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Specialty: Chemistry
Condition: Hemorrhagic Stroke

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Total 89 results found since Jan 2013.

Statins in stroke.
Conclusion: Treatment with statins prevents ischemic stroke, especially in patients with high cardiovascular risk and established atherosclerotic disease. It seems that both lipid lowering and pleiotropic effects contribute to these effects. PMID: 31218948 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - June 18, 2019 Category: Chemistry Authors: Aznaouridis K, Masoura C, Vlachopoulos C, Tousoulis D Tags: Curr Med Chem Source Type: research

Community planning for a "healthy built environment" via a human-environment nexus? A multifactorial assessment of environmental characteristics and age-specific stroke mortality in Hong Kong
In conclusion, urban plans and designs for stroke mortality prevention should implement age-specific health care to neighborhoods with particular population segments.PMID:34543905 | DOI:10.1016/j.chemosphere.2021.132043
Source: Chemosphere - September 20, 2021 Category: Chemistry Authors: Hung Chak Ho Huagui Guo Ta-Chien Chan Yuan Shi Chris Webster Kenneth N K Fong Source Type: research

The emerging role of microRNA in stroke.
Abstract MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that play a pivotal role in post-transcriptional gene regulation by binding to complementary sites in the 3'-untranslated region of messenger RNAs. In the past decade, their role in several human diseases, from cancer to cardiovascular disease, has been established by a wealth of evidence. Stroke is responsible for 10% of deaths worldwide and is one of the leading causes of disability. MiRNAs are involved in stroke risk factors including hypertension, atherosclerosis, atrial fibrillation, diabetes and dyslipidemia. The rol...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Koutsis G, Siasos G, Spengos K Tags: Curr Top Med Chem Source Type: research

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets.
Abstract Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by ischemia due to occlusion of a cerebral artery. Inflammation is known to result as a result of ischemic injury, long thought to be involved in initiating the recovery and repair process. However, work over the past few decades indicates that aspects of this inflammatory response may in fact be detrimental to stroke outcome. Acutely, inflammation appears to have a detrimental effect, and anti-inflammatory treatments have been been ...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Kim JY, Kawabori M, Yenari MA Tags: Curr Med Chem Source Type: research

Glial Fibrillary Acidic Protein Serum Levels Distinguish between Intracerebral Hemorrhage and Cerebral Ischemia in the Early Phase of Stroke Proteomics and Protein Markers
CONCLUSIONS: Serum GFAP was confirmed to be a biomarker indicating ICH in patients presenting with acute stroke symptoms. Very small ICH may be missed owing to less tissue destruction.
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Luger, S., Witsch, J., Dietz, A., Hamann, G. F., Minnerup, J., Schneider, H., Sitzer, M., Wartenberg, K. E., Niessner, M., Foerch, C., for the BE FAST II and the IGNITE Study Groups Tags: General Clinical Chemistry Proteomics and Protein Markers Source Type: research

Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke.
CONCLUSION:: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. PMID: 24650689 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 17, 2014 Category: Chemistry Authors: Leung LY, Chan CP, Leung YK, Jiang HL, Abrigo JM, Wang D, Chung JS, Rainer TH, Graham CA Tags: Clin Chim Acta Source Type: research

Hs-CRP in stroke: A meta-analysis.
CONCLUSIONS: Elevated baseline hs-CRP levels are independently associated with excessive ischaemic stroke risk but exhibit no clear effect on haemorrhagic stroke. PMID: 26633855 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - November 26, 2015 Category: Chemistry Authors: Zhou Y, Han W, Gong D, Man C, Fan Y Tags: Clin Chim Acta Source Type: research

Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: a systematic review
CONCLUSION: This systematic review shows that motor functional recovery can be predicted by 61 independent prognostic molecular biomarkers assessed in the acute phase after a hemorrhagic stroke.PMID:34389283 | DOI:10.1016/j.cca.2021.08.006
Source: International Journal of Clinical Chemistry - August 14, 2021 Category: Chemistry Authors: Jean Alex Matos Ribeiro Luisa Fernanda Garc ía-Salazar C ássia Regina Saade-Pacheco Érika Shirley Moreira Silva Simone Garcia Oliveira Ana Fl ávia Silveira Adriana Sanches Garcia-Ara újo Thiago Luiz Russo Source Type: research

Minocycline Repurposing in Critical Illness: Focus on Stroke.
Abstract Stroke is a devastating disease associated with high morbidity and mortality. Despite the approved indication of systemic thrombolytic therapy in the United States for the acute management of ischemic stroke, its use is limited given a strict eligibility criteria and a risk for hemorrhagic transformation as a feared adverse effect. Many agents have been studied without success for neuroprotection in patients with stroke to reduce vascular injury and improve long-term functional outcomes. Minocycline is a tetracycline antibiotic that shows promise for its neuroprotective effects in multiple animal models a...
Source: Current Topics in Medicinal Chemistry - September 20, 2013 Category: Chemistry Authors: Vivian Liao T, C Forehand C, Hess DC, Fagan SC Tags: Curr Top Med Chem Source Type: research

Neuroprotective Effects of Ginkgolide B against Ischemic Stroke: a Review of Current Literature.
Abstract Extensive evidences have shown the promising effects of Ginkgo biloba consumption on several diseases such as Alzheimer, Parkinson, ischemic stroke, etc. Several studies also reported its beneficial role on motor activity and cognitive function. This species contain unique class of diterpene, namely Ginkgolide B, which possess several pharmacological activities such as protective effect against cardiovascular disease; the most important causes of death worldwide. The promising effects of Ginkgolide B on stroke, both ischemic and hemorrhagic, are suggested by an overwhelming body of scientific evidences. M...
Source: Current Topics in Medicinal Chemistry - June 10, 2015 Category: Chemistry Authors: Nabavi SM, Habtemariam S, Daglia M, Braidy N, Loizzo MR, Tundis R, Nabavi SF Tags: Curr Top Med Chem Source Type: research

Predictive value of thrombospondin-1 for outcomes in patients with acute ischemic stroke.
CONCLUSIONS: Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke. PMID: 26296896 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - August 19, 2015 Category: Chemistry Authors: Gao JB, Tang WD, Wang HX, Xu Y Tags: Clin Chim Acta Source Type: research