
ConclusionsThe initial results of this ongoing study illustrate the feasibility and challenges of mental health screening and prophylactic randomized treatment in the acute care setting for post-SAH patients. Recruitment has been a challenge in this patient population. Here we describe the trends we see in outcomes at 12-months compared to baseline. These trends suggest that despite clinical improvement there may be an increase in depression and anxiety development one-year post-aSAH.Disclosures J. Keen: None. D. Lim: None. K. Prijoles: None. H. Haughn: None. C. Galang: None. A. Duboysky: None. E. Byun: None. K. Carroll: N...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Keen, J., Lim, D., Prijoles, K., Haughn, H., Galang, C., Duboysky, A., Byun, E., Carroll, K., Kelly, C., Federico, E., Gonzalez, A., Levitt, M., Kim, L. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
AbstractAntidepressants have been reported to enhance stroke recovery independent of the presence of depressive symptoms. They have recently been proposed to exert their mood-stabilizing actions by inhibition of acid sphingomyelinase (ASM), which catalyzes the hydrolysis of sphingomyelin to ceramide. Their restorative action post-ischemia/reperfusion (I/R) still had to be defined. Mice subjected to middle cerebral artery occlusion or cerebral microvascular endothelial cells exposed to oxygen –glucose deprivation were treated with vehicle or with the chemically and pharmacologically distinct antidepressants amitriptyline,...
Source: Basic Research in Cardiology - August 29, 2022 Category: Cardiology Source Type: research
Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders
CONCLUSIONS: TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.PMID:36089851 | DOI:10.1080/13880209.2022.2116460
Source: Pharmaceutical Biology - September 12, 2022 Category: Drugs & Pharmacology Authors: Xiaoping Zhang Zeng Li Chuanpu Shen Jinzhi He Longfei Wang Lei Di Bin Rui Ning Li Zhicheng Liu Source Type: research
Cognitive Impairment After Stroke and Treatment With Fluoxetine: A Planned Analysis of the AFFINITY Randomized Controlled Trial
Am J Geriatr Psychiatry. 2022 Aug 20:S1064-7481(22)00494-8. doi: 10.1016/j.jagp.2022.08.002. Online ahead of print.NO ABSTRACTPMID:36115731 | DOI:10.1016/j.jagp.2022.08.002
Source: The American Journal of Geriatric Psychiatry - September 17, 2022 Category: Psychiatry Authors: Osvaldo P Almeida Graeme J Hankey Andrew Ford Christopher Etherton-Beer Leon Flicker Maree L Hackett AFFINITY Trial Collaboration Source Type: research
