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Atrial fibrillation burden and cognitive function; a new horizon in the digital health era?
Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, is a major risk factor for stroke, and is associated with cardiovascular and total mortality. On the other hand, we have increasing evidence today on the association between AF and dementia which is another huge disease burden in the aging society. Numerous retrospective and prospective studies in recent years have reported a strong association between AF, cognitive decline, and dementia [1,2]. Such an association, however, need not be a causal relationship, because all these conditions very likely have a multifactorial interaction with other cardiovascula...
Source: International Journal of Cardiology - February 23, 2023 Category: Cardiology Authors: Ali Serdar Fak Tags: Editorial Source Type: research

REACHing conclusions on the external applicability of the THEMIS into clinical practice
The THEMIS Study (Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients) was a phase 3 randomized, double-blinded, placebo-controlled trial from 2014 to 2016. Patients with angiographically proven coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM), but no prior history of myocardial infarction (MI) or stroke, were randomized 1:1 to either ticagrelor or placebo in addition to low-dose aspirin for a median follow-up of 39.9  months. The randomized population (n = 19,220) had a median age of 66years, 31.4% were women, and there was a high prevalence of concomitant hypertension, dyslipidemi...
Source: International Journal of Cardiology - December 31, 2022 Category: Cardiology Authors: Rahul Gupta, Adriana C. Mares Tags: Editorial Source Type: research

Apparent treatment resistant hypertension and the risk of recurrent cardiovascular events and mortality in patients with established vascular disease
To quantify the relation between apparent treatment resistant hypertension (aTRH) and the risk of recurrent major adverse cardiovascular events (MACE including stroke, myocardial infarction and vascular death) and mortality in patients with stable vascular disease.
Source: International Journal of Cardiology - April 28, 2021 Category: Cardiology Authors: Eline H. Groenland, Michiel L. Bots, Folkert W. Asselbergs, Gert J. de Borst, L. Jaap Kappelle, Frank L.J. Visseren, Wilko Spiering, on behalf of the UCC-SMART Study Group Source Type: research

HIIT for post-COVID patients within cardiac rehabilitation: Response to letter to the editor
We thank Li and colleagues for their comments regarding our recent research into the benefits of incorporating high-intensity interval training (HIIT) into cardiac rehabilitation for patients with coronary artery disease (CAD) [1]. In recent years, HIIT has proven popular in the general community and has been studied across a wide array of cardiovascular (CV)-related disorders, such as hypertension [2,3], stroke [4,5], type II diabetes [6] and non-alcoholic fatty liver disease [7]. This is due to compounding, compelling evidence of the efficacy of HIIT on CV outcomes such as reduced blood pressure, lowered body fat, improv...
Source: International Journal of Cardiology - August 29, 2020 Category: Cardiology Authors: Andrew Keech, Kimberley Way, Katie Holgate, Jennifer Fildes, Praveen Indraratna, Jennifer Yu Tags: Letter to the Editor Source Type: research

Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension
Arterial stiffness may affect antihypertensive response to antihypertensive treatment. However, sufficient clinical evidence is lacking. This longitudinal study aimed to evaluate the effect of baseline arterial stiffness measured by the brachial-ankle pulse wave velocity (baPWV) on response to short-term and long-term enalapril-based treatment in 3310 hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT).
Source: International Journal of Cardiology - February 23, 2020 Category: Cardiology Authors: Y. Fan, W. Gao, J. Li, F. Fan, X. Qin, L. Liu, X. Cheng, X. Xu, X. Wang, B. Wang, Y. Huo Source Type: research

Stroke in pulmonary hypertension: Is it predictable or preventable?
Dear Editor,
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Lingdan Chen, Wenjun He, Fei Liu, Tao Wang Tags: Letter to the Editor Source Type: research

The association between pulmonary hypertension and stroke: a systematic review and meta-analysis
We thank Wang et al. for their comments and for bringing forward the challenges in managing care of patients with pulmonary hypertension (PH) and stroke. We acknowledge multiple possible mechanisms of stroke in patients with PH, and we highlighted them in our work, including paradoxical emboli and atrial fibrillation [1]. However, polycythemia (increased red cells) or other myeloproliferative disorders are considered to be a cause and not a consequence of PH [2,3]. In mice models, Sala et al. have showed that chronic hypoxia could lead to both PH and polycythemia [4].
Source: International Journal of Cardiology - December 11, 2019 Category: Cardiology Authors: Trushil G. Shah, Jaini M. Sutaria, Manav V. Vyas Tags: Letter to the Editor Source Type: research

In reply: Stroke in pulmonary hypertension: Is it predictable or preventable?
We thank Wang et al. for their comments and for bringing forward the challenges in managing care of patients with pulmonary hypertension (PH) and stroke. We acknowledge multiple possible mechanisms of stroke in patients with PH, and we highlighted them in our work, including paradoxical emboli and atrial fibrillation [1]. However, polycythemia (increased red cells) or other myeloproliferative disorders are considered to be a cause and not a consequence of PH [2,3]. In mice models, Sala et al. have showed that chronic hypoxia could lead to both PH and polycythemia [4].
Source: International Journal of Cardiology - December 11, 2019 Category: Cardiology Authors: Trushil G. Shah, Jaini M. Sutaria, Manav V. Vyas Tags: Letter to the Editor Source Type: research

