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Condition: Ischemic Stroke
Education: Study
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Total 367 results found since Jan 2013.

Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news

Device use trends in neuroendovascular procedures in the United States from 2015 to 2020
CONCLUSION: Our study demonstrates an increase in the use of flow-diverting stents, nondiverting stents, carotid stents, and reperfusion devices for acute ischemic stroke intervention between 2015 and 2020. Coil use for aneurysmal treatment has declined.PMID:37642975 | DOI:10.1177/15910199231196329
Source: Interventional Neuroradiology - August 29, 2023 Category: Radiology Authors: Arjun Rohit Adapa Fazeel M Siddiqui Aditya S Pandey Source Type: research

Comparative outcomes associated with rivaroxaban versus warfarin use in elderly patients with atrial fibrillation or acute venous thromboembolism managed in the United States: a systematic review of observational studies
CONCLUSIONS: This systematic review supports findings from subgroup analyses of randomized controlled trials that, compared with warfarin, rivaroxaban is associated with generally neutral or positive effects on thrombosis and a mixed picture on bleeding outcomes in older adults with either NVAF or VTE treated in the United States.PMID:37584187 | DOI:10.1080/03007995.2023.2247988
Source: Current Medical Research and Opinion - August 16, 2023 Category: Research Authors: William L Baker Matthew S Roberts Youssef Bessada Kimberly S Caroti Veronica Ashton Brahim K Bookhart Craig I Coleman Source Type: research

Plasma Trimethylamine- < em > N < /em > -Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis
Conclusions Plasma TMAO levels are associated with incident ischemic stroke in a diverse population. Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00005133.PMID:37581385 | DOI:10.1161/JAHA.122.029230
Source: Atherosclerosis - August 15, 2023 Category: Cardiology Authors: Rozenn N Lemaitre Paul N Jensen Zeneng Wang Amanda M Fretts Colleen M Sitlani Ina Nemet Nona Sotoodehnia Marcia C de Oliveira Otto Weifei Zhu Matt Budoff W T Longstreth Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research

Effect of Radiographic Contrast Media Shortage on Stroke Evaluation in the United States ADULT BRAIN
CONCLUSIONS: Our analysis reported changes in the use of CTA and CTP in patients with acute ischemic stroke during the contrast media shortage. Further research needs to identify effective strategies to reduce the reliance on contrast media–based studies such as CTA and CTP without compromising patient outcomes.
Source: American Journal of Neuroradiology - August 9, 2023 Category: Radiology Authors: Qureshi, A. I., Grintal, A., DeGaetano, A. C., Goren, M., Lodhi, A., Golan, D., Hassan, A. E. Tags: ADULT BRAIN Source Type: research

E-111 Repeat thrombectomy after large vessel occlusion stroke: incidence, clinical and technical outcomes
ConclusionsRepeat EVT for patients with re-occlusion within 30 days of thrombectomy is associated with favorable improvement in NIHSS, similar functional outcomes to patients undergoing single EVT, but has significantly higher risk of hemorrhagic conversion.Disclosures Y. Zohdy: None. H. Saad: None. B. Howard: None. C. Cawley: None. A. Pabaney: None. T. Garzon-Muvdi: None. I. Maier: None. A. Spiotta: None. P. Jabbour: None. S. Wolfe: None. A. Rai: None. J. Kim: None. J. Mascitelli: None. R. Starke: None. A. Shaban: None. S. Yoshimura: None. R. De Leacy: None. P. Kan: None. I. Fragata: None. A. Polifka: None. A. Arthur: Non...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Zohdy, Y., Saad, H., Howard, B., Cawley, C., Pabaney, A., Garzon-Muvdi, T., Maier, I., Spiotta, A., Jabbour, P., Wolfe, S., Rai, A., Kim, J., Mascitelli, J., Starke, R., Shaban, A., Yoshimura, S., De Leacy, R., Kan, P., Fragata, I., Polifka, A., Arthur, A Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-152 Cone-beam CT angiogram acquisition in the angiography suite for LVO detection in acute ischemic stroke
ConclusionDTAS triage workflow with cone-beam head CT and CTA image acquisition in the angiography suite may be a next step to further optimize LVO stroke pathways by bypassing conventional CT/MR. This new workflow has the potential to further decrease door-to-needle times and thereby may improve patient outcome.Disclosures A. Kuhn: None. J. Singh: None. M. Garcia: None. S. Sarid: None. M. Gounis: 1; C; National Institutes of Health (NIH), the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Arsenal Medical, Axovant, Balt, Cerenovus, Ceretrieve, CereVasc LLC, Cook Medical, Gal. 2; C; fee-per-h...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Garcia, M., Sarid, S., Gounis, M., Anagnostakou, V., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

