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A self-assembled polyjuglanin nanoparticle loaded with doxorubicin and anti-Kras siRNA for attenuating multidrug resistance in human lung cancer.
Abstract Lung cancer is a leading cause of cancer-associated mortality worldwide, which has a low survival rate. Multidrug resistance (MDR) is a major obstacle that hinders the treatment of lung cancer. Doxorubicin (DOX) is an anthracycline glycoside antibiotic, having a broad spectrum of anticancer activity against various solid tumors. Juglanin is a natural production, mainly extracted from green walnut husks of Juglans mandshurica, exhibiting various bioactivities. Here, we demonstrated that the combination of drug, gene and nanoparticle overcame MDR, inhibiting lung cancer progression. A novel nanoparticular p...
Source: Biochemical and Biophysical Research communications - October 31, 2017 Category: Biochemistry Authors: Wen ZM, Jie J, Zhang Y, Liu H, Peng LP Tags: Biochem Biophys Res Commun Source Type: research

Reversing of multidrug resistance breast cancer by co-delivery of P-gp siRNA and doxorubicin via folic acid-modified core-shell nanomicelles
Publication date: 1 February 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 138 Author(s): Yang Wu, Yu Zhang, Wei Zhang, Chunlong Sun, Jianzhong Wu, Jinhai Tang Multidrug resistance (MDR) remains one of major limitation for the successful treatment of many cancers including breast cancer. Co-delivery of chemotherapeutic drugs and small interfering RNA (siRNA) has been developed because of its ability to generate synergistic anticancer effects via different mechanisms of action, to reverse MDR and increase the efficacy of chemotherapeutic drugs in cancer therapy. Herein, we employed a kind of efficient m...
Source: Colloids and Surfaces B: Biointerfaces - December 2, 2015 Category: Biochemistry Source Type: research

A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance
Publication date: 1 November 2017 Source:Colloids and Surfaces B: Biointerfaces, Volume 159 Author(s): Yuqiong Xia, Xiaofei Wang, He Cheng, Mei Fang, Pengbo Ning, Yulu Zhou, Wei Chen, Hongjin Song Multidrug resistance (MDR) is one of the important factors that impede effective chemotherapy against cancer. Codelivery of MDR1 siRNA (silencing ABCB1 gene) and anticancer drug can greatly inhibit tumor proliferation. Here in this work, we synthesized poly(diallyldimethylammonium chloride) (PDADMAC) coated liposome formula as siMDR1 carrier (AL-PDAD-RNA) and applied it to reverse doxorubicin resistance of OVCAR8/ADR cells. The ...
Source: Colloids and Surfaces B: Biointerfaces - August 19, 2017 Category: Biochemistry Source Type: research

Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Xiao-Lei Shi, Yuan Li, Lu-Ming Zhao, Lin-Wang Su, Gang DingAbstractOral cancer accounts for 95% of all maxillofacial malignant neoplasm. Presently, surgery and radiation (with and without chemotherapy) are the major treatments for oral cancer; however it met with limited therapeutic outcome. Overcoming the multidrug resistance and finding new therapeutic agents for oral cancer treatment are some of the serious challenges. Small molecule, TH287 potently and selectively inhibits the MTH1 protein in cells and could act as a ne...
Source: Colloids and Surfaces B: Biointerfaces - October 23, 2018 Category: Biochemistry Source Type: research

Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept
Biochem Biophys Res Commun. 2023 Apr 28;665:19-25. doi: 10.1016/j.bbrc.2023.04.109. Online ahead of print.ABSTRACTSN-38, an active metabolite of irinotecan (CPT-11), is thought to circulate enterohepatically via organic anion-transporting polypeptides (OATPs), UDP-glucuronyl transferases (UGTs), multidrug resistance-related protein 2 (MRP2), and breast cancer resistance protein (BCRP). These transporters and enzymes are expressed in not only hepatocytes but also enterocytes. Therefore, we hypothesized that SN-38 circulates between the intestinal lumen and the enterocytes via these transporters and metabolic enzymes. To tes...
Source: Biochemical and Biophysical Research communications - May 6, 2023 Category: Biochemistry Authors: Larasati Martha Akane Nakata Shinnosuke Furuya Wangyang Liu Xieyi Zhang Kenta Mizoi Takuo Ogihara Source Type: research

Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.
CONCLUSIONS: Overexpression of LncRNA PVT1 in gastric carcinoma promotes the development of MDR, suggesting an efficacious target for reversing MDR in gastric cancer therapy. PMID: 25956062 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - May 5, 2015 Category: Biochemistry Authors: Zhang XW, Bu P, Liu L, Zhang XZ, Li J Tags: Biochem Biophys Res Commun Source Type: research

Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells
Publication date: 1 April 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 140 Author(s): Jijin Gu, Junguo Hao, Xiaoling Fang, Xianyi Sha Generally, the major obstacles for efficient gene delivery are cellular internalization and endosomal escape of nucleic acid such as plasmid DNA (pDNA) or small interfering RNA (siRNA). We previously developed Pluronic P123 modified polypropyleneimine (PPI)/pDNA (P123-PPI/pDNA) polyplexes as a gene delivery system. The results showed that P123-PPI/pDNA polyplexes revealed higher transfection efficiency than PPI/pDNA polyplexes in multidrug resistant breast cancer cells. A...
Source: Colloids and Surfaces B: Biointerfaces - January 11, 2016 Category: Biochemistry Source Type: research

Role of DDX53 in taxol-resistance of cervix cancer cells in  vitro.
In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated. In taxol-resistant HelaTR cells, DDX53 was significantly increased as compared to the parental HeLa cells. HelaTR cells also showed upregulation of multidrug resistant gene MDR1, invasive characteristics and decreased apoptosis. In addition, increased autophagy level was observed in HelaTR cells. Overexpression of DDX53 in HeLa and SiHa markedly led to greater resistance to taxol and cisplatin, whereas knockdown of DDX53 in HelaTR cells restored sensitivity, demonstrating that DDX53 regulated taxol resistance in cervix cancer cell...
Source: Biochemical and Biophysical Research communications - November 22, 2018 Category: Biochemistry Authors: Park SY, Kim WJ, Byun JH, Lee JJ, Jeoung D, Park ST, Kim Y Tags: Biochem Biophys Res Commun Source Type: research

Activation of EMT in colorectal cancer by MTDH/NF- κB p65 pathway.
This study tries to investigate the effect of MTDH gene up-regulation on the activation of EMT in colorectal cancer (CRC) cells and identify the role of NF-κB p65. The CaCO2 cells were divided into three groups: one control group of cultured CaCO2 cells (C1), and two groups of CaCO2 cells co-transfected using human MTDH expression plasmid with either siRNA targeting human NF-κB p65 or its negative control (C2 and C3 respectively). The gene modification was confirmed by qPCR and the effect of gene modification on CRC aggravation was studied. MTDH up-regulation significantly promoted CRC cell proliferation, activated anaer...
Source: Molecular and Cellular Biochemistry - February 28, 2019 Category: Biochemistry Authors: El-Ashmawy NE, El-Zamarany EA, Khedr EG, Abo-Saif MA Tags: Mol Cell Biochem Source Type: research