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GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner
Transl Stroke Res. 2022 Oct 1. doi: 10.1007/s12975-022-01093-6. Online ahead of print.ABSTRACTNo current treatments target microvascular reperfusion after stroke, which can contribute to poor outcomes even after successful clot retrieval. The G protein-coupled receptor GPR39 is expressed in brain peri-capillary pericytes, and has been implicated in microvascular regulation, but its role in stroke is unknown. We tested the hypothesis that GPR39 plays a protective role after stroke, in part due to preservation of microvascular perfusion. We generated GPR39 knockout (KO) mice and tested whether GPR39 gene deletion worsens cap...
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Yifan Xu Wenri H Zhang Elyse M Allen Lev M Fedorov Anthony P Barnes Zu Yuan Qian Thierno Madjou Bah Yuandong Li Ruikang K Wang Robert E Shangraw Nabil J Alkayed Source Type: research

Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
Neurochem Res. 2022 Mar 22. doi: 10.1007/s11064-022-03544-w. Online ahead of print.ABSTRACTTo investigate the function of hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and Notch receptor 3 (NOTCH3) in ischemic stroke. Stroke models were established by middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) in rats and rat brain microvascular endothelial cells (BMVECs), respectively. Neurological deficit evaluation and 2,3,5-triphenyltetrazolium chloride staining were used to assess cerebral injury. The expression of HEY1 and NOTCH3 was manipulated using gain and loss of function appr...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Tingting Zhu Hongxi Chen Cuihong He Xiaojuan Liu Source Type: research

β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research

Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3
CONCLUSION: Altogether, circPRDX3 inhibited the development of IS by sponging miR-641, hence increasing NPR3 expression and inactivating MAPK pathway. These results may aid in the search of potential therapy targets for IS.PMID:36208650 | DOI:10.1016/j.brainres.2022.148114
Source: Cell Research - October 8, 2022 Category: Cytology Authors: Weiping Chen Yangbo Zhang Min Yin Zhijuan Cheng Dandan Li Xin Luo Xu Liu Jianglong Tu Source Type: research

Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia-reperfusion rats via regulating the balance of Treg / γδ T cells
Brain Res. 2023 Jan 6:148233. doi: 10.1016/j.brainres.2023.148233. Online ahead of print.ABSTRACTElectro-acupuncture (EA) has an anti-inflammatory role in ischemic stroke, but whether the protective effect of EA involves the regulation of the intestine barrier and Treg/ γδ T cells is unclear. Cerebral ischemia-reperfusion (I/R) injury was induced by middle cerebral artery occlusion(MCAO) for 2 hours followed by reperfusion for 24 hours. The rats have treated with EA at the "Baihui" acupoint(GV20). Triphenyl tetrazolium chloride (TTC) staining and Longa neurologic score were performed to evaluate the outcomes after ischem...
Source: Cell Research - January 9, 2023 Category: Cytology Authors: Ya-Ling Wang Ling-Ling Meng Yong-Lin Chen Ling OuYang Bu-Fan Wu Rou Peng Sheng-Feng Lu Qing Liu Tao Zhang Xiao-Xiao Li Xin-Yue Jing Bin Xu Shu-Ping Fu Source Type: research

Upregulation of NOX2 and NOX4 Mediated by TGF- β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury
Conclusions: Our studies demonstrated that TGF- β signaling activation is involved in the regulation of NOX2/NOX4 expression and exacerbates cerebral I/R injury.Cell Physiol Biochem 2018;46:2103 –2113
Source: Cellular Physiology and Biochemistry - May 3, 2018 Category: Cytology Source Type: research

ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy
AbstractAcute ischemic stroke is a devastating disease with very limited therapeutics. Growing appreciation of dysregulated autophagy contributes to the progression of brain ischemic injury, making it to be an appealing intervention target. In terms of its well-characterized consequences, the signal molecules required for autophagy activation are rather poorly defined. Here, we found the induction of chloride channel-3 (ClC-3) directly activated autophagy, which played an important role in limiting cerebral ischemia/reperfusion (I/R) injury. Further mechanism exploration discovered that the up-regulation of ClC-3 was criti...
Source: Human Cell - August 8, 2020 Category: Cytology Source Type: research

Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
In conclusion, SAL reduces the inflammatory response and oxidative stress in a concentration-dependent manner, and protects against cerebral I/R injury by modulating TSC2-induced autophagy. These findings suggest SAL may prove to be a potential therapeutic agent for ischemic stroke.PMID:36374318 | DOI:10.1007/s00221-022-06493-6
Source: Cell Research - November 14, 2022 Category: Cytology Authors: Chunli Li Jiejun Chi Hongyan Dai Ming Liang Yangyang Wang Songxin Tian Huiyan Zhu Hai Xu Source Type: research