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Specialty: Research
Condition: Multiple Sclerosis

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Total 26 results found since Jan 2013.

Use of E-Selectin Tolerization as Treatment for Immunological and Vascular-Related Disorders
This technology relates to the mucosal delivery (e.g. intranasal) of an E-selectin fragment as a tolerization agent for the prevention and treatment of immunological and vascular-related disorders, including stroke and multiple sclerosis (MS) as well as rare or orphan diseases involving vascular modulated disorders. E-selectin is an adhesion molecule that is expressed on endothelial cells lining blood vessels in response to certain localized cytokines, making the endothelial surface pro-coagulant, pro-inflammatory and/or immunoreactive. Such changes on the endothelial surface have been linked to the development of vascula...
Source: NIH OTT Licensing Opportunities - April 1, 2001 Category: Research Authors: admin Source Type: research

Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains of RF pulses interspersed with field gradients to quantify metabolites. The method allows quantification of metabolites and their relaxation rates under specified parameters, which may create new ways of analyzing and interpreting tissue properties or identifying and characte...
Source: NIH OTT Licensing Opportunities - May 23, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Novel Derivatives of Docosahexaenoylethanolamide as Therapeutics for Neuronal Disorders
This technology provides derivatives of Docosahexaenoylethanolamide (synaptamide or DEA) which have increased potency and hydrolysis resistance as compared to DEA (structures of these derivatives are available upon request), as well as methods of using these derivatives to promote neurogenesis, neurite growth, and/or synaptogenesis. Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid that accumulates in the brain during development, has been shown to play a key role in learning and memory development. Studies have also shown that DEA, a metabolite derived from DHA is very potent in accelerating neuronal growth an...
Source: NIH OTT Licensing Opportunities - January 24, 2013 Category: Research Authors: admin Source Type: research

Derivatives of Docosahexaenoylethanolamide (DEA) for Neurogenesis
The invention pertains to derivatives of docosahexaenoylethanolamide (synaptamide or DEA) and their use in inducing neurogenesis, neurite growth, and/or synaptogenesis. As such, these DEA derivatives can be used as therapeutics for neurodegenerative diseases such as traumatic brain injury, spinal cord injury, peripheral nerve injury, stroke, multiple sclerosis, autism, Alzheimer ' s disease, Huntington ' s disease, Parkinson ' s disease, amyotrophic lateral sclerosis. The DEA derivatives of the invention have increased potency and hydrolysis resistance as compared to native DEA. Docosahexaenoic acid (DHA), an n-3 polyunsat...
Source: NIH OTT Licensing Opportunities - January 24, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research

What the Tech? The Management of Neurological Dysfunction Through the Use of Digital Technology
Adv Exp Med Biol. 2021;1317:131-145. doi: 10.1007/978-3-030-61125-5_7.ABSTRACTWorldwide, it is estimated that millions of individuals suffer from a neurological disorder which can be the result of head injuries, ischaemic events such as a stroke, or neurodegenerative disorders such as Parkinson's disease (PD) and multiple sclerosis (MS). Problems with mobility and hemiparesis are common for these patients, making daily life, social factors and independence heavily affected. Current therapies aimed at improving such conditions are often tedious in nature, with patients often losing vital motivation and positive outlook towa...
Source: Advances in Experimental Medicine and Biology - May 4, 2021 Category: Research Authors: Caitlin Carswell Paul M Rea Source Type: research

Recruitment of participants to a multiple sclerosis trial: The CombiRx experience.
CONCLUSION: Participants can be enrolled successfully in a clinical trial for RRMS, but factors affecting the time to achieve the requirements needed to start screening can be unpredictable and problematic. Prospective planning by the sponsors and investigators, use of central institutional review boards (IRBs), master trial agreements and secure remote desktop access to the trial database may expedite trial implementation and participant recruitment. A good scientific research question with flexible study design and active involvement of the clinicians are important factors driving recruitment. Clinical trials can be impl...
Source: Clinical Trials - April 7, 2014 Category: Research Authors: Bhanushali MJ, Gustafson T, Powell S, Conwit RA, Wolinsky JS, Cutter GR, Lublin FD, Cofield SS Tags: Clin Trials Source Type: research

