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Vaccination: Hepatitis Vaccine
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Total 293 results found since Jan 2013.
Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice
Vaccine. 2023 Jun 28:S0264-410X(23)00783-1. doi: 10.1016/j.vaccine.2023.06.080. Online ahead of print.ABSTRACTAs the COVID-19 pandemic transitions into endemicity, seasonal boosters are a plausible reality across the globe. We hypothesize that intranasal vaccines can provide better protection against asymptomatic infections and more transmissible variants of SARS-CoV-2. To formulate a protective intranasal vaccine, we utilized a VLP-based platform. Hepatitis B surface antigen-based virus like particles (VLP) linked with receptor binding domain (RBD) antigen were paired with the TLR4-based agonist adjuvant, BECC 470. K18-hA...
Source: Vaccine - July 5, 2023 Category: Allergy & Immunology Authors: Katherine S Lee Nathaniel A Rader Olivia A Miller-Stump Melissa Cooper Ting Y Wong Md Shahrier Amin Mariette Barbier Justin R Bevere Robert K Ernst F Heath Damron Source Type: research
Combination Therapy for the Treatment of Shingles with an Immunostimulatory Vaccine Virus and Acyclovir
Pharmaceuticals (Basel). 2023 Feb 1;16(2):226. doi: 10.3390/ph16020226.ABSTRACTPractically the entire global population is infected by herpesviruses that establish lifelong latency and can be reactivated. Alpha-herpesviruses, herpes simplex viruses 1 and 2 (HSV-1/HSV-2) and varicella zoster virus (VZV), establish latency in sensory neurons and then reactivate to infect epithelial cells in the mucosa or skin, resulting in a vesicular rash. Licensed antivirals inhibit virus replication, but do not affect latency. On reactivation, VZV causes herpes zoster, also known as shingles. The 76-year-old first author of this paper pub...
Source: Herpes - June 1, 2023 Category: Infectious Diseases Authors: Tibor Bakacs Volker Sandig Imre Kovesdi Source Type: research
Advances in intranasal vaccine delivery: A promising non-invasive route of immunization
Vaccine. 2023 May 11:S0264-410X(23)00529-7. doi: 10.1016/j.vaccine.2023.05.011. Online ahead of print.ABSTRACTThe importance of vaccination has been proven particularly significant the last three years, as it is revealed to be the most efficient weapon for the prevention of several infections including SARS-COV-2. Parenteral vaccination is the most applicable method of immunization, for the prevention of systematic and respiratory infections, or central nervous system disorders, involving T and B cells to a whole-body immune response. However, the mucosal vaccines, such as nasal vaccines, can additionally activate the immu...
Source: Vaccine - May 13, 2023 Category: Allergy & Immunology Authors: Eleni Kehagia Paraskevi Papakyriakopoulou Georgia Valsami Source Type: research
Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis
In conclusion, molecular mimicry may be a missing causality of autoimmune hepatitis. Molecular mimics of key immune dominant epitopes of disease-specific antigens must be sought in diverse environmental antigens. The ubiquity of molecular mimicry compels rigorous assessments of peptide mimics for immunogenicity and pathogenicity in experimental models. Molecular mimicry may complement epigenetic modifications as causative mechanisms of autoimmune hepatitis.
Source: Digestive Diseases and Sciences - May 9, 2023 Category: Gastroenterology Source Type: research
Autoimmune liver diseases and SARS-CoV-2
World J Gastroenterol. 2023 Mar 28;29(12):1838-1851. doi: 10.3748/wjg.v29.i12.1838.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), can trigger autoimmunity in genetically predisposed individuals through hyperstimulation of immune response and molecular mimicry. Here we summarise the current knowledge about auto-immune liver diseases (AILDs) and SARS-CoV-2, focusing on: (1) The risk of SARS-CoV-2 infection and the course of COVID-19 in patients affected by AILDs; (2) the role of SARS-CoV-2 in inducing liver damage and triggering AILDs; and (3) the ability of...
Source: World Journal of Gastroenterology : WJG - April 10, 2023 Category: Gastroenterology Authors: Costantino Sgamato Alba Rocco Debora Compare Stefano Minieri Stefano Andrea Marchitto Simone Maurea Gerardo Nardone Source Type: research
