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Specialty: Neurology
Condition: Patent Foramen Ovale

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Total 305 results found since Jan 2013.

Recurrent stroke predictors differ in medically treated patients with pathogenic vs other PFOs
Conclusion: Predictors of recurrence differ when PFO relatedness is classified by the RoPE score, suggesting that patients with CS and PFO form a heterogeneous group with different stroke mechanisms. Echocardiographic features were only associated with recurrence in the high RoPE score group.
Source: Neurology - July 14, 2014 Category: Neurology Authors: Thaler, D. E., Ruthazer, R., Weimar, C., Mas, J.-L., Serena, J., Di Angelantonio, E., Papetti, F., Homma, S., Mattle, H. P., Nedeltchev, K., Mono, M.-L., Jaigobin, C., Michel, P., Elkind, M. S. V., Di Tullio, M. R., Lutz, J. S., Griffith, J., Kent, D. M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology ARTICLE Source Type: research

Routine troponin measurements are unnecessary in acute ischemic stroke evaluations (P4.285)
CONCLUSIONS: Troponin elevation in patients with ischemic stroke is not caused by acute myocardial ischemia unless iatrogenic in the setting of vasopressor administration. Serum troponins should be measured based on clinical context rather than routinely in all acute ischemic stroke patients.Disclosure: Dr. Ali has nothing to disclose. Dr. Young has nothing to disclose. Dr. Rabinstein has received royalty payments from Elsevier and Oxford University Press. Dr. Rabinstein has received research support from DJO Global. Dr. Flemming has nothing to disclose. Dr. Fugate has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ali, F., Young, J., Rabinstein, A., Flemming, K., Fugate, J. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Ischemic Stroke Care Source Type: research

Potential new uses of non-vitamin K antagonist oral anticoagulants to treat and prevent stroke
Conclusion: There may be a role for NOACs in stroke prevention and treatment beyond atrial fibrillation. Randomized controlled trials are needed to compare NOACs to current stroke prevention and treatment strategies in certain subgroups of patients with cerebrovascular disease.
Source: Neurology - September 21, 2015 Category: Neurology Authors: Yaghi, S., Kamel, H., Elkind, M. S. V. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Infarction, Cerebral venous thrombosis VIEWS & amp;amp; REVIEWS Source Type: research

Prothrombotic States and Ischemic Stroke in the Young (P3.231)
Conclusions: There is no association between prothrombotic risk factors (analyzed individually or as a group) and idiopathic ischemic stroke in the young, even in those with a PFO or with migraine.Disclosure: Dr. Boudjani has nothing to disclose. Dr. Lanthier has received compensation for activities with Bristol-Myers-Squibb, Sanofi-Aventis, Boehringer-Ingelheim, and Astra-Zeneca as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boudjani, H., Lanthier, S. Tags: Stroke in the Young Source Type: research

Practice advisory: Recurrent stroke with patent foramen ovale (update of practice parameter): Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Conclusions: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0.13%, 95% confidence interval [CI] –2.2% to 2.0%). Percutaneous PFO closure with the AMPLATZER PFO Occluder possibly decreases the risk of recurrent stroke (RD –1.68%, 95% CI –3.18% to –0.19%), possibly increases the risk of new-onset atrial fibrillation (AF) (RD 1.64%, 95% CI 0.07%–3.2%), and is highly likely to be associated with a procedural complication risk of 3.4% (95% CI 2.3%–5%). There is insufficient evidence to d...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Messe, S. R., Gronseth, G., Kent, D. M., Kizer, J. R., Homma, S., Rosterman, L., Kasner, S. E. Tags: All Cerebrovascular disease/Stroke SPECIAL ARTICLE Source Type: research

Stroke in young adults: Five new things
Purpose of review The incidence of stroke in young adults is increasing, mainly driven by an increasing incidence of ischemic stroke in this population. We provide new information that has been recently presented regarding the risk factor prevalence, some specific etiologic causes, and management strategies in ischemic stroke in this population. Recent findings Recent studies indicate a rapid increase in traditional risk factors in young adults. New information regarding the management of patent foramen ovale in cryptogenic stroke and cervical artery dissection is available. Summary Stroke in young adults is a rapidly gr...
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: Bhatt, N., Malik, A. M., Chaturvedi, S. Tags: Stroke in young adults, Stroke prevention, All Cerebrovascular disease/Stroke, Carotid artery dissection Review Source Type: research

Synthetic Cannabis and Acute Ischemic Stroke
We describe 2 cases that introduce a previously unreported association between synthetic cannabis use and ischemic stroke in young adults. A 22-year-old woman presented with dysarthria, left hemiplegia, and left hemianesthesia within hours of first use of synthetic cannabis. She was healthy and without identified stroke risk factors other than oral contraceptive use and a patent foramen ovale without venous thromboses. A 26-year-old woman presented with nonfluent aphasia, left facial droop, and left hemianesthesia approximately 12 hours after first use of synthetic cannabis. Her other stroke risk factors included migraine ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Miya E. Bernson-Leung, Lester Y. Leung, Sandeep Kumar Tags: Case Reports Source Type: research

