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McConnell ’ s Bid to Downplay Freezes Undermined by History of Politicians Lying About Their Health
After Senate Minority Leader Mitch McConnell froze during a press conference this month, the Kentucky Republican’s second such episode this summer, his office released a note from the Capitol physician intended to calm those worried about his ability to continue at his job. Dr. Brian Monahan told McConnell in the letter that there was “no evidence that you have a seizure disorder or that you experienced a stroke, TIA or movement disorder such as Parkinson’s disease.” Monahan suggested the episodes may be related to the Leader’s concussion in March or to dehydration.  [time-brightcove n...
Source: TIME: Health - September 11, 2023 Category: Consumer Health News Authors: Mini Racker Tags: Uncategorized Congress Source Type: news

Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson's disease
Biomed Pharmacother. 2023 Jan 20;159:114268. doi: 10.1016/j.biopha.2023.114268. Online ahead of print.ABSTRACTParkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various aspects of the mitochondria including the generation of ROS, biogenesis, dynamics, mitophagy etc. Mitochondrial dynamics are regulated through the inter and intracellular movement which impairs mitochondrial trafficking within and between cells. This inter and intracellular mitochondrial movement plays a significant role in maintainin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2023 Category: Drugs & Pharmacology Authors: Rachit Jain Nusrat Begum Kamatham Pushpa Tryphena Shashi Bala Singh Saurabh Srivastava Sachchida Nand Rai Emanuel Vamanu Dharmendra Kumar Khatri Source Type: research

The Therapeutic Potential of Mitochondria Transplantation Therapy in Neurodegenerative and Neurovascular Disorders
Curr Neuropharmacol. 2022 Sep 8. doi: 10.2174/1570159X05666220908100545. Online ahead of print.ABSTRACTNeurodegenerative and neurovascular disorders affect millions of people worldwide and account for a large and increasing health burden on the general population. Thus, there is a critical need to identify potential disease-modifying treatments that can prevent or slow the disease progression. Mitochondria are highly dynamic organelles and play an important role in energy metabolism and redox homeostasis, and mitochondrial dysfunction threatens cell homeostasis, perturbs energy production, and ultimately leads to cell deat...
Source: Current Neuropharmacology - September 12, 2022 Category: Drugs & Pharmacology Authors: Mohammad Moshahid Khan Hector G Paez Christopher R Pitzer Stephen E Alway Source Type: research

Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research

Exploring the role of stem cell therapy in treating neurodegenerative diseases: Challenges and current perspectives
Curr Stem Cell Res Ther. 2021 Aug 9. doi: 10.2174/1574888X16666210810103838. Online ahead of print.ABSTRACTSeveral human neurological disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis; Huntington's disease, spinal cord injury, multiple sclerosis, and brain stroke, are caused by the injury to neurons or glial cells. The recent years have witnessed the successful generation of neurons and glia cells driving efforts to develop stem-cell-based therapies for patients to combat a broad spectrum of human neurological diseases. The inadequacy of suitable cell types for cell replacement thera...
Source: Current Stem Cell Research and Therapy - February 9, 2022 Category: Stem Cells Authors: Nidhi Puranik Ananta Prasad Arukha Shiv Kumar Yadav Dhananjay Yadav Jun O Jin Source Type: research

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