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Specialty: Molecular Biology
Condition: Diabetes
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Total 188 results found since Jan 2013.
Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
Exp Mol Med. 2022 Aug 2. doi: 10.1038/s12276-022-00810-3. Online ahead of print.ABSTRACTSrc family kinases (SFKs) have been implicated in the pathogenesis of kidney fibrosis. However, the specific mechanism by which SFKs contribute to the progression of diabetic kidney disease (DKD) remains unclear. Our preliminary transcriptome analysis suggested that SFK expression was increased in diabetic kidneys and that the expression of Fyn (a member of the SFKs), along with genes related to unfolded protein responses from the endoplasmic reticulum (ER) stress signaling pathway, was upregulated in the tubules of human diabetic kidne...
Source: Molecular Medicine - August 2, 2022 Category: Molecular Biology Authors: Debra Dorotea Songling Jiang Eun Seon Pak Jung Beom Son Hwan Geun Choi Sung-Min Ahn Hunjoo Ha Source Type: research
H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes
CONCLUSIONS: Our results suggest a critical role for the lncRNA H19-HDAC6 axis in regulating IRS1 levels in the skeletal muscle during diabetes and therefore restoring normal H19 levels might hold a therapeutic potential for the management of aberrant skeletal muscle physiology during insulin resistance and type 2 diabetes.PMID:35842608 | DOI:10.1186/s10020-022-00507-3
Source: Molecular Medicine - July 16, 2022 Category: Molecular Biology Authors: Amit Kumar Malabika Datta Source Type: research
Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress
CONCLUSIONS: Acacetin may antagonize lipotoxicity in pancreatic cells by attenuating the oxidative stress and ER stress.PMID:35780455 | DOI:10.1007/s11033-022-07717-2
Source: Mol Biol Cell - July 3, 2022 Category: Molecular Biology Authors: Ning Wang Qing Gao Jie Shi Chen Yulan Weimeng Ji Xiumei Sheng Rui Zhang Source Type: research
Characterization of the secretome, transcriptome and proteome of human β cell line EndoC-βH1
Mol Cell Proteomics. 2022 Apr 1:100229. doi: 10.1016/j.mcpro.2022.100229. Online ahead of print.ABSTRACTEarly diabetes research is hampered by limited availability, variable quality and instability of human pancreatic islets in culture. Little is known about the human β cell secretome, and recent studies question translatability of rodent β cell secretory profiles. Here, we verify representativeness of EndoC-βH1, one of the most widely used human β cell lines, as a translational human β cell model based on omics and characterize the EndoC-βH1 secretome. We profiled EndoC-βH1 cells using RNA-seq, Data Independent Acq...
Source: Molecular and Cellular Proteomics : MCP - April 4, 2022 Category: Molecular Biology Authors: Maria Ryaboshapkina Kevin Saitoski Ghaith M Hamza Andrew F Jarnuczak S éverine Pechberty Claire Berthault Kaushik Sengupta Christina Rye Underwood Shalini Andersson Raphael Scharfmann Source Type: research
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Mol Biol Cell - April 3, 2022 Category: Molecular Biology Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research
Rosmarinic acid downregulates the oxLDL ‑induced interaction between monocytes and endothelial cells, in addition to monocyte diapedesis, under high glucose conditions
Int J Mol Med. 2022 May;49(5):68. doi: 10.3892/ijmm.2022.5125. Epub 2022 Mar 22.ABSTRACTEndothelial dysfunction during diabetes has been previously reported to be at least in part attributed to increased oxidized low‑density lipoprotein (oxLDL) levels mediated by high glucose (HG) levels. Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. In a previous study, it was reported that oxLDL treatment induced nucleotide‑binding domain and leucine‑rich repeat containing family, pyrin domain‑containing 3 infl...
Source: International Journal of Molecular Medicine - March 22, 2022 Category: Molecular Biology Authors: Jean Baptiste Nyandwi Young Shin Ko Hana Jin Seung Pil Yun Sang Won Park Kee Ryeon Kang Hye Jung Kim Source Type: research
