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Risk of new ‐onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study
ConclusionThe findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.
Source: International Forum of Allergy and Rhinology - February 22, 2023 Category: Allergy & Immunology Authors: Annemarie G. Hirsch, Brian S. Schwartz, Cara Nordberg, Bruce K. Tan, Robert P. Schleimer, Robert C. Kern, Anju T. Peters, Karen Bandeen ‐Roche, Ashton E. Lehmann Tags: ORIGINAL ARTICLE Source Type: research

Risk of new onset and prevalent disease in chronic rhinosinusitis: a prospective cohort study
Conclusion: The findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - February 9, 2023 Category: Allergy & Immunology Authors: Annemarie G. Hirsch, Brian S. Schwartz, Cara Nordberg, Bruce K. Tan, Robert P. Schleimer, Robert C. Kern, Anju T. Peters, Karen Bandeen ‐Roche, Ashton E. Lehmann Tags: ORIGINAL ARTICLE Source Type: research

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania
Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 Address correspondence to B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7041, Baltimore, MD 21205 USA. Teleph...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis
Background: Chronic rhinosinusitis (CRS) is a prevalent condition with underexplored risk factors.Objectives: We sought to determine CRS incidence and evaluate associations with a range of premorbid medical conditions for chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP) using real-world clinical practice data.Methods: Electronic health records data from 446,480 Geisinger Clinic primary care patients were used for a retrospective longitudinal cohort study for data from 2001-2010. By using logistic regression, newly diagnosed CRS cases between 2007 and 2009 were compa...
Source: Journal of Allergy and Clinical Immunology - March 29, 2013 Category: Allergy & Immunology Authors: Bruce K. Tan, Rakesh K. Chandra, Jonathan Pollak, Atsushi Kato, David B. Conley, Anju T. Peters, Leslie C. Grammer, Pedro C. Avila, Robert C. Kern, Walter F. Stewart, Robert P. Schleimer, Brian S. Schwartz Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research