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Research Progress on the Mechanisms of Central Post-Stroke Pain: A Review
Cell Mol Neurobiol. 2023 May 11. doi: 10.1007/s10571-023-01360-6. Online ahead of print.ABSTRACTCentral Post-Stroke Pain (CPSP) is a primary sequelae of stroke that can develop in the body part corresponding to the cerebrovascular lesion after stroke, most typically after ischemic stroke but also after hemorrhagic stroke. The pathogenesis of CPSP is currently unknown, and research into its mechanism is ongoing. To summarize current research on the CPSP mechanism and provide guidance for future studies. Use "central post-stroke pain," "stroke AND thalamic pain," "stroke AND neuropathic pain," "post-stroke thalamic pain" as ...
Source: Cellular and Molecular Neurobiology - May 11, 2023 Category: Cytology Authors: Yupei Cheng Bangqi Wu Jingjie Huang Yameng Chen Source Type: research

Secondary Pathology of the Thalamus after Focal Cortical Stroke in Rats is not Associated with Thermal or Mechanical Hypersensitivity and is Not Alleviated by Intra-Thalamic Post-Stroke Delivery of Recombinant CDNF or MANF.
Abstract A stroke affecting the somatosensory pathway can trigger central post-stroke pain syndrome (CPSP). The symptoms often include hyperalgesia, which has also been described in rodents after the direct damage of the thalamus. Previous studies have shown that hemorrhagic stroke or ischemia caused by vasoconstriction in the thalamus induces increased pain sensitivity. We investigated whether inducing secondary damage in the thalamus by a cortical stroke causes similar pain hypersensitivity as has previously been reported with direct ischemic injury. We induced a focal cortical ischemia-reperfusion injury in mal...
Source: Cell Transplantation - April 29, 2019 Category: Cytology Authors: Anttila JE, Pöyhönen S, Airavaara M Tags: Cell Transplant Source Type: research

Multiple Cell Transplant for Stroke Patients Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke.
Abstract Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of ten consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were 6 males and 4 females. Their age ranged from 42 to 87 years and course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and 4 patients suffered a brain hemorrhage. The olfactory ensh...
Source: Cell Transplantation - August 29, 2013 Category: Cytology Authors: Chen L, Xi H, Huang H, Zhang F, Liu Y, Chen D, Xiao J Tags: Cell Transplant Source Type: research

Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model
CONCLUSION: The site of C7 neurotomy affects MPWT and spinal cord glial proliferation in rats with MCAO. Nerve division closer to intervertebral foramen resulted in lower MPWT and higher degree of glial proliferation in the spinal cord.PMID:35371367 | PMC:PMC8967577 | DOI:10.1155/2022/7446482
Source: Cell Research - April 4, 2022 Category: Cytology Authors: Zhenpeng Li Jintao Fang Jiantao Yang Bengang Qin Wenting He Jian Qi Qingtang Zhu Honggang Wang Liqiang Gu Source Type: research

Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
Neural Regen Res. 2023 Jun;18(6):1165-1178. doi: 10.4103/1673-5374.357903.ABSTRACTT cells are essential for a healthy life, performing continuously: immune surveillance, recognition, protection, activation, suppression, assistance, eradication, secretion, adhesion, migration, homing, communications, and additional tasks. This paper describes five aspects of normal beneficial T cells in the healthy or diseased brain. First, normal beneficial T cells are essential for normal healthy brain functions: cognition, spatial learning, memory, adult neurogenesis, and neuroprotection. T cells decrease secondary neuronal degeneration,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Mia Levite Source Type: research

Expression of Macrophage Migration Inhibitory Factor in the Mouse Neocortex and Posterior Piriform Cortices During Postnatal Development.
Abstract Macrophage migration inhibitory factor (MIF) functions as a pleiotropic protein, participating in a vast array of cellular and biological processes. Abnormal expression of MIF has been implicated in many neurological diseases, including Parkinson's disease, epilepsy, Alzheimer's Disease, stroke, and neuropathic pain. However, the expression patterns of mif transcript and MIF protein from the early postnatal period through adulthood in the mouse brain are still poorly understood. We therefore investigated the temporal and spatial expression of MIF in the mouse neocortex during postnatal development in deta...
Source: Cellular and Molecular Neurobiology - August 14, 2014 Category: Cytology Authors: Zhang W, Li L, Wang J, An L, Hu X, Xie J, Yan R, Chen S, Zhao S Tags: Cell Mol Neurobiol Source Type: research

No pain, no gain: Lack of exercise obstructs neurogenesis.
In this study, we discussed how immobilization-induced disuse atrophy, using the hindlimb suspension model, affects neurogenesis in rats. The overarching hypothesis is that immobilization suppresses neurogenesis by reducing the circulating growth or trophic factors, such as vascular endothelial growth factor or brain-derived neurotrophic factor. That immobilization alters neurogenesis and stem cell differentiation in the CNS requires characterization of the stem cell microenvironment by examining the trophic and growth factors, as well as stressrelated proteins that have been implicated in exercise-induced neurogenesis. Al...
Source: Cell Transplantation - March 24, 2015 Category: Cytology Authors: Watson N, Ji X, Yasuhara T, Date I, Kaneko Y, Tajiri N, Borlongan CV Tags: Cell Transplant Source Type: research

Pressure-Volume Relationships in the Spinal Canal and Potential Neurological Complications After Epidural Fluid Injections
Front Pain Res (Lausanne). 2022 Jul 7;3:884277. doi: 10.3389/fpain.2022.884277. eCollection 2022.ABSTRACTHigh-volume fluid injections into the spinal canal may lead to severe neurological complications. But when anatomical or pathological conditions in the spinal canal are unfavorable, even small volume epidural injections can cause dangerously high epidural, subarachnoid, and intracranial pressures or pressure gradients. Data obtained from the scientific literature and direct clinical observation are used to derive a first-order approximation of epidural, subarachnoid, and intracranial pressure responses to epidural fluid...
Source: Cell Research - July 25, 2022 Category: Cytology Authors: Hemmo Bosscher Source Type: research

Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review
Transl Stroke Res. 2022 Sep 15. doi: 10.1007/s12975-022-01080-x. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) is a major health burden that accounts for approximately 5% of all strokes. The most common cause of a non-traumatic SAH is the rupture of a cerebral aneurysm. The most common symptom associated with SAH is a headache, often described as "the worst headache of my life." Delayed cerebral ischemia (DCI) is a major factor associated with patient mortality following SAH and is often associated with SAH-induced cerebral vasospasm (CV). Cannabidiol (CBD) is emerging as a potential drug for many therapeutic...
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Nicholas Henry Justin F Fraser Joseph Chappell Tamra Langley Jill M Roberts Source Type: research

Predicting Pain in People With Sickle Cell Disease in the Day Hospital Using the Commercial Wearable Apple Watch: Feasibility Study
CONCLUSIONS: The strong performance of the model in all metrics validates feasibility and the ability to use data collected from a noninvasive device, the Apple Watch, to predict the pain scores during VOCs. It is a novel and feasible approach and presents a low-cost method that could benefit clinicians and individuals with sickle cell disease in the treatment of VOCs.PMID:36917171 | DOI:10.2196/45355
Source: Cell Research - March 14, 2023 Category: Cytology Authors: Rebecca Sofia Stojancic Arvind Subramaniam Caroline Vuong Kumar Utkarsh Nuran Golbasi Olivia Fernandez Nirmish Shah Source Type: research