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High prevalence of abdominal aortic aneurysm in older men with cerebrovascular disease: Evaluation of a local screening program
This report evaluates the results of a decade's operation of a local screening program for AAA in this selected neurologic population.MethodsMen aged ≥60 years and admitted to the neurology ward of a community-based hospital in the Netherlands from 2006 to 2017 with a diagnosis of TIA or stroke were selected for screening. The diameter of the abdominal aorta was assessed by abdominal ultrasonography. Patients with detected AAA were referred for evaluation by a vascular surgeon.ResultsAAA was detected in 72 of 1,035 screened patients (6.9%). AAAs with a diameter of 3.0–3.9 cm accounted for 61.1% of the total aneurysms f...
Source: Frontiers in Neurology - April 11, 2023 Category: Neurology Source Type: research

Hypertensive response to exercise in adult patients with repaired aortic coarctation
Conclusions A hypertensive response to exercise was present in nearly half of the patients in this large, prospective cohort of adults with repaired CoA. Risk factors for increased peak exercise SBP were male sex, absence of a bicuspid aortic valve and elevated resting SBP. Increased peak exercise SBP independently predicted hypertension at follow-up. These results support close follow-up of patients with a hypertensive response to exercise to ensure timely diagnosis and treatment of future hypertension.
Source: Heart - June 24, 2022 Category: Cardiology Authors: Meijs, T. A., Muller, S. A., Minderhoud, S. C. S., de Winter, R. J., Mulder, B. J. M., van Melle, J. P., Hoendermis, E. S., van Dijk, A. P. J., Zuithoff, N. P. A., Krings, G. J., Doevendans, P. A., Spiering, W., Witsenburg, M., Roos-Hesselink, J. W., van Tags: Congenital heart disease Source Type: research

Total endovascular repair of the aortic arch: initial experience in the Netherlands
ConclusionsTotal endovascular aortic arch repair using the Relay Branch device is technically feasible and effective in excluding aortic arch pathology. The observed stroke rate in the initial experience, however, was considerable. Although appealing, this new lesser-invasive technique should be carefully introduced, and its progress thoroughly evaluated.
Source: The Annals of Thoracic Surgery - October 5, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Total endovascular repair of the aortic arch: initial experience in the Netherlands.
CONCLUSIONS: Total endovascular aortic arch repair using the Relay Branch device is technically feasible and effective in excluding aortic arch pathology. The observed stroke rate in the initial experience, however, was considerable. Although appealing, this new lesser-invasive technique should be carefully introduced, and its progress thoroughly evaluated. PMID: 31593657 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - October 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: van der Weijde E, Heijmen RH, van Schaik PM, Hazenberg CEVB, van Herwaarden JA Tags: Ann Thorac Surg Source Type: research

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation
Conclusion: These results suggest intelectin-1 promotes angiogenesis, inhibits oxidative stress and reduces apoptosis by stimulating the Akt-eNOS signaling pathway in response to ischemia in vitro. Introduction Stroke is a main reason of human neurological disability, ischemic stroke (IS) accounts for almost 80–90% of all strokes. IS occurs after a cerebral blood flow disruption, leading to cellular death and tissue damage by restricting glucose and oxygen supplies (1). Ischemic vascular diseases cause substantial vascular valve and vascular endothelial cell injuries, eventually damaging the surrounding tis...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Effects of Normothermic Machine Perfusion Conditions on Mesenchymal Stromal Cells
In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Mitro-aortic pathology: a  point of view for a fully transcatheter staged approach.
Mitro-aortic pathology: a point of view for a fully transcatheter staged approach. Neth Heart J. 2017 Aug 02;: Authors: D'Ancona G, Paranskaya L, Öner A, Kische S, Ince H Abstract Severe aortic valve stenosis (AVS) and mitral valve regurgitation (MVR) often coexist. Although a fully percutaneous treatment for the two conditions, by means of transcatheter aortic valve implantation (TAVI) followed by MitraClip, can be appealing in selected high-risk candidates, critical and strategical reasoning should be applied. In a 3-year period we have developed a single-centre experience of 14 patients who ...
Source: Netherlands Heart Journal - August 2, 2017 Category: Cardiology Authors: D'Ancona G, Paranskaya L, Öner A, Kische S, Ince H Tags: Neth Heart J Source Type: research