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Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
ConclusionsSARS-CoV-2 can lead to neurological complications, such as cerebrovascular manifestations, motor movement complications, and cognitive decline. COVID-19 infection can result in cerebrovascular symptoms and diseases, such as strokes and thrombosis. The virus can affect the neural system, disrupt cognitive function and cause neurological disorders. To combat the epidemic, it is crucial to repurpose drugs currently in use quickly and develop novel therapeutics.
Source: European Journal of Medical Research - August 30, 2023 Category: Research Source Type: research

Diagnosis of Coronary Artery Disease based on Machine Learning algorithms Support Vector Machine, Artificial Neural Network, and Random Forest
CONCLUSION: In this study, it was shown that machine learning algorithms can be used with high accuracy to detect CAD. Thus, it allows physicians to perform timely preventive treatment in patients with CAD.PMID:37057235 | PMC:PMC10086656 | DOI:10.4103/abr.abr_383_21
Source: Biomed Res - April 14, 2023 Category: Research Authors: Saeed Saeedbakhsh Mohammad Sattari Maryam Mohammadi Jamshid Najafian Farzaneh Mohammadi Source Type: research

Clinical significance of obstructive sleep apnea in patients with acute coronary syndrome with or without prior stroke: a prospective cohort study
ConclusionsAmong ACS patients, the presence of OSA was associated with an increased risk of cardiovascular events in patients with prior stroke. Further trials exploring the efficacy of OSA treatment in high-risk patients with ACS and prior stroke are warranted.Trial registration Clinicaltrials.gov identifier NCT03362385.
Source: European Journal of Medical Research - March 1, 2023 Category: Research Source Type: research

Methods of Determining Homeostatic Perturbations
Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level.   Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular activity; for instance resting states or active states (e.g., intensive physical or mental activity or intensive physical or mental stimulation).  Deviations or perturbations from biological homeostasis, even at the cellular level, can be caused by pathological conditions such as diseases within the o...
Source: NIH OTT Licensing Opportunities - January 24, 2023 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired NICHD Source Type: research

Identification of salivary microRNA profiles in male mouse model of chronic sleep disorder
Stress. 2023 Jan;26(1):21-28. doi: 10.1080/10253890.2022.2156783.ABSTRACTChronic sleep disorders (CSD) comprise a potential risk factor for metabolic and cardiovascular diseases, obesity and stroke. Thus, the identification of biomarkers for CSD is an important step in the early prevention of metabolic dysfunctions induced by sleep dysfunction. Diagnostic saliva samples can be easily and noninvasively collected. Thus, we aimed to identify whole microRNA (miRNA) profiles of saliva in control and psychophysiologically stressed CSD mouse models and compare them at Zeitgeber time (ZT) 0 (lights on) and ZT12 (lights off). The f...
Source: Stress - December 15, 2022 Category: Research Authors: Yuta Yoshida Yuhei Yajima Yuri Fujikura Haotong Zhuang Sayaka Higo-Yamamoto Atsushi Toyoda Katsutaka Oishi Source Type: research

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