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Hyperdopaminergism in Lenticulostriate Stroke-Induced Restless Legs Syndrome: A Neuro Imaging Study (P7.303)
CONCLUSIONS: A systematic study of small lesions associated with RLS may contribute to understanding the pathophysiological mechanisms underlying this condition. In this regard, the body of the caudate nucleus might be an important structure. The isotopic results reinforce the hypothesis of an increased dopaminergic tone in the striatum as part of RLS pathophysiology. Thus, the efficacy with low doses of dopaminergic agonists in RLS could be explained by stimulation of inhibitory D2-like autoreceptors.Disclosure: Dr. Ruppert has nothing to disclose. Dr. Bataillard has nothing to disclose. Dr. Namer has nothing to disclose....
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ruppert, E., Bataillard, M., Namer, I., Tatu, L., Wolff, V., Velizarova, R., Hacquard, A., Killic-Huck, U., Bourgin, P. Tags: Sleep: Restless Legs and REM Disorders Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Near infrared spectroscopy - investigations in neurovascular diseases.
This study showed increased LFOs amplitude only in FHM patients with co-existing common type of migraine, but not in patients with pure FHM phenotype. This suggests that the sensitivity to NO resides within the common migraine phenotypes rather than the FHM phenotype. Stimulation of the sphenopalatine ganglion (SPG) may lead to parasympathetic outflow and cause pain in cluster headache (CH). The fifth study therefore investigated pain and autonomic symptoms in relation to high or low SPG frequency stimulation in chronic CH patients. Cortical changes in oxygenated hemoglobin (HbO) were also recorded with NIRS and showed a m...
Source: Danish Medical Journal - December 12, 2015 Category: Journals (General) Tags: Dan Med J Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research