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Prevalence of Complications Associated with Diabetes among Pakistani Patients: A Questionnaire-Based Survey
CONCLUSION: All age groups showed diabetes-associated complications and different abnormal body conditions. However, the age groups ranging from thirty to eighty years showed more complications. The most prevalent complications reported were retinopathy, nephropathy, diabetic wounds on the foot, slow wound healing, seizures, hypertension, neuropathy, skin infections, cardiovascular disorders, liver damage and stroke in both types of diabetic patients. Our survey may aid in pointing out the most prevalent diabetic complications prevailing in our population so that effective treatment options could be developed to reduce the...
Source: Current Diabetes Reviews - January 19, 2022 Category: Endocrinology Authors: Sana Eijaz Sarah Lalpuria Mahrukh Afzal Ariba Yasmeen Sadia Saleem Asma Begum Source Type: research

The extra‐pancreatic effects of GLP‐1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
Abstract The glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) exenatide and liraglutide have been shown to improve glycaemic control and beta‐cell function with a low risk of hypoglycaemia in people with type 2 diabetes. GLP‐1 receptors are also expressed in extra‐pancreatic tissues and trial data suggest GLP‐1RAs also have effects beyond their glycaemic actions. Preclinical studies using native GLP‐1 or GLP‐1RAs provide substantial evidence for cardioprotective effects, while clinical trial data have demonstrated beneficial actions on hypertension and dyslipidaemia in people with type 2 diabetes. Sig...
Source: Diabetes, Obesity and Metabolism - December 24, 2013 Category: Endocrinology Authors: J Seufert, B Gallwitz Tags: Unsolicited Review Article Source Type: research

Diabetes mellitus related biomarker: the predictive role of growth-differentiation factor-15
Publication date: Available online 9 October 2015 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Alexander E. Berezin Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 10, 2015 Category: Endocrinology Source Type: research

Evolution of Pharmacological Obesity Treatments: Focus on Adverse Side‐Effect Profiles
ABSTRACT Pharmacotherapy directed toward reducing body weight may provide benefits for both curbing obesity and lowering the risk of obesity‐associated co‐morbidities. However, many weight loss medications have been withdrawn from the market due to serious adverse effects. Examples include pulmonary hypertension (aminorex), cardiovascular toxicity, e.g. flenfluramine‐induced valvopathy, stroke (phenylpropanolamine), excess non‐fatal cardiovascular events (sibutramine), and neuro‐psychiatric issues (rimonabant ‐ approved in Europe, but not in the US). This negative experience has helped mold the current drug dev...
Source: Diabetes, Obesity and Metabolism - March 1, 2016 Category: Endocrinology Authors: Andrew J. Krentz, Ken Fujioka, Marcus Hompesch Tags: REVIEW ARTICLE Source Type: research

Bariatric surgery and diabetes remission: how far have we progressed?
This article will review the effectiveness of bariatric procedures on the remission and improvement of diabetes and its implicated mechanisms. PMID: 30298760 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - October 12, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Macro- and micro-vascular complications and their determinants among people with type 2 diabetes in Bangladesh
ConclusionDiabetes complications are highly prevalent among type 2 diabetes population in Bangladesh. Prevention strategies should focus on increasing physical activity, weight loss, smoking cessation, and more strict control of hypertension and glycaemic level.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 1, 2019 Category: Endocrinology Source Type: research