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Inflammatory Bowel Disease and Neurodegenerative Diseases
Gut Liver. 2023 Feb 27. doi: 10.5009/gnl220523. Online ahead of print.ABSTRACTA growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and c...
Source: Gut and Liver - February 27, 2023 Category: Gastroenterology Authors: Jin Sun Kim Mu-Hong Chen Hohui E Wang Ching-Liang Lu Yen-Po Wang Bing Zhang Source Type: research

Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease
Conclusion Compared with matched population controls, children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure. Research to better characterise cardiovascular risk in children and young adults with NAFLD should be prioritised.
Source: Gut - February 7, 2023 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Alkhouri, N., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

Optimising the management of cardiovascular comorbidities in NAFLD patients: its time to (re-) act!
With great interest, we have read the recent article by Simon et al,1 reporting a significant association between non-alcoholic fatty liver disease (NAFLD) and incident major adverse cardiovascular events. The authors found that patients with biopsy-proven NAFLD had a significantly higher incidence of ischaemic heart disease, stroke, congestive heart failure and death due to cardiovascular disease (CVD), when compared with matched controls. An excess in CVD morbidity and mortality was evident across all stages of NAFLD and increased with worsening disease severity. The authors are to be congratulated for conducting such a ...
Source: Gut - October 7, 2022 Category: Gastroenterology Authors: Kasper, P., Lang, S., Demir, M., Steffen, H.-M. Tags: Gut PostScript Source Type: research

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort
Conclusion Compared with matched population controls, patients with biopsy-proven NAFLD had significantly higher incidence of MACE, including IHD, stroke, CHF and CV mortality. Excess risk was evident across all stages of NAFLD and increased with worsening disease severity.
Source: Gut - August 11, 2022 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

Does non-alcoholic fatty liver disease predispose patients to carotid arteriosclerosis and ischemic stroke?
Clin Mol Hepatol. 2022 Jun 22. doi: 10.3350/cmh.2022.0155. Online ahead of print.NO ABSTRACTPMID:35730209 | DOI:10.3350/cmh.2022.0155
Source: Clinical and molecular hepatology - June 22, 2022 Category: Gastroenterology Authors: Qian Jin Rui-Xu Yang Jian-Gao Fan Source Type: research

An elevated FIB-4 score is not associated with cardiovascular events: a longitudinal analysis from 137 842 patients with and without chronic liver disease
Conclusion Our study suggests that the FIB-4 score is not associated with cardiovascular events both in the general population as well as in patients with CLD.
Source: European Journal of Gastroenterology and Hepatology - May 5, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Increased standardised incidence ratio of cardiovascular diseases among colorectal cancer patients
ConclusionsColorectal cancer patients are at an increased risk of developing CVD, especially coronary heart disease, during the first 3  years following colorectal cancer diagnosis.
Source: International Journal of Colorectal Disease - March 17, 2022 Category: Gastroenterology Source Type: research

NAFLD increases Risk of Carotid Atherosclerosis and Ischemic Stroke. An Updated Meta-Analysis with 135,602 Individuals
CONCLUSIONS: This meta-analysis shows that a stepwise increment of steatosis of NAFLD can significantly increase the odds of carotid atherosclerosis and stroke development in NAFLD. More than a third suffer from carotid atherosclerosis and routine assessment of carotid atherosclerosis is quintessential in NAFLD.PMID:35232007 | DOI:10.3350/cmh.2021.0406
Source: Clinical and molecular hepatology - March 2, 2022 Category: Gastroenterology Authors: Ansel Shao Pin Tang Kai En Chan Jingxuan Quek Jieling Xiao Phoebe Tay Margaret Teng Keng Siang Lee Snow Yunni Lin May Zin Myint Benjamin Tan Vijay K Sharma Darren Jun Hao Tan Wen Hui Lim Apichat Kaewdech Daniel Huang Nicholas Ws Chew Mohammad Shadab Siddi Source Type: research

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