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Influence of cerebral white matter lesions on the activities of daily living of older patients with mild stroke
ConclusionSevere white matter lesions are a prognostic factor for poor ADL at discharge in older patients with stroke who have mild neurological symptoms. Geriatr Gerontol Int ●●; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - September 1, 2015 Category: Geriatrics Authors: Yutaka Yamashita, Ikuo Wada, Mitsuya Horiba, Kento Sahashi Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Outcome of intravenous recombinant tissue plasminogen activator for acute ischemic stroke in patients aged over 80 years
ConclusionsRt‐PA therapy would appear to improve prognosis in the elderly with ischemic stroke. This suggests that age alone should no longer be a barrier to rt‐PA therapy. Geriatr Gerontol Int 2015; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - August 5, 2015 Category: Geriatrics Authors: Gioia Mione, Xavier Ducrocq, Nathalie Thilly, Jean‐Christophe Lacour, Hervé Vespignani, Sébastien Richard Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of AD and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 30, 2015 Category: Geriatrics Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of Alzheimer disease and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2015 Category: Geriatrics Source Type: research

Incidence of stroke and seizure in Alzheimer's disease dementia
Background: the objective of the study was to estimate and compare the incidence rates of ischaemic and haemorrhagic stroke and seizure among cohorts with and without Alzheimer's disease (AD) dementia. Methods: we conducted a retrospective cohort study using electronic medical records (EMRs) from primary care practices that participated in The Health Improvement Network (THIN) in the United Kingdom from 1 January 1990 to 31 July 2009. For each AD-dementia patient, we selected one general population control patient without AD-dementia matched to one AD-dementia patient on year of birth, sex and physician practice. Findings:...
Source: Age and Ageing - June 22, 2015 Category: Geriatrics Authors: Cook, M., Baker, N., Lanes, S., Bullock, R., Wentworth, C., Arrighi, H. M. Tags: Short Reports Source Type: research

Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study
Conclusion: In the INTERACT2 cohort, older people had more severe ICH and worse outcomes (death, major disability and HRQoL). These data will help guide clinicians manage older people with haemorrhagic stroke. Clinical Trial Registration: http://www.clinicaltrials.gov (NCT00716079).
Source: Age and Ageing - April 27, 2015 Category: Geriatrics Authors: Radholm, K., Arima, H., Lindley, R. I., Wang, J., Tzourio, C., Robinson, T., Heeley, E., Anderson, C. S., Chalmers, J., for the INTERACT2 Investigators Tags: Research Papers Source Type: research

Mortality After Admission to Stroke Unit for Intracerebral Hemorrhage: Effect of Age 80 and Older and Multimorbidity
Source: Journal of the American Geriatrics Society - April 20, 2015 Category: Geriatrics Authors: Paola Forti, Fabiola Maioli, Giorgia Arnone, Valeria Nativio, Silvia Zagnoni, Letizia Riva, Chiara Pedone, Gian Luca Pirazzoli, Maura Coveri, Marco Zoli, Giuseppe Di Pasquale, Gaetano Procaccianti Tags: Letters to the Editor Source Type: research

Intravenous Thrombolysis for Acute Ischemic Stroke in the Elderly: An Italian Cohort Study in a “Real World” Setting
Conclusion Thrombolysis in patients aged >80 years was not associated with significantly increased intracranial hemorrhage. The higher 3-month disability rate observed in octogenarians may be explained by the more severe stroke and higher poststroke disability. Based on the current, “real world setting” study, we advocate the need for a randomized clinical trial to better clarify the efficacy and safety of intravenous thrombolysis for acute ischemic stroke in the elderly.
Source: International Journal of Gerontology - March 10, 2015 Category: Geriatrics Source Type: research

Total and Differential White Blood Cell Counts in Late Life Predict 8‐Year Incident Stroke: The Honolulu Heart Program
ConclusionIn elderly Japanese‐American men, higher total WBC and neutrophil counts were independent predictors of overall stroke, as well as thromboembolic stroke.
Source: Journal of the American Geriatrics Society - March 4, 2015 Category: Geriatrics Authors: Ji Young Huh, George Webster Ross, Randi Chen, Robert D. Abbott, Christina Bell, Bradley Willcox, Lenore Launer, Helen Petrovitch, Brock Kaya, Kamal Masaki Tags: Clinical Investigations Source Type: research

PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice.
In this study, we tested the efficacy of misoprostol in the 12-month-old mice subjected to 1 of 2 complementary ICH models, the collagenase model (primary study) and blood model (secondary study, performed in an independent laboratory). We also investigated its potential mechanism of action. Misoprostol posttreatment decreased brain lesion volume, edema, and brain atrophy and improved long-term functional outcomes. In the collagenase-induced ICH model, misoprostol decreased cellular inflammatory response; attenuated oxidative brain damage and gelatinolytic activity; and decreased high-mobility group box 1 (HMGB1) expressio...
Source: Neurobiology of Aging - January 3, 2015 Category: Geriatrics Authors: Wu H, Wu T, Hua W, Dong X, Gao Y, Zhao X, Chen W, Cao W, Yang Q, Qi J, Zhou J, Wang J Tags: Neurobiol Aging Source Type: research

Vitamin K Antagonists and Cognitive Impairment: Results From a Cross-Sectional Pilot Study Among Geriatric Patients
Conclusions. We found more frequent cognitive impairment associated with the use of VKAs, specifically fluindione, among geriatric patients.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 24, 2014 Category: Geriatrics Authors: Annweiler, C., Ferland, G., Barberger-Gateau, P., Brangier, A., Rolland, Y., Beauchet, O. Tags: Brief Report Source Type: research

Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians
Conclusion: octogenarians and nonagenarians receiving IVT have a similar safety outcome. Asian octogenarians and nonagenarians receiving IVT for ischaemic stroke are not at higher risk of symptomatic ICH and mortality than Western patients.
Source: Age and Ageing - December 4, 2014 Category: Geriatrics Authors: Sun, M.-C., Lai, T.-B., Jeng, J.-S., Sung, S.-F., Sung, P.-S., Tang, S.-C., Chen, W.-L., Chen, C.-H. Tags: Short Reports Source Type: research

Delirium Risk Prediction, Healthcare Use and Mortality of Elderly Adults in the Emergency Department
ConclusionThis risk prediction rule may help identify a group of individuals in the ED at high risk of developing delirium who should undergo screening, but it requires external validation. Identification of delirium in the ED may enable physicians to implement strategies to decrease delirium duration and avoid inappropriate discharge of individuals with acute delirium, improving outcomes.
Source: Journal of the American Geriatrics Society - February 10, 2014 Category: Geriatrics Authors: Maura Kennedy, Richard A. Enander, Sarah P. Tadiri, Richard E. Wolfe, Nathan I. Shapiro, Edward R. Marcantonio Tags: Clinical Investigations Source Type: research

Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry
ConclusionsIn patients treated with rt‐PA, old age is associated with poor functional outcome and in‐hospital mortality. However, the probability of neurological improvement and symptomatic intracranial hemorrhage in older patients is comparable with that in younger patients. Geriatr Gerontol Int 2013; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - October 1, 2013 Category: Geriatrics Authors: Ryu Matsuo, Masahiro Kamouchi, Tetsuro Ago, Jun Hata, Yuji Shono, Junya Kuroda, Yoshinobu Wakisaka, Hiroshi Sugimori, Takanari Kitazono, Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Intravenous thrombolysis in patients aged more than 80 years in the three rural hospitals in southeast Poland: An observational study
ConclusionsOlder age affected the increased times for pre‐ and in‐hospital procedures in rural patients with AIS. Older patients should not be denied the chance to benefit from IV‐thrombolysis, but because of the higher mortality, the application of this therapy should be carefully decided on. Geriatr Gerontol Int 2013; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - August 29, 2013 Category: Geriatrics Authors: Piotr Sobolewski, Waldemar Brola, Jan Stoiński, Wiktor Szczuchniak, Malgorzata Fudala, Renata Hatalska‐Żerebiec, Monika Śledzińska‐Dźwigał Tags: Original Article: Social Research, Planning and Practice Source Type: research

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