O-001 Trends in endovascular mechanical thrombectomy for acute ischemic stroke: a regional comparison analysis using United States national inpatient sample data
ConclusionsThere remain significant regional differences in the outcomes of EVT for AIS. More analysis is required to determine what is driving these differences. More work is needed to ensure optimal and equitable patient outcomes.Abstract O-001 Table 1 Characteristic (p value) East North Central East South Central Middle Atlantic Mountain New England Pacific South Atlantic West North Central West South Central Age in Years Mean (±SD)(p<0.001) 68.69 ± 14.43 67.04 ± 14.85 70.09 ± 14.39 68.72 ± 14.53 70.27 ± 14.92 70.26 ± 14.51 68.81 ± 14.29 69.21 ± 14.51 67...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Brake, A., Fry, L., LeBeau, G., Heskett, C., Lei, C., Alkiswani, A., Le, K., De-Stefano, F., Peterson, J., Ebersole, K. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

E-185 Study design and rationale of THUNDER: an acute ischemic stroke study with the penumbra system including thunderbolt aspiration tubing
ConclusionWe report the design of THUNDER—a multicenter prospective study that examines the use of a novel modulated aspiration thrombectomy system in patients with AIS secondary to LVO.Disclosures D. Fiorella: 1; C; Cerenovus, Medtronic, Siemens, Stryker, Microvention, Penumbra. 2; C; Balt, Marblehead, Medtronic, Stryker, Microvention, Penumbra, Cerenovus. K. Woodward: 2; C; Coviden. E. Levy: None. C. Matouk: 2; C; Silk Road Medical, Penumbra, MicroVention-TERUMO, Medtronic, Stryker. 3; C; Silk Road Medical, Penumbra. I. Kaminsky: 3; C; Penumbra. K. Reuland: None. M. Stiefel: None. A. Kansagra: 1; C; Penumbra. 2; C;...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Fiorella, D., Woodward, K., Levy, E., Matouk, C., Kaminsky, I., Reuland, K., Stiefel, M., Kansagra, A., Frei, D. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

The incidence of medium vessel occlusions: a population-based study
ConclusionAs the only stroke center in Olmsted County, we have been able to estimate the incidence of ischemic stroke due to MeVO. While the incidence of MeVOs is less than both large and small vessel occlusions, they still represent a significant proportion of strokes with significant morbidity and mortality that would benefit from further studies in both acute intervention and prevention.
Source: Frontiers in Neurology - July 27, 2023 Category: Neurology Source Type: research

Roche enters partnership with Alnylam to co-develop and co-commercialise RNAi therapeutic zilebesiran to treat hypertension in patients with high cardiovascular risk
Partnership combines Roche ’s proven track record of successfully developing and launching innovative medicines worldwide withAlnylam ’s leadership in RNAi therapeuticsZilebesiran, a Phase 2 RNAi therapeutic, has best-in-disease potential for patients with hypertension at high risk of cardiovascular morbidity and mortality, by robustly and durably lowering blood pressureHypertension, the leading cause of cardiovascular disease, affects more than 1.2 billion adults worldwide. While several therapies exist, a significant unmet need, especially for high risk patients, remains.1Basel, 24 July 2023 - Roche (SIX: RO, ROG; OT...
Source: Roche Media News - July 24, 2023 Category: Pharmaceuticals Source Type: news