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated with drowsiness and peripheral neuropathy. Hence, there is intense interest to synthesize, identify and develop safer analogs.Researchers at the National Institute on Aging’s Drug Design and Development Section synthesized novel thalidomide analogs that demonstrate clinical potent...
Source: NIH OTT Licensing Opportunities - December 23, 2015 Category: Research Authors: admin Source Type: research

Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17).
Authors: Zhuo T, Zhou S, Zhang W, Lambertucci C, Volpini R Abstract GPR17 is believed to be a novel target for the development of new therapeutic approaches to human stroke and multiple sclerosis. Hence, the selection of GPR17 ligands may be a potent way to reduce the progression of ischemic damage. New potential ligands for GPR17, mono-, di-, and triphosphate adenosine nucleotides substituted at N6-position with a methyl and a cyclopentyl group were synthesized. The ability of new ligands to bind GPR17 was evaluated using frontal affinity chromatography-mass spectrometry (FAC-MS) method. Cangrelor, MRS2179, and ur...
Source: Medical Science Monitor - February 23, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Postepy Hig Med Dosw 2017; 71:137-148 "Ibudilast: a non ‑ selective phosphodiesterase inhibitor in brain disorders"
Ibudilast (IBD) is a non ‑ selective (3, 4, 10, 11) phosphodiesterase (PDE) inhibitor, used mainly as a bronchodilator for the treatment of bronchial asthma. PDE play a central role in cellular function (e.g. differentiation, synaptic plasticity and inflammatory response) by metabolizing cyclic nucleotides. The results from preclinical and clinical studies indicate that IBD has a broader range of action through suppression of pro ‑ inflammatory cytokines (IL ‑ 6, IL ‑ 1 β , TNF ‑ α ), toll ‑ like receptor 4 blockade (TLR ‑ 4), inhibition of a macrophage migration inhibitory factor (MIF), up ‑ regulation t...
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Review article Source Type: research

Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor.
Authors: von Kügelgen I Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y12 receptor is an important target in pharmacotherapy. The receptor couples to Gαi2 mediating an inhibition of cyclic AMP accumulation and additional downstream events including the activation of phosphatidylinositol-3-kinase and Rap1b proteins. The nucleoside analogue ticagrelor and active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel block P2Y12 receptors and, thereby, inhibit ADP-induced platelet aggreg...
Source: Advances in Experimental Medicine and Biology - September 20, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Rare Neurodegenerative Diseases: Clinical and Genetic Update.
Authors: Matilla-Dueñas A, Corral-Juan M, Rodríguez-Palmero Seuma A, Vilas D, Ispierto L, Morais S, Sequeiros J, Alonso I, Volpini V, Serrano-Munuera C, Pintos-Morell G, Álvarez R, Sánchez I Abstract More than 600 human disorders afflict the nervous system. Of these, neurodegenerative diseases are usually characterised by onset in late adulthood, progressive clinical course, and neuronal loss with regional specificity in the central nervous system. They include Alzheimer's disease and other less frequent dementias, brain cancer, degenerative nerve diseases, encephalitis, epilepsy, genetic brain disorders, head ...
Source: Advances in Experimental Medicine and Biology - December 9, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Co-design of Hand Rehabilitation Exercises for Multiple Sclerosis Using Hand Tracking System.
Authors: Webster A, Poyade M, Rea P, Paul L Abstract Multiple sclerosis (MS) often affects motor function, leading to an adverse effect on daily living. Rehabilitation is important in terms of improving mobility and activities of daily living. Virtual environments (VE) are increasing in popularity within this research area, but research in terms of VE is still rare, for both the upper and lower limb, in people with MS. Leap Motion (LM), a hand motion tracking system, has demonstrated success in stroke research but has yet to be investigated within MS. Following a co-design approach, five participants with MS discus...
Source: Advances in Experimental Medicine and Biology - March 30, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research