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Dupilumab strengthens HSV-1 specific immune responses in atopic dermatitis
CONCLUSION: Our findings suggest that dupilumab may improve the HSV-1-specific immune response in AD due to an increased type I immune response and a reduction of HSV-1-specific IgE.PMID:37660986 | DOI:10.1016/j.jaci.2023.08.024
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Stephan Traidl Leonard Harries Petra Kienlin Gabriele Begemann Lennart M Roesner Thomas Werfel Source Type: research

Dupilumab strengthens herpes simplex virus type 1 –specific immune responses in atopic dermatitis
Atopic dermatitis (AD), one of the most prevalent chronic inflammatory skin diseases, is orchestrated by a complex pathophysiology influenced by the immune system and skin barrier; it is influenced by environmental factors.1 Altered immune response is marked by type 2 inflammation, with a key role for TH2 cells, but it occurs especially in the chronic phase TH1 and TH17 responses as well.2,3 Moderately and severely affected AD patients are particularly prone to bacterial, fungal, and viral infections.
Source: Journal of Allergy and Clinical Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Stephan Traidl, Leonard Harries, Petra Kienlin, Gabriele Begemann, Lennart M. Roesner, Thomas Werfel Source Type: research

Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity from the ADRN Registry
CONCLUSION: In a diverse US AD population, severity was associated with a history of atopic disorders, skin and extracutaneous bacterial and viral infections (by history and physical examination), higher IgE, eosinophilia and allergen sensitization, atopic skin manifestations (i.e., excoriation, hyperlinear palms and ichthyosis), and atopic ocular features (i.e., blepharitis, conjunctivitis, and ectropion) as well as asthma findings (i.e., wheezing). Data from our prospective registry significantly advances our understanding of AD phenotypes and endotypes, which is critical to achieve optimal management.PMID:37182563 | DOI...
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Eric L Simpson Anna De Benedetto Mark Boguniewicz Peck Y Ong Stephanie Lussier Miguel Villarreal Lynda C Schneider Amy S Paller Emma Guttman-Yassky Jon M Hanifin Jonathan M Spergel Kathleen C Barnes Gloria David Briahnna Austin Donald Y M Leung Lisa A Bec Source Type: research

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults
Acta Derm Venereol. 2023 Mar 8;103:adv00882. doi: 10.2340/actadv.v103.4447.ABSTRACTThe majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from both primary and specialty healthcare registries covering the entire Finnish adult population. In total, 124,038 patients were identified (median age 46 years; 68% female) and stratified by disease severity. All regression analyses (median follow-up...
Source: Acta Derm Venereol A... - March 8, 2023 Category: Dermatology Authors: Ville Kiiski Liisa Ukkola-Vuoti Johanna Vikkula Martta Ranta Mariann I Lassenius Jaakko Kopra Source Type: research

The Genetics of Eczema Herpeticum
Clin Rev Allergy Immunol. 2022 Sep 17. doi: 10.1007/s12016-022-08953-x. Online ahead of print.ABSTRACTEczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesions in atopic dermatitis (AD). Though the pathogenesis of EH has yet to be fully elucidated, the fact that EH is relatively rare despite a majority of adults showing serologic evidence of HSV exposure points to a genetic component predisposing to the disease. A number of genetic variants have been isolated in EH which may help distinguish a subgroup of patients susceptible to developing the condition. T...
Source: Herpes - September 17, 2022 Category: Infectious Diseases Authors: Elisabeth Hodara Peck Y Ong Source Type: research

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