Filtered By:
Specialty: Drugs & Pharmacology
Condition: Diabetes
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 224 results found since Jan 2013.
Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Drugs & Pharmacology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway
This study aims to evaluate underlying mechanisms of ADMA in DCM especially for EndMT under diabetic conditions. A diabetic rat model was induced by streptozotocin (STZ) injection, and human cardiac microvascular endothelial cells (HCMECs) were stimulated with high glucose to induce EndMT. Subsequently, the role of ADMA in EndMT was detected either by exogenous ADMA or by over-expressing dimethylarginine dimethylaminohydrolase 1 (DDAH1, degradation enzyme for ADMA) before high glucose stimulation. Furthermore, the relationships among forkhead box protein O1 (FoxO1), DDAH1 and ADMA were evaluated by FoxO1 over-expression or...
Source: European Journal of Pharmacology - April 28, 2023 Category: Drugs & Pharmacology Authors: Meiting Wu Ting Li Ge Li Bingxuan Niu Tian Wu Li Yan Shiming Wang Shuangyi He Chuyi Huang Weiqiang Tong Niansheng Li Junlin Jiang Source Type: research
Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Drugs & Pharmacology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research
Cell surface GRP78 regulates TGF β1-mediated profibrotic responses via TSP1 in diabetic kidney disease
Discussion: These data support an important role for csGRP78 in regulating HG-induced TSP1 transcriptional induction via PI3K/Akt signaling. Functionally, this enables TGFβ1 activation in response to HG, with consequent increase in ECM proteins. Means of inhibiting csGRP78 signaling represent a novel approach to preventing fibrosis in DKD.
Source: Frontiers in Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
Regulation of NcRNA-protein binding in diabetic foot
In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU.PMID:36753956 | DOI:10.1016/j.biopha.2023.114361
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 8, 2023 Category: Drugs & Pharmacology Authors: Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu Source Type: research
