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Sertraline for Functional Recovery After Acute Ischemic Stroke: A Prospective Observational Study
Conclusions: In this non-randomized comparison, early treatment with sertraline tended to favor functional recovery in patients with acute ischemic stroke. While exploratory in nature, this hypothesis needs further investigation in a clinical trial.
Source: Frontiers in Neurology - October 5, 2021 Category: Neurology Source Type: research

Effects of Combined Sertraline and Magnesium in Rat Atrium
The objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10-3 M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertralin...
Source: Biological Trace Element Research - March 28, 2021 Category: Biology Authors: Esra Fidan Z Isik Solak Gormus İbrahim Kilinc Mehmet Sinan İyisoy Niyazi Gormus Source Type: research

Prevention of depression in adults with long-term physical conditions
CONCLUSIONS: Based on evidence of very low certainty, our results may indicate the benefit of pharmacological interventions, during or directly after preventive treatment. Few trials examined short-term outcomes up to six months, nor the follow-up effects at six to 12 months, with studies suffering from great numbers of drop-outs and inconclusive results. Generalisation of results is limited as study populations and treatment regimes were very heterogeneous. Based on the results of this review, we conclude that for adults with long-term physical conditions, there is only very uncertain evidence regarding the implementation...
Source: Cochrane Database of Systematic Reviews - March 5, 2021 Category: General Medicine Authors: Hanna Kampling Harald Baumeister J ürgen Bengel Oskar Mittag Source Type: research

Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research

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