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Condition: Ischemic Stroke
Procedure: Anesthesia

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Total 887 results found since Jan 2013.

Predictors and outcome of early neurological deterioration after endovascular thrombectomy: a secondary analysis of the DIRECT-MT trial
Conclusions Postoperative END is associated with adverse functional outcome. Several non-modifiable and modifiable factors can predict END and support future treatment decision-making to improve the potential utility of endovascular thrombectomy. Trial registration number DIRECT-MT ClinicalTrials.gov NCT03469206.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Zhang, M., Xing, P., Tang, J., Shi, L., Yang, P., Zhang, Y., Zhang, L., Peng, Y., Liu, S., Zhang, L., Fu, J., Liu, J., On behalf of the DIRECT-MT Investigators, Liu, Deng, Hong, Ke, Lou, Yin, Wang, Chen, Xu, Li, Wei, Li, Zhu, Sun, Liang, Wang, Wang, Peng, Tags: Ischemic stroke Source Type: research

P158/212 The first pass effect: the initial real-life experience of the University Clinical centre of Serbia
ConclusionDespite shorter time intervals and higher frequency of recanalization rate of the FPE group, no difference was observed in relation to clinical and safety outcomes after 90 days of AIS. In order to better understand the FPE and its predictors, further studies are needed in form of randomized controlled clinical studies.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Mircic, U., Vukasinovic, I., Nedeljkovic, Z., Pirkovic, I., Nestorovic, D., Cvetic, V., Ercegovac, M., Jovanovic, D., Berisavac, I., Stanarcevic, P. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

O35/335 Factors associated with successful recanalization in patients with acute ischemic stroke treated with endovascular thrombectomy - a nationwide register-based observational study
ConclusionThis study explore procedural factors associated with technically successful EVT on nationwide scale.Disclosure of InterestJW received funding from the Crafoord Foundation (#20200548) The Swedish Government (YF-ALF #43435), Region of Skåne research grant (#47455), Skåne university Hospital research grants (#96437 and #96438), VINNOVA (#2020–04841) and AIDA (#2024). JW is a founder and shareholder in Uman Sense AB.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Wasselius, J., Hall, E., Ramgren, B., Andersson, T., Ullberg, T. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

Prognostic Nutritional Index (PNI) as a potential predictor and intervention target for perioperative ischemic stroke: a retrospective cohort study
This study aims to ev...
Source: BMC Anesthesiology - August 10, 2023 Category: Anesthesiology Authors: Min Liu, Miao Sun, Ting Zhang, Peng Li, Jin Liu, Yanhong Liu, Yuxiang Song, Siyuan Liu, Huikai Yang, Zhikang Zhou, Dandan Chang, Guyan Wang, Weidong Mi and Yulong Ma Tags: Research Source Type: research

The Functional Prognosis of Rescue Conscious Sedation During Mechanical Thrombectomy on Patients with Acute Anterior Circulation Ischemic Stroke: A Single-Center Retrospective Study
ConclusionCompared to LA, rescue CS during MT does  not significantly improve the 90 days of good prognosis and reduce the incidence of sICH and mortality in patients with anterior circulation AIS. However, it has a significantly increased risk of poststroke pneumonia (PSP), particularly in patients with dysphagia.
Source: Neurology and Therapy - August 2, 2023 Category: Neurology Source Type: research

E-107 Carotid artery stenting in patients with symptomatic non-stenotic carotid artery disease - a case series
ConclusionsIn this case series performed over a 10-year period at a high-volume stroke center we show that CAS is safe and efficient in patients with SyNC. Previous studies have established safety and effectiveness of CES in patients presenting with SyNC, however there is a paucity of reports in the literature regarding the effect of CAS in this patient population. Recent guidelines have brought specific attention to high-risk plaque characteristics which suggest that plaque instability plays a major role in the onset of ischemic events, regardless of lumen narrowing. Advanced imaging techniques, such as Optical Coherence ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nedelcu, S., Kuhn, A., Singh, J., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-132 Successful mechanical thrombectomy in an 11-year-old patient with emergent large vessel occlusion acute ischemic stroke related to congenital complete heart block and recent covid-19 infection
ConclusionsThis is a first known report of a successful mechanical thrombectomy in a pediatric patient due to a large vessel occlusion related to congenital complete heart block and recent COVID-19 infection.Disclosures J. Ansari: None. D. Mata Canadas: None. M. Ayub: None. J. Caskey: None. P. Simoncini: None. R. Riel-Romero: None. P. Sharma: None. D. Jordan: None. H. Cuellar: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ansari, J., Mata Canadas, D., Ayub, M., Caskey, J., Simoncini, P., Riel-Romero, R., Sharma, P., Jordan, D., Cuellar, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-162 Procedural predictors of early neurologic improvement following endovascular thrombectomy in patients with large vessel occlusion
ConclusionIn a large retrospective database, we found that excellent recanalization, defined as TICI 2C or above, significantly predicted ENI and delta NIHSS of 6 or above within 24 hours of procedure in patients with acute ischemic stroke from a large vessel occlusion.Disclosures M. Al-Kawaz: None. D. Goldman: None. J. Scaggiante: None. K. Yaeger: None. T. Hardigan: None. C. Kellner: None. J. Fifi: None. J. Mocco: None. S. Majidi: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Al-Kawaz, M., Goldman, D., Scaggiante, J., Yaeger, K., Hardigan, T., Kellner, C., Fifi, J., Mocco, J., Majidi, S. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

