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Specialty: Geriatrics
Condition: Hemorrhagic Stroke

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Total 79 results found since Jan 2013.

Association of Delirium Incidence with Visitation Restrictions due to COVID-19 Pandemic in Patients with Acute Cerebrovascular Disease in a Stroke-Unit Setting: A Retrospective Cohort Study
Conclusion: Pandemic-associated visitation restrictions and specifically absolute visitation restrictions are associated with a higher incidence of delirium among stroke-unit patients with acute cerebrovascular disease. Benefit and harm of visitation restrictions should be carefully weighed and adjustments considered for patients otherwise at increased risk for delirium.Gerontology
Source: Gerontology - October 6, 2022 Category: Geriatrics Source Type: research

GM130 protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by regulating autophagy formation
Exp Gerontol. 2022 Mar 21:111772. doi: 10.1016/j.exger.2022.111772. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) disruption following intracerebral hemorrhage (ICH) significantly contributes to neurological deficits. Tight junction (TJ) protein loss in brain endothelial cells leads to BBB disruption. We previously revealed the importance of the Golgi apparatus (GA) in maintaining TJ integrity in mouse brain endothelial (bEnd.3) cells, but the specific mechanisms remain unknown. Herein, we investigated the potential role of the GA in BBB damage and neurological dysfunction after ICH using bEnd.3 cells and hemin t...
Source: Experimental Gerontology - March 25, 2022 Category: Geriatrics Authors: Shuwen Deng Qing Hu Xiqian Chen Qiang Lei Wei Lu Source Type: research

Clinical presentation and assessment of older patients presenting with headache to emergency departments: A multicentre observational study
CONCLUSION: Older patients with headache had different clinical features to the younger cohort and were more likely to have a serious secondary cause of headache than younger adults. There should be a low threshold for investigation in older patients attending ED with non-traumatic headache.PMID:34570422 | DOI:10.1111/ajag.12999
Source: Australasian Journal on Ageing - September 27, 2021 Category: Geriatrics Authors: Sierra Beck Frances B Kinnear Anne Maree Kelly Kevin H Chu Win Sen Kuan Gerben Keijzers Richard Body Mehmet A Karamercan Sharon Klim Tissa Wijeratne Sinan Kamona Colin A Graham Tom Roberts Daniel Horner Said Laribi HEAD Study Group Source Type: research

Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation
ConclusionsWhile the proportion of residents with AF receiving oral anticoagulants at admission increased following the approval of DOACs, over 40% remained untreated. Among those treated, use of a DOAC increased, while warfarin use declined. The impact of these recent treatment patterns on the balance between benefit and harm among residents warrant further investigation.
Source: Drugs and Aging - April 21, 2021 Category: Geriatrics Source Type: research

The Stress Hyperglycemia Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
Source: Clinical Interventions in Aging - March 8, 2021 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research

Mutation analysis of the GLA gene in Chinese patients with intracerebral hemorrhage
In conclusion, our results indicate that the GLA mutation is an uncommon genetic etiology of ICH in China.PMID:33663879 | DOI:10.1016/j.neurobiolaging.2021.01.027
Source: Neurobiology of Aging - March 5, 2021 Category: Geriatrics Authors: Lu Tang Qiong Yang Xiaolu Liu Danyang Tian Chenying Wu Qi Han Xin Yan Shengchao Ding Dongsheng Fan Source Type: research

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management
AbstractStroke is the leading cause of seizures and epilepsy in older adults. Patients who have larger and more severe strokes involving the cortex, are younger, and have acute symptomatic seizures and intracerebral haemorrhage are at highest risk of developing post-stroke epilepsy. Prognostic models, including the SeLECT and CAVE scores, help gauge the risk of epileptogenesis. Early electroencephalogram and blood-based biomarkers can provide information additional to the clinical risk factors of post-stroke epilepsy. The management of acute versus remote symptomatic seizures after stroke is markedly different. The choice ...
Source: Drugs and Aging - February 23, 2021 Category: Geriatrics Source Type: research

New horizons: managing antithrombotic dilemmas in patients with cerebral amyloid angiopathy
AbstractCerebral amyloid angiopathy (CAA) most commonly presents with lobar intracerebral haemorrhage, though also with transient focal neurological episodes, cognitive impairment, as an incidental finding and rarely acutely or subacutely in patients developing an immune response to amyloid. Convexity subarachnoid haemorrhage, cortical superficial siderosis and lobar cerebral microbleeds are the other signature imaging features. The main implications of a diagnosis are the risk of intracerebral haemorrhage and frequent co-existence of antithrombotic indications. The risk of intracerebral haemorrhage varies by phenotype, be...
Source: Age and Ageing - January 22, 2021 Category: Geriatrics Source Type: research

Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review
Conclusionestimates of AF prevalence and factors associated with AC prescription varied extensively. Limited data on outcomes prevent the drawing of definitive conclusions. We recommend panel data collection and systems for linkage to create longitudinal cohorts to provide more robust evidence.
Source: Age and Ageing - December 31, 2020 Category: Geriatrics Source Type: research

The mortality rate of Parkinson ’s disease and related comorbidities: a nationwide population-based matched cohort study in Korea
Conclusionover the 10  year follow-up period, the PD cohort’s mortality rate was 2.5 times higher than the comparison cohort. Understanding the effects that comorbidities have on morality in PD would be useful for predicting mortality in patients with PD.
Source: Age and Ageing - November 20, 2020 Category: Geriatrics Source Type: research

Identification of Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke After Endovascular Therapy Using the Decision Tree Model
Source: Clinical Interventions in Aging - September 8, 2020 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research