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Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression
Conclusion: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.PMID:36116735 | DOI:10.1016/j.bbr.2022.114117
Source: Brain Research - September 18, 2022 Category: Neurology Authors: Xiaoju Wang Peng Xia Jiulong Song Ting Yang Changjun Yu Kai Cheng Anliang Chen Xueping Li Source Type: research

Neuroplasticity and behavioral effects of  fluoxetine after experimental stroke.
Neuroplasticity and behavioral effects of fluoxetine after experimental stroke. Restor Neurol Neurosci. 2017 Aug 24;: Authors: Sun Y, Sun X, Qu H, Zhao S, Xiao T, Zhao C Abstract The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. In clinical practice, fluoxetine alleviates the symptoms of post-stroke depre...
Source: Restorative Neurology and Neuroscience - September 1, 2017 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Depression, Type 2 Diabetes, and Poststroke Cognitive Impairment
Conclusions. Diabetes and depressive symptoms were associated cumulatively with poorer cognitive screening outcomes poststroke, particularly deficits in executive function. Having 1 comorbidity doubled the odds of screening for severe cognitive impairment, having both tripled the odds.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Swardfager, W., MacIntosh, B. J. Tags: Original Research Articles Source Type: research

Epidural Cortical Stimulation as a Treatment for Poststroke Aphasia: A Systematic Review of the Literature and Underlying Neurophysiological Mechanisms
Conclusions. Due to the small number of existing cases in the literature, the strength of the evidence is still low. Two main hypotheses of neurobiological mechanisms have been explored: either using continuous stimulation to modify cortical perilesional inhibition or using intermittent stimulation during the speech and language therapy sessions to explore synaptic plasticity and long-term potentiation or depression. To establish the role of epidural stimulation and the relevant stimulation protocols and parameters, large randomized controlled trials are mandatory. We suggest avenues of investigation.
Source: Neurorehabilitation and Neural Repair - January 27, 2016 Category: Neurology Authors: Balossier, A., Etard, O., Descat, C., Vivien, D., Emery, E. Tags: Clinical Research Articles Source Type: research

Impact of Adapted Physical Activity and Therapeutic Patient Education on Functioning and Quality of Life in Patients With Postacute Strokes
Conclusions. Our results confirm that it is feasible and potentially effective to implement APA programs for elderly patients with complex clinical conditions as early as 3 months after a stroke and suggest that, when combined with TPE, the effects of a postrehabilitation APA program are relatively enduring.
Source: Neurorehabilitation and Neural Repair - September 8, 2014 Category: Neurology Authors: Taricco, M., Dallolio, L., Calugi, S., Rucci, P., Fugazzaro, S., Stuart, M., Pillastrini, P., Fantini, M. P., the EFG [Esercizio Fisico di Gruppo] /2009 Investigators, Taricco, Bassi, Bernucci, Gaudenzi, Kopliku, Manigrasso, Morara, Dallolio, Calugi, Fant Tags: Clinical Research Articles Source Type: research

Dual-Hemisphere Repetitive Transcranial Magnetic Stimulation for Rehabilitation of Poststroke Aphasia: A Randomized, Double-Blind Clinical Trial
Conclusion. This is the first clinical study of dual-hemisphere rTMS in poststroke aphasia. Combining dual-hemisphere rTMS with language training might be a feasible treatment for nonfluent aphasia; further multicenter studies are needed to confirm this result.
Source: Neurorehabilitation and Neural Repair - September 8, 2014 Category: Neurology Authors: Khedr, E. M., Abo El-Fetoh, N., Ali, A. M., El-Hammady, D. H., Khalifa, H., Atta, H., Karim, A. A. Tags: Clinical Research Articles Source Type: research

Impact of BDNF -196 g≯a and BDNF -270 c≯t polymorphisms on stroke rehabilitation outcome: sex and age differences.
Conclusions:BDNF -196 G≯A polymorphism might affect functional outcome of stroke rehabilitation, but this hypothesis needs further verification. PMID: 24722042 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - April 17, 2014 Category: Neurology Authors: Mirowska-Guzel D, Gromadzka G, Mendel T, Janus-Laszuk B, Dzierka J, Sarzynska-Dlugosz I, Czlonkowski A, Czlonkowska A Tags: Top Stroke Rehabil Source Type: research

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