P-013 The need for speed: reducing endovascular treatment times in ischemic stroke
ConclusionsImproving awareness of process expectations by meeting with stakeholders resulted in a substantial and sustainable decreases in median door to groin puncture and door to first pass times. Implementation of hospital-based PI multidisciplinary team initiatives helped improve our sites work flow and continued to improve our door to 1st pass times.Disclosures H. Shownkeen: None. A. Doerr: None. B. Fill: None. A. Mazumdar: None. D. Pandya: None. K. Buffo: None. A. Stacey: None. T. Iacob: None. L. Stanek: None. J. Carlson: None. L. Spellman: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Shownkeen, H., Doerr, A., Fill, B., Mazumdar, A., Pandya, D., Buffo, K., Stacey, A., Iacob, T., Stanek, L., Carlson, J., Spellman, L. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

European Stroke Organisation (ESO) - European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischemic Stroke
Conclusions MT is the standard of care in patients with LVO-related acute stroke. Appropriate patient selection and timely reperfusion are crucial. Further randomized trials are needed to inform clinical decision-making with regard tothe mothership and drip-and-ship approaches, anesthaesia modalities during MT, and to determine whether MT is beneficial in patients with low stroke severity or large infarct volume.
Source: Journal of NeuroInterventional Surgery - July 14, 2023 Category: Neurosurgery Authors: Turc, G., Bhogal, P., Fischer, U., Khatri, P., Lobotesis, K., Mazighi, M., Schellinger, P. D., Toni, D., de Vries, J., White, P., Fiehler, J. Tags: Standard Standards Source Type: research

Genes, Vol. 14, Pages 1448: Isoflurane Anesthesia & rsquo;s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model
Conclusions: We were able to determine the effects of the duration of anesthesia using isoflurane on the transcriptomes in the brains of rats at 24 h after tMCAO. Thus, specific genome responses may be useful in developing potential approaches to reduce damaged areas after cerebral ischemia and neuroprotection.
Source: Genes - July 14, 2023 Category: Genetics & Stem Cells Authors: Yana Y. Shpetko Ivan B. Filippenkov Alina E. Denisova Vasily V. Stavchansky Leonid V. Gubsky Svetlana A. Limborska Lyudmila V. Dergunova Tags: Article Source Type: research

Impact of anesthesia modalities on functional outcome of mechanical thrombectomy in patients with acute ischemic stroke: a subgroup analysis of DIRECT-MT trial
ConclusionsIn the subgroup analysis of DIRECT-MT, we found no significant difference in the functional outcome at 90  days between general anesthesia and non-general anesthesia, despite the workflow time being significantly delayed for patients with general anesthesia.Clinical trail registration clinicaltrials.gov Identifier: NCT03469206.
Source: European Journal of Medical Research - July 10, 2023 Category: Research Source Type: research

Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia –Reperfusion Injury in Rats
AbstractCerebral ischemic stroke (CIS) has become the second leading cause of death worldwide, which is largely related to cerebral ischemia reperfusion injury (CIRI). Surgical intervention is a reliable treatment for CIS, which predictably causes cerebral reperfusion. Therefore, the choice of anesthetic drugs has important clinical significance. Isoflurane (ISO), one of the most used anesthetics, attenuates cognitive impairment and has brain protective effects. However, the role of isoflurane in regulating autophagy and its regulatory mechanism on inflammation in CIRI are still unclear. The middle cerebral artery occlusio...
Source: Journal of Molecular Neuroscience - June 30, 2023 Category: Neuroscience Source Type: research

Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats
CONCLUSION: Dexmedetomidine has a dose-dependent protective effect on cerebral ischemic injury in rats. The neuroprotective effects of dexmedetomidine are achieved, in part, by reducing the oxidative stress response, inhibiting glial overactivation, and inhibiting expression levels of apoptosis-related proteins.PMID:37235497
Source: Alternative Therapies in Health and Medicine - May 26, 2023 Category: Complementary Medicine Authors: Jianhong Lyu Yang Zhou Min Zhang Lingling Tang Xudan Bao Zaijiao Sun Li Huang Liqin Zhao Source Type: research