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Total 719 results found since Jan 2013.
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Her work paved the way for blockbuster obesity drugs. Now, she ’s fighting for recognition
When Svetlana Mojsov heard the spring 2021 announcement, she was startled. The Canada Gairdner International Award, a prestigious biomedical research prize, would be bestowed on three scientists for work underpinning the diabetes and obesity drugs that have exploded in popularity in recent years. “I was really upset,” recalls Mojsov, a chemist at Rockefeller University.
The Gairdner award marked the third time in 4 years that the same trio of scientists—Joel Habener at Massachusetts General Hospital (MGH), Daniel Drucker at the University of Toronto, and Jens Juul Holst at the University of Copenhagen—were hon...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research
Current advancements and prospects of enzymatic and non-enzymatic electrochemical glucose sensors
Int J Biol Macromol. 2023 Sep 4:126680. doi: 10.1016/j.ijbiomac.2023.126680. Online ahead of print.ABSTRACTThis review discusses the most current developments and future perspectives in enzymatic and non-enzymatic glucose sensors, which have notably evolved over the preceding quadrennial period. Furthermore, a thorough exploration encompassed the sensor's intricate fabrication processes, the diverse range of materials employed, the underlying principles of detection, and an in-depth assessment of the sensors' efficacy in detecting glucose levels within essential bodily fluids such as human blood serums, urine, saliva, and ...
Source: International Journal of Biological Macromolecules - September 6, 2023 Category: Biochemistry Authors: Muthukumar Govindaraj Ananya Srivastava Magesh Kumar Muthukumaran Pei-Chien Tsai Yuan-Chung Lin Bharathi Kannan Raja Jerome Rajendran Vinoth Kumar Ponnusamy J Arockia Selvi Source Type: research
Unraveling crime scenes strand by strand: the forensic odyssey of Bruce Budowle
Biotechniques. 2023 Aug 25. doi: 10.2144/btn-2023-0069. Online ahead of print.ABSTRACTBruce Budowle speaks to Ashling Cannon, Journal Development Editor for BioTechniques, about advancements & challenges in forensic science. Budowle completed his doctorate in genetics at Virginia Tech (VA, USA) formally known as Virginia Polytechnic Institute and State University. He then went on to complete a postdoctoral fellowship at the University of Alabama at Birmingham (AL, USA) to study genetic risk factors for acute lymphocytic leukemia, diabetes and melanoma. Budowle was early in his career and hadn't spent much time in foren...
Source: BioTechniques - August 25, 2023 Category: Biotechnology Authors: Bruce Budowle Source Type: research
Understanding how and why upskilling programmes for unregulated care providers can support health equity in underserved communities: a realist review protocol
Introduction
Foot ulcers are one of the most devastating complications of diabetes mellitus leading to leg amputations. In Canada, systematically marginalised and racialised populations are more prone to developing foot ulcers and at higher risk of limb amputations. Shortages of regulated healthcare have hindered efforts to provide foot care. Upskilling unregulated care providers (UCPs) to deliver foot screening seems a reasonable solution to reduce limb loss. UCPs can advocate for health equity and deliver appropriate care. There is a need, however, to understand how and why an educational intervention for UCPs providing ...
Source: BMJ Open - August 23, 2023 Category: General Medicine Authors: Hassan, S., Rac, V. E., Hodges, B. D., Leake, P., Cobbing, S., Gray, C. M., Bartley, N., Etherington, A., Abdulwasi, M., Cheung, H.-C. K., Anderson, M., Woods, N. N. Tags: Open access, Diabetes and Endocrinology Source Type: research
Molecules, Vol. 28, Pages 6141: Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review
d Torequl Islam
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various Uncaria species and has a multitude of therapeutic benefits. It is found in foodstuffs such as fish, seafood, meat, poultry, dairy, and some grain products among other things. In addition, it is present in fruits and vegetables including corn, cauliflower, mushrooms, po...
Source: Molecules - August 19, 2023 Category: Chemistry Authors: Md. Shimul Bhuia Polrat Wilairatana Jannatul Ferdous Raihan Chowdhury Mehedi Hasan Bappi Md Anisur Rahman Mohammad S. Mubarak Muhammad Torequl Islam Tags: Review Source Type: research
A Systematic Review of Reviews on The Impact of Exercise Training on Pulse Wave Velocity in Adults
Am J Physiol Heart Circ Physiol. 2023 Aug 18. doi: 10.1152/ajpheart.00249.2023. Online ahead of print.ABSTRACTElevated pulse wave velocity (PWV) determined arterial stiffness is a prominent marker of cardiovascular disease (CVD) risk. Exercise training delays the progression of CVD, but existing reviews on the impact of training on PWV are conflicting. We synthesized the evidence on the effects of exercise training interventions on PWV. We searched Scopus, EMBASE, PubMed, CINAHL, and Academic Search Premier databases for systematic reviews including PWV, and examined the effects of exercise training on PWV. 842 citations w...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 18, 2023 Category: Physiology Authors: Haoxuan Liu Madeline E Shivgulam Beverly D Schwartz Derek S Kimmerly Myles W O'Brien Source Type: research
