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Predictors of failure of early neurological improvement in early time window following endovascular thrombectomy: a multi-center study
ConclusionDiabetes mellitus history, pre-stroke mRS, longer last known well-to-puncture time, lack of modified thrombolysis in cerebral infarction = 3, and the number of mechanical thrombectomy passes are the predictors of FENI. Future large-scale studies are required to validate these findings.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research

Sex-dependent association analysis between serum uric acid and spontaneous hemorrhagic transformation in patients with ischemic stroke
ConclusionsHigher serum UA was independently associated with a higher occurrence of spontaneous HT in male patients who were admitted within 24 h after the stroke onset without receiving reperfusion therapy.
Source: Frontiers in Neurology - March 3, 2023 Category: Neurology Source Type: research

Visualization of both proximal M2-MCA segments in patients (the Tilted-V Sign) with acute M1-MCA occlusion stroke is associated with better procedural and prognostic outcomes
ConclusionTilted-V Sign, an easily identifiable radiological marker, is associated with fewer recanalization attempts, better functional outcomes, and reduced mortality.
Source: Frontiers in Neurology - December 13, 2022 Category: Neurology Source Type: research

Biomarker of early neurological deterioration in minor stroke and proximal large vessel occlusion: A pilot study
ConclusionEND in minor stroke with LVO was distinguishable from those without END following the determination of pNFL in the blood samples within 24 h of onset. The pNFL is a promising biomarker of END in minor stroke with LVO.Clinical trial registrationChiCTR1800020330.
Source: Frontiers in Neurology - October 25, 2022 Category: Neurology Source Type: research

Clinical characteristics and outcomes of ischemic stroke patients during Ramadan vs. non-Ramadan months: Is there a difference?
ConclusionBased on our results, there was no difference, in general, between patients with IS during Ramadan and non-Ramadan months. However, IS patients had higher NIHSS scores at discharge and more ICU admissions during Ramadan. Last, we suggest future studies with larger sample sizes, longer duration, and including all types of strokes.
Source: Frontiers in Neurology - July 22, 2022 Category: Neurology Source Type: research

Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis
ConclusionEarly cerebral hemorrhage (ECHO) is a potential prognostic marker for clinicians confronted with decision-making in patients who are critically ill with community-acquired bacterial meningitis.
Source: Frontiers in Neurology - June 16, 2022 Category: Neurology Source Type: research

Endovascular Thrombectomy Eligibility in the 0-24-Hour Time Window at a Large Academic Center in India
Conclusion: In our study, the proportion of AIS eligible for endovascular thrombectomy was comparable to the developed world. These data predict a large potential for the late-window EVT in India.
Source: Neurology India - May 3, 2022 Category: Neurology Authors: Deepti Vibha Shubham Misra Shashvat M Desai Kameshwar Prasad Achal K Srivastava Awadh K Pandit Ashutosh P Jadhav Source Type: research

Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy
ConclusionOur study provides evidence that in patients with AIS due to LVO treated with MT, the burden of SVD assessed by pre-treatment MRI is associated with poorer recruitment of leptomeningeal collaterals.
Source: Journal of Neurology - April 6, 2022 Category: Neurology Source Type: research

Early Neurological Improvement Predicts Clinical Outcome After Thrombectomy for Distal Medium Vessel Occlusions
ConclusionENI at day 1 following MT for DMVO stroke is a strong independent predictor of good to excellent 3-month clinical outcome.
Source: Frontiers in Neurology - March 7, 2022 Category: Neurology Source Type: research

Acute telestroke evaluations during the COVID-19 pandemic
This study is a retrospective database review of all telestroke requests at one academic vascular neurology center telestroke network with seven remote sites in the USA between March 15 and April 30, 2020. Data were compared with historical cohort spanning same time frame in 2019 using parametric or nonparametric methods as appropriate. Among telestroke requests, characteristics of age, gender, race/ethnicity, National Institutes of Health Stroke Scale (NIHSS), primary diagnosis of AIS or transient ischemic attack (TIA), and number of patients receiving intravenous alteplase (IV-rtPA) and endovascular therapy (ET) were rec...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Aspiration Pneumonia in Adults Hospitalized With Stroke at a Large Academic Hospital in Zambia
Discussion PSAP is common and life threatening in Zambia, especially among older participants with severe stroke presentations. PSAP was associated with significantly increased mortality independent of initial stroke severity, suggesting that interventions to mitigate PSAP may improve stroke outcomes in Zambia and other resource-limited settings.
Source: Neurology Clinical Practice - December 13, 2021 Category: Neurology Authors: Prust, M. L., Nutakki, A., Habanyama, G., Chishimba, L., Chomba, M., Mataa, M., Yumbe, K., Zimba, S., Gottesman, R. F., Bahouth, M. N., Saylor, D. R. Tags: All Cerebrovascular disease/Stroke, All global neurology Research Source Type: research

Predictive Factors for the Need of Tracheostomy in Patients With Large Vessel Occlusion Stroke Being Treated With Mechanical Thrombectomy
Conclusions: Patients with LVOS undergoing MT are at high risk to require TS if extubation after the intervention fails, DH is needed, and severe infectious complications occur in the acute phase after ischemic stroke. These factors are likely to be useful for the indication and timing of TS to reduce overall sedation and shorten ICU length of stay.
Source: Frontiers in Neurology - November 26, 2021 Category: Neurology Source Type: research

Multi-Center Randomized Phase II Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies (TRICS-9): Study Design and Protocol
Conclusion: RIC in combination with recanalization therapies appears to add no clinical benefit to patients, but whether it is beneficial to those that are not candidates for recanalization therapies is still to be demonstrated. TRICS-9 has been developed to elucidate this issue.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT04400981.
Source: Frontiers in Neurology - November 3, 2021 Category: Neurology Source Type: research

Stroke Seasonality and Weather Association in a Middle East Country: A Single Tertiary Center Experience
Conclusions: In Riyadh, Saudi Arabia, our study found no impact of weather or seasonal variations on stroke incidence, hospital course, or outcomes. However, our findings warrant further research in different country regions.
Source: Frontiers in Neurology - October 18, 2021 Category: Neurology Source Type: research

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