The association between pulmonary hypertension and stroke: A systematic review and meta-analysis
Pulmonary hypertension is associated with atrial fibrillation and paradoxical embolism. Yet, the association between pulmonary hypertension and stroke has not been well studied.
Source: International Journal of Cardiology - July 30, 2019 Category: Cardiology Authors: Trushil G. Shah, Jaini M. Sutaria, Manav V. Vyas Tags: Short communication Source Type: research

Preoperative CT scan for postoperative stroke prediction in minimally invasive mitral valve surgery: Statistical concern for clinical factors in regression analyses
We read with great interest the paper by Leonard et al. [1] online published in IJC in Dec 12, 2018. They included 57 articles (19 CT versus 38 non-CT) with a total of 13,731 patients in the pooled analysis, and tried to identify the potential influential clinical factors of stroke occurrence following minimally invasive mitral valve surgery (MIMVS). Finally, 10 clinical factors (age, female gender, CAD, hypertension, non-CT screening, etc.) have been found to be with significant importance for the incidence of stroke using univariate mete-regression analyses.
Source: International Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Baohui Lou, Chenghui Zhou Tags: Letter to the editor Source Type: research

Sirtuin 5 promotes ischemia/reperfusion-induced blood-brain barrier damage after stroke
Circulating inflammatory cells influence endothelial function, which is important for vascular homeostasis and diseases [1]. Endothelial dysfunction is induced by several cardiovascular risk factors (e.g. hypertension, diabetes, and dyslipidemia) and environmental factors (e.g. hypoxia, infection, smoking, and air pollution) [2]. Recently, we have demonstrated that endothelial AMP-activated protein kinase (AMPK) plays an important role in the regulation of microvascular tone and blood pressure in mice [3].
Source: International Journal of Cardiology - November 10, 2018 Category: Cardiology Authors: Kimio Satoh, Hiroaki Shimokawa Tags: Editorial Source Type: research

A national study of the prevalence and risk factors associated with peripheral arterial disease from China: The China Hypertension Survey, 2012 –2015
Peripheral arterial disease (PAD) is the third leading cause of atherosclerotic vascular morbidity after coronary heart disease and stroke. Epidemiology data of PAD is very limited in low-income and middle-income countries. A national wide survey was conducted from October 2012 to December 2015 to assess the prevalence of PAD in China.
Source: International Journal of Cardiology - October 25, 2018 Category: Cardiology Authors: Zengwu Wang, Xin Wang, Guang Hao, Zuo Chen, Linfeng Zhang, Lan Shao, Ye Tian, Ying Dong, Congyi Zheng, Yuting Kang, Runlin Gao, China hypertension survey investigators Source Type: research

Stroke prevention in atrial fibrillation: State of the art
Stroke prevention is the cornerstone of the management of patients with atrial fibrillation (AF). Individual stroke risk stratification is generally the first step of deciding whether oral anticoagulation (OAC) will benefit patients with AF. Given that existing approaches to the prediction of ‘high risk’ subjects are of limited value, the initial focus should be the identification of ‘low-risk’ patients who do not need antithrombotic therapy. For this, the CHA2DS2-VASc score (congestive heart failure, hypertension, age ≥ 75 [2 points], diabetes mellitus, previous stroke/tra nsient ischemic attack [2 points], ...
Source: International Journal of Cardiology - September 19, 2018 Category: Cardiology Authors: Yan-Guang Li, Gregory Y.H. Lip Tags: Review Source Type: research

Search of multiple markers of organ damage for better cardiovascular risk stratification in hypertension: Role of “SHATS” syndrome in the clinical practice
Essential hypertension is a chronic, asymptomatic disease characterized by sustained and persistent rise in systolic/diastolic blood pressure (BP) levels and increased risk of developing major cardiovascular (CV) complications, including stroke, myocardial infarction, renal disease, congestive heart failure and CV death. Risk of hypertension-related CV complications can be estimated by comprehensive evaluation of individual global CV risk profile, which includes search for CV risk factors and comorbidities, as well as assessment of markers of organ damage (OD).
Source: International Journal of Cardiology - May 11, 2018 Category: Cardiology Authors: Giuliano Tocci, Vivianne Presta, Ilaria Figliuzzi, Massimo Volpe Tags: Editorial Source Type: research

Glycogen synthase kinase 3 β helps heart to pump better in obese patients
Obesity is a growing problem worldwide and is associated with a wide range of comorbidities such as type-2 diabetes (T2D), rheumatoid arthritis, cognitive impairment and dementia, hypertension, stroke and heart failure [1]. The global obesity pandemic affects all age groups. A recent study, based on body mass index (BMI) in over 68 million subjects from 195 countries, suggests that prevalence of metabolic diseases was increased in high BMI subjects globally in the past 20  years [2]. The increased BMI has been shown to be pathogenically related to several diseases including cardiovascular and stroke-related diseases [3].
Source: International Journal of Cardiology - March 23, 2018 Category: Cardiology Authors: Suresh Kumar Verma Source Type: research

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