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The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research

Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms
In conclusion, oral MA at different doses protected against PD via distinct mechanisms related to GM. Nevertheless, our study lacked in-depth investigations of the underlying mechanisms involved; future studies will be designed to further delineate the signaling pathways involved in the interactive actions between different doses of MA and GM.PMID:37418977 | DOI:10.1016/j.biopha.2023.115100
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2023 Category: Drugs & Pharmacology Authors: Xu Cao Zhong-Rui Du Xin Liu Xiong Wang Chong Li Sai-Nan Zhou Jia-Rui Liu Ping-Yi Xu Jun-Li Ye Qing Zhao Fang Zhao Ka-Hing Wong Xiao-Li Dong Source Type: research

Early changes of fecal short-chain fatty acid levels in patients with mild cognitive impairments
CONCLUSION: Reductions in fecal SCFAs were observed in patients with MCI compared with NC. Reduced fecal SCFAs were negatively associated with Aβ deposition in cognition-related brain regions in MCI group. Our findings suggest that gut metabolite SCFAs have the potential to serve as early diagnostic biomarkers for distinguishing patients with MCI from NC and could serve as potential targets for preventing AD.PMID:37144597 | DOI:10.1111/cns.14252
Source: CNS Neuroscience and Therapeutics - May 5, 2023 Category: Neuroscience Authors: Chao Gao Binyin Li Yixi He Pai Huang Juanjuan Du Guiying He Pingchen Zhang Huidong Tang Shengdi Chen Source Type: research

Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson's disease model by AMPK-mediated autophagy
Folia Neuropathol. 2022;60(3):329-337. doi: 10.5114/fn.2022.118796.ABSTRACTParkinson's disease (PD) is a well-known neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, and oxidative stress and neuroinflammation are also associated with the pathogenesis of PD. Mitochonic acid 5 (MA-5), an analogue of indole-3-acetic acid, exerts key protective roles in inhibiting apoptosis, oxidative stress and neuroinflammation in multiple diseases. However, whether MA-5 can be beneficial for PD remains unclear. Hence, the aim of this study was to investigate the neuroprotective role of MA-5 in PD. In the ...
Source: Folia Neuropathologica - November 16, 2022 Category: Pathology Authors: Juan Wan Yijiang Gao Jian Tan Shanqing Yi Kailiang Huang Yao Liu Dong Chang Jiali Xie Shuangxi Chen Heng Wu Source Type: research

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