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Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research

Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations
CONCLUSION: In conclusion, there are many anti-arthritic herbal and synthetic medicine available in the market that are currently used in the treatment of RA. However, chronic use of these medications may result in a variety of side effects. Because therapy for RA is frequently necessary for the rest of ones life. The use of natural products may be a better option for RA management. These phytoconstituents, however, have several disadvantages, including limited bioavailability, low stability, and the need for a greater dosage. These problems can be rectified by using nano-technology.PMID:37622715 | DOI:10.2174/1567201821666230825102748
Source: Current Drug Delivery - August 25, 2023 Category: Drugs & Pharmacology Authors: Jyoti Prabha Mohit Kumar Devesh Kumar Shruti Chopra Amit Bhatia Source Type: research

Ethnomedicinal importance of Patuletin in Medicine: Pharmacological Activities and Analytical Aspects
CONCLUSION: It may be concluded that patuletin with its diverse biological activities and readily available analytical methods, holds the potential to be translated into a new drug entity.PMID:37584350 | DOI:10.2174/1871530323666230816141740
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 16, 2023 Category: Endocrinology Authors: Dinesh Kumar Patel Gireesh Kumar Singh Gulam Mohammed Husain Satyendra K Prasad Source Type: research

Dietary, Herbal and Nutritional Interventions for Managing Rheumatoid Arthritis: A Review
Curr Pharm Biotechnol. 2023 Aug 7. doi: 10.2174/1389201024666230807155529. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a systemic, inflammatory disease that affects joints and leads to progressive cartilage and bone deterioration. The susceptibility to RA is determined by genetic and environmental factors. Recently, many efforts have been undertaken to develop natural compounds capable of reducing the symptoms of RA to avoid the negative effects of the current anti-inflammatory drugs. Interestingly, substantial data has revealed that nutritional, and herbal supplements may be effective adjuvants in reducing ...
Source: Current Pharmaceutical Biotechnology - August 8, 2023 Category: Biotechnology Authors: Aanchal Verma Nandini Dubey Anant Agrawal Ahsas Goyal Source Type: research

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