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Observational Study of Patients Hospitalized With Neurologic Events After SARS-CoV-2 Vaccination, December 2020-June 2021
Discussion All cases in this study were determined to have at least 1 risk factor and/or known etiology accounting for their neurologic syndromes. Our comprehensive clinical review of these cases supports the safety of mRNA COVID-19 vaccines.
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Kim, C. Y., McNeill, E. N., Young, C., King, F., Clague, M., Caldwell, M., Boruah, A., Zucker, J., Thakur, K. T. Tags: Autoimmune diseases, Post-infectious, Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), COVID-19 Research Article Source Type: research

Peroxiredoxin-3 Plays a Neuroprotective Role in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research Bulletin - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Peroxiredoxin-3 Plays a Neuroprotective Role in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research Bulletin - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia
CONCLUSIONS: Vaccine-induced immune thrombotic thrombocytopenia is a serious complication of vaccination that is not feasible to anticipate or prevent. When the patient presents with sustained headache, neurologic symptoms/signs, abdominal pain, dyspnea, or limb pain/swelling beginning 5–30 days post vaccination, platelet count and d-dimer must be measured, and imaging for thrombosis performed. Confirmation of vaccine-induced immune thrombotic thrombocytopenia diagnosis should be ordered (platelet factor 4/polyanion enzyme-linked immunosorbent assay; platelet factor 4–enhanced platelet activation testing) as treatm...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Review Article Source Type: research

Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice
In this study, ICH was induced in C57BL/6 J mice by injection of collagenase VII, while the overexpression of Nrn in the striatum was induced by an adeno-associated virus serotype 9 (AAV9) vector. We found that compared with GFP-ICH mice, Nrn-ICH mice showed improved performance in the corner, cylinder and forelimb tests after ICH, and showed less weight loss and more rapid weight recovery. Overexpression of Nrn reduced brain lesions, edema, neuronal death and white matter and synaptic integrity dysfunction caused by ICH. Western blot results showed that phosphorylated PERK and ATF4 were significantly inhibited, while phos...
Source: Neurobiology of Disease - May 31, 2021 Category: Neurology Authors: Junmei Lu Zhaoyang Li Qianru Zhao Dongdong Liu Yan-Ai Mei Source Type: research

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