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Guideline
The aim of this updated guideline is to provide comprehensive and timely evidence-based recommendations on the prevention of future stroke among survivors of ischemic stroke or transient ischemic attack. The guideline is addressed to all clinicians who manage secondary prevention for these patients. Evidence-based recommendations are provided for control of risk factors, intervention for vascular obstruction, antithrombotic therapy for cardioembolism, and antiplatelet therapy for noncardioembolic stroke. Recommendations are also provided for the prevention of recurrent stroke in a variety of specific circumstances, includi...
Source: Stroke - June 23, 2014 Category: Neurology Authors: Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., Johnston, S. C., Kasner, S. E., Kittner, S. J., Mitchell, P. H., Rich, M. W., Richardson, D., Schwamm, L. H Tags: AHA Statements and Guidelines AHA/ASA Guideline Source Type: research

Recurrent Stroke and Patent Foramen Ovale: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— Our findings indicate that medically treated patients with PFO do not have a higher risk for recurrent cryptogenic cerebrovascular events, compared with those without PFO. No relation between the degree of PFO and the risk of future cerebrovascular events was identified.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Katsanos, A. H., Spence, J. D., Bogiatzi, C., Parissis, J., Giannopoulos, S., Frogoudaki, A., Safouris, A., Voumvourakis, K., Tsivgoulis, G. Tags: Acute Cerebral Infarction Clinical Sciences Source Type: research

Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram
Abstract Although the association between patent foramen ovale and ischemic stroke is controversial, the evaluation for a right-to-left shunt remains part of the standard workup for cryptogenic stroke. Transthoracic and transesophageal echocardiogram (TTE and TEE) are the screening test and gold standard to evaluate for right-to-left shunt, respectively. Studies comparing TTE or TEE to transcranial Doppler (TCD) have shown that 15–25 % of patients test positive for right-to-left shunt on TCD but are negative on TTE or TEE. We sought to further explore this phenomenon in patients with recent ischemic stroke. Bet...
Source: Translational Stroke Research - July 25, 2015 Category: Neurology Source Type: research

Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale Clinical Sciences
Conclusions—Approximately 1 in 14 patients who underwent percutaneous transcatheter PFO closure after ischemic stroke or TIA experienced a serious periprocedural adverse outcome or death. The risk of adverse outcomes was highest in older patients and in those with preceding ischemic stroke.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Alexander E. Merkler, Gino Gialdini, Shadi Yaghi, Peter M. Okin, Costantino Iadecola, Babak B. Navi, Hooman Kamel Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures Original Contributions Source Type: research

Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke
Conclusion: In patients with unexplained stroke, AF was detected by ILR in 25.5%. Predictors of AF were identified, which may help to target investigations. ILRs may have a central role in the future in the investigation of patients with unexplained stroke.
Source: Neurology - April 22, 2013 Category: Neurology Authors: Cotter, P. E., Martin, P. J., Ring, L., Warburton, E. A., Belham, M., Pugh, P. J. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Cardiac; see Cerebrovascular Disease/Cardiac ARTICLE Source Type: research

Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Guideline
The aim of this updated statement is to provide comprehensive and timely evidence-based recommendations on the prevention of stroke among individuals who have not previously experienced a stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches to atherosclerotic disease of the cervicocephalic circulation, and antithrombotic treatments for preventing thrombotic and thromboembolic stroke. Further recommendations are provided for genetic and pharmacogenetic testing and for the prevention of stroke in a variety of other specific circumstances, ...
Source: Stroke - November 24, 2014 Category: Neurology Authors: Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., Goldstein, L. B., Greenberg, S. M., Horvath, S. E., Iadecola, C., Jauch, E. C., Moore, W. S., Wilson Tags: AHA Statements and Guidelines AHA/ASA Guideline Source Type: research

Toward a better understanding of PFO and stroke risk
A patent foramen ovale (PFO) is a remnant of the fetal circulation and may be found in approximately 25% of adults.1 Multiple case-control studies have demonstrated an association between PFO and cryptogenic ischemic stroke, particularly in younger patients.2 The mechanism for the association is presumed to be venous thromboembolism through the PFO and into the cerebral circulation (i.e., paradoxical embolization).3 Randomized studies of percutaneous PFO closure devices for secondary stroke prevention have been in progress for years with slow enrollment because of off-label use of atrial septal defect closure devices.4,5 T...
Source: Neurology - August 12, 2013 Category: Neurology Authors: Messe, S. R., Kernan, W. N. Tags: Stroke in young adults, Stroke prevention, Prognosis, Embolism EDITORIALS Source Type: research

Ischemic Stroke and Patent Foramen Ovale: Risk Factors and Genetic Profile
Conclusions: We found that F2, which previously has been described as being a possible link between PFO and ICVD, was significantly associated with ICVD and PFO. There was also a trend toward an association between 2 other polymorphisms in the APO-CIII gene and PFO and ICVD.
Source: Journal of Stroke and Cerebrovascular Diseases - July 12, 2012 Category: Neurology Authors: Maria Lantz, Christina Sjöstrand, Konstantinos Kostulas Tags: Original Articles Source Type: research