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Condition: Ischemic Stroke
Nutrition: Antidoxidants
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Total 671 results found since Jan 2013.
Antioxidant and Anti-apoptotic Effects of Cannabidiol in Model of Ischemic Stroke in Rats
Brain Res Bull. 2022 Jan 11:S0361-9230(22)00004-1. doi: 10.1016/j.brainresbull.2022.01.001. Online ahead of print.ABSTRACTOne of the main non-psychoactive phytocannabinoids of cannabis is cannabidiol (CBD), which has attracted much attention for its neuroprotective roles. The present study was designed to assess whether pretreatment of CBD can attenuate two of the destructive processes of cerebral ischemia, including oxidative stress and cell death. The male rats were randomly divided into 6 main groups (control, MCAO, vehicle, and CBD-treated groups). Using stereotaxic surgery, a cannula was inserted into the right latera...
Source: Brain Research Bulletin - January 15, 2022 Category: Neurology Authors: Sepideh Khaksar Mohammadreza Bigdeli Arash Samiee Zahra Shirazi-Zand Source Type: research
Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats
Brain Res Bull. 2022 Jan 12;180:118-130. doi: 10.1016/j.brainresbull.2022.01.001. Online ahead of print.ABSTRACTOne of the main non-psychoactive phytocannabinoids of cannabis is cannabidiol (CBD), which has attracted much attention for its neuroprotective roles. The present study was designed to assess whether pretreatment of CBD can attenuate two of the destructive processes of cerebral ischemia, including oxidative stress and cell death. The male rats were randomly divided into 6 main groups (control, MCAO, vehicle, and CBD-treated groups). Using stereotaxic surgery, a cannula was inserted into the right lateral ventricl...
Source: Brain Research Bulletin - January 15, 2022 Category: Neurology Authors: Sepideh Khaksar Mohammadreza Bigdeli Arash Samiee Zahra Shirazi-Zand Source Type: research
Astrocytic glycogen mobilization participates in salvianolic acid B-mediated neuroprotection against reperfusion injury after ischemic stroke
Exp Neurol. 2021 Dec 30;349:113966. doi: 10.1016/j.expneurol.2021.113966. Online ahead of print.ABSTRACTAstrocytic glycogen serves as an important glucose reserve, and its degradation provides extra support for neighboring neurons during energy deficiency. Salvianolic acid B (SAB) exerts a neuroprotective effect on reperfusion insult after cerebrovascular occlusion, but the effect of SAB on astrocytic glycogen and its relationship with neuroprotection are not completely understood. Here, we knocked down astrocyte-specific glycogen phosphorylase (GP, the rate-limiting enzyme in glycogenolysis) in vitro and in vivo and inves...
Source: Experimental Neurology - January 2, 2022 Category: Neurology Authors: Haiyun Guo Zhen Zhang Tingting Gu Doutong Yu Yanru Shi Zejun Gao Zhongheng Wang Wenming Liu Ze Fan Wugang Hou Huaning Wang Yanhui Cai Source Type: research
Neuroprotective effects of an < em > in vitro < /em > BBB permeable phenoxythiophene sulfonamide small molecule in glutamate-induced oxidative injury
Exp Ther Med. 2022 Jan;23(1):79. doi: 10.3892/etm.2021.11002. Epub 2021 Nov 25.ABSTRACTReactive oxygen species (ROS) play a central role in oxidative stress-associated neuronal cell death during ischemia. Further investigation into the inhibition of excessive ROS generation post-stroke is urgently required for the treatment of ischemic stroke. In the present study, the neuroprotective properties of the blood-brain barrier (BBB) penetrant B355227 were investigated. B355227 is a chemical analogue of B355252, and the role of the phenoxythiophene sulfonamide compound B355227 was further investigated in a glutamate-induced oxid...
Source: Experimental and Therapeutic Medicine - December 23, 2021 Category: General Medicine Authors: Smritee Pokharel Nailya S Gliyazova Srinivasa R Dandepally Alfred L Williams Gordon C Ibeanu Source Type: research
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
