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Condition: Chronic Pain
Drug: Acetic Acid
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Total 65 results found since Jan 2013.
Anti-nociceptive and Anti-inflammatory Activities of Visnagin in Different Nociceptive and Inflammatory Mice Models
This study intends to explore the potential to treat pain by inhibiting nociception and inflammation with a safer, non-addictive, effective, and low-cost alternative agent from a natural source, visnagin. In vivo studies have been conducted using male Swiss albino mice as models for this research. Nociception was induced using different chemical and thermal stimuli such as acetic acid, glutamate, capsaicin, and formalin. To check for the anti-inflammatory properties, carrageenan was used to induce inflammation and the activity was assayed using peritoneal cavity leukocyte infiltration analysis and pro-inflammatory cytokine...
Source: Applied Biochemistry and Biotechnology - September 2, 2023 Category: Biochemistry Authors: Xiaobing Qi Kalaivani Aiyasamy Sattam Khulaif Alenezi Ibrahim M Alanazi Mohammed S Alshammari Ibrahim Abdel Aziz Ibrahim Source Type: research
Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice
This study aimed to explore the antinociceptive and anti-pruritic effects of MJS and whether its effects are mediated via the TRPV4 pathway. Mice were treated with MJS (7.5 mg/kg) 0.5 h prior to the initiation of the pain or itch modeling process. The results showed that MJS suppressed pain-like behavior in hot plate, thermal infiltration, glacial acetic acid twisting, and formalin tests. Administration of MJS decreased the pruritus response induced by histamine, C48/80, chloroquine and BAM8-22 within 30 min. MJS reduced scratching bouts and lessened the wiping reaction of mice under TRPV4 activation by GSK101 (10 µg/5 μ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2023 Category: Drugs & Pharmacology Authors: Zhiqiang Qin Lan Xiang Siyu Zheng Yuchen Zhao Yanyan Qin Lei Zhang Lanlan Zhou Source Type: research
Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function
Res Sq. 2023 Mar 8:rs.3.rs-2618133. doi: 10.21203/rs.3.rs-2618133/v1. Preprint.ABSTRACTChronic pancreatitis is a debilitating disease affecting millions worldwide. These patients suffer from bouts of severe pain that are minimally relieved by pain medications and may necessitate major surgeries with high morbidity and mortality. Previously, we demonstrated that "chemical pancreatectomy," a pancreatic intraductal infusion of dilute acetic acid solution, ablated the exocrine pancreas while preserving the endocrine pancreas. Notably, chemical pancreatectomy resolved chronic inflammation, alleviated allodynia in the cerulein p...
Source: Cell Research - March 22, 2023 Category: Cytology Authors: Ranjeet S Kalsi Alexander M Kreger Mohamed Saleh Shiho Yoshida Kartikeya Sharma Joseph Fusco Jami L Saloman Ting Zhang Madison Thomas Anuradha Sehrawat Yan Wang Jason Reif Juliana Mills Sarah Raad Bugra Zengin Ana Gomez Aatur Singhi Sameh Tadros Adam Sliv Source Type: research
Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice
CONCLUSION: We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice. Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension, mediated by neuroglial interactions, MAPK-p38 phosphorylation and the NK1 receptor.PMID:36632316 | PMC:PMC9827584 | DOI:10.3748/wjg.v28.i48.6935
Source: World Journal of Gastroenterology - January 12, 2023 Category: Gastroenterology Authors: Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Boulet é Charl ène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Mo ïse Coëffier Mathieu Meleine Guillaume Gourcerol Source Type: research
