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TACTICS - Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an 'implementation intervention in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke
Introduction Stroke reperfusion therapies, comprising intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), are best practice treatments for eligible acute ischemic stroke patients. In Australia, EVT is provided at few, mainly metropolitan, comprehensive stroke centres (CSC). There are significant challenges for Australia’s rural and remote populations in accessing EVT, but improved access can be facilitated by a ‘drip and ship’ approach. TACTICS (Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship) aims to test whether a multicomponent, multidisciplinary impleme...
Source: BMJ Open - February 11, 2022 Category: General Medicine Authors: Ryan, A., Paul, C. L., Cox, M., Whalen, O., Bivard, A., Attia, J., Bladin, C., Davis, S. M., Campbell, B. C. V., Parsons, M., Grimley, R. S., Anderson, C., Donnan, G. A., Oldmeadow, C., Kuhle, S., Walker, F. R., Hood, R. J., Maltby, S., Keynes, A., Delcou Tags: Open access, Health services research Source Type: research

Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol
AbstractAneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is important in determining outcome following aSAH. Understanding genetic determinants of outcome will help to improve prognostic modelling, stratify patients in clinical trials and target novel...
Source: Translational Stroke Research - January 6, 2022 Category: Neurology Source Type: research

The burden of undertreatment and non-treatment among patients with non-valvular atrial fibrillation and elevated stroke risk: a systematic review
CONCLUSIONS: Rates of nontreatment and undertreatment among NVAF patients remain high and are associated with preventable cardiovascular events and death. Strategies to increase rates of treatment may improve clinical outcomes.PMID:34632887 | DOI:10.1080/03007995.2021.1982684
Source: Current Medical Research and Opinion - October 11, 2021 Category: Research Authors: Matthew Sussman Geoffrey D Barnes Jennifer D Guo Charles Y Tao John A Gillespie Mauricio Ferri Nicholas Adair Matthew S Cato Ilnaz Shirkhorshidian Manuela Di Fusco Source Type: research

Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol
Introduction Mechanical ventilatory is a crucial element of acute brain injured patients’ management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this setting. Methods and analysis This is an international multicentre prospective observational cohort study. The aim of the ‘multicentre observational study on practice of ventilation in brain injured patients’—the VENTIBRAIN study—is t...
Source: BMJ Open - August 11, 2021 Category: General Medicine Authors: Robba, C., Citerio, G., Taccone, F. S., Galimberti, S., Rebora, P., Vargiolu, A., Pelosi, P., VENTIBRAIN Enlarged Steering committee members, VENTIBRAIN, Mandelli, Mancebo, Stevens, Meyfroidt, Badenes, Torre, Helbok, Suarez, Stocchetti, Abreu, Schultz, Ci Tags: Open access, Intensive care Source Type: research

Clinical Effects of Dual Antiplatelet Therapy or Aspirin Monotherapy after Acute Minor Ischemic Stroke or Transient Ischemic Attack, a Meta-Analysis
CONCLUSIONS: Among patients with acute minor ischemic stroke or TIA, DAPT, as compared with aspirin monotherapy, might offer better effectiveness in terms of ischemic stroke recurrence at the expense of a higher risk of major bleeding. The trade-off between ischemic benefits and bleeding risks should be assessed in tailoring the therapeutic strategies.PMID:34323179 | DOI:10.2174/1381612827666210728102459
Source: Current Pharmaceutical Design - July 29, 2021 Category: Drugs & Pharmacology Authors: Francesco Condello Gaetano Liccardo Giuseppe Ferrante Source Type: research

E-085 Interventional and diagnostic neuroradiology fellowship education in the COVID-19 era
ConclusionElective neurointerventional case numbers decreased as a result of the COVID-19 pandemic, particularly impacting the fourth quarter of the 2019-2020 academic year (April - June). Similarly, there was a sizable decrease in diagnostic neuroradiology case volume during this same time period. The decrease in procedural and diagnostic neuroradiology cases raised concerns regarding the educational experience for both diagnostic and neurointerventional radiology fellows. However, as a result of decreased case volume, fellowship education was rapidly augmented with a wide variety of online webinars, lectures, case confer...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Wilseck, Z., Bamezai, S., Novakovic, N., Copelan, A., Wilseck, J., Srinivasan, A., Pandey, A., Thompson, G., Gemmete, J., Chaudhary, N. Tags: Electronic poster abstracts Source Type: research

AAN: Stroke Occurs in 2.2 Percent of Patients Admitted to ICU With COVID - 19
Cumulative hazard of death increased in association with hemorrhagic stroke, but not with ischemic stroke
Source: Pulmonary Medicine News - Doctors Lounge - April 19, 2021 Category: Respiratory Medicine Tags: Infections, Neurology, Nursing, Pulmonology, Critical Care, Conference News, Source Type: news

Chinese herbal injections combined with rt-PA intravenous thrombolysis for acute ischemic stroke: A systematic review and meta-analysis protocol
Conclusion: The conclusion of the meta-analysis will provide a basis for judging whether CHIs combined with intravenous thrombolysis is an effective measure for the treatment of AIS. Ethics and dissemination: Ethical approval is not needed because this study will be based on data that already published. We will publish the findings of this study in a peer-reviewed journal and related conferences. PROSPERO registration number: CRD42020215546.
Source: Medicine - March 12, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Efficacy and safety of intravenous thrombolysis with alteplase for treating acute ischemic stroke at different time windows: A protocol for systematic review and meta-analysis
Conclusions: This study will provide an evidence-based basis for the clinical efficacy of alteplase for treating AIS by thrombolytic therapy at different time windows. Ethics and dissemination: Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval was not required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences. OSF Registration number: DOI 10.17605 / OSF.IO / K7PHB
Source: Medicine - December 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage: A protocol for a network meta-analysis
Conclusion: This study will provide high quality evidence about effects of different hemostatic agents in patients with sICH. Registration number: CRD42020196039.
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

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