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Condition: Glaucoma

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Total 129 results found since Jan 2013.

Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell-cell interactions in the pathophysiology of neurological disease
Cell Mol Life Sci. 2022 Mar 4;79(3):172. doi: 10.1007/s00018-022-04185-6.ABSTRACTNeuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, maturation and synaptic refinement. The proteinase inhibitor may function both independently and through tPA-dependent mechanisms. Herein, we discuss the recent evidence regarding the role of neuroserpin in healthy and diseased conditions and highlight the participation of the serpin in various c...
Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2022 Category: Cytology Authors: Angela Godinez Rashi Rajput Nitin Chitranshi Veer Gupta Devaraj Basavarajappa Samridhi Sharma Yuyi You Kanishka Pushpitha Kunal Dhiman Mehdi Mirzaei Stuart Graham Vivek Gupta Source Type: research

Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial
Introduction Sleep-time blood pressure correlates more strongly with adverse cardiovascular events than does daytime blood pressure. The BedMed trial evaluates whether bedtime antihypertensive administration, as compared with conventional morning use, reduces major adverse cardiovascular events. Methods and analysis Design Prospective randomised, open-label, blinded end-point trial. Participants Hypertensive primary care patients using blood pressure lowering medication and free from glaucoma. Setting Community primary care providers in 5 Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba and Ontario) a...
Source: BMJ Open - February 24, 2022 Category: General Medicine Authors: Garrison, S. R., Kolber, M. R., Allan, G. M., Bakal, J., Green, L., Singer, A., Trueman, D. R., McAlister, F. A., Padwal, R. S., Hill, M. D., Manns, B., McGrail, K., O'Neill, B., Greiver, M., Froentjes, L. S., Manca, D. P., Mangin, D., Wong, S. T., MacLea Tags: Open access, Cardiovascular medicine Source Type: research

Ocular Manifestations, Visual Field Pattern, and Visual Field Test Performance in Traumatic Brain Injury and Stroke
CONCLUSION: Various ocular manifestations were found, and a considerable proportion of patients were experiencing VF defects and showed unreliable VF test performance. Our findings suggest that accurate evaluation and rehabilitation of visual function should be a matter of greater concern and emphasis in the management of TBI and stroke patients, besides systemic diseases.PMID:35036002 | PMC:PMC8759901 | DOI:10.1155/2022/1703806
Source: Journal of Ophthalmology - January 17, 2022 Category: Opthalmology Authors: Yun Jeong Lee Seung Chan Lee Seo Young Wy Hoo Young Lee Hyang Lim Lee Woo Hyung Lee Byung-Mo Oh Jin Wook Jeoung Source Type: research

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement
AbstractRetinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated . RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several deve...
Source: Molecular Neurobiology - January 11, 2022 Category: Neurology Source Type: research

Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans
CONCLUSIONS: When interpreting OCTA images in a clinical setting, it is important to consider the effects ocular and systemic characteristics may have on the macular microcirculation.PMID:34740885 | DOI:10.1136/bjophthalmol-2021-319675
Source: The British Journal of Ophthalmology - November 6, 2021 Category: Opthalmology Authors: Grace M Richter Jae Chang Lee Nasir Khan Alexander Vorperian Brennan Hand Bruce Burkemper Xiao Zhou Zhongdi Chu Ruikang Wang Rohit Varma Amir H Kashani Source Type: research

Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Source: The British Journal of Ophthalmology - September 14, 2021 Category: Opthalmology Authors: Xianwen Shang Zhuoting Zhu Yu Huang Xueli Zhang Wei Wang Danli Shi Yu Jiang Xiaohong Yang Mingguang He Source Type: research