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Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Development of a new GC ‐MS/MS method for the determination of metformin in human hair
AbstractDiabetes mellitus is one of the most important public health challenges. Metformin (1,1 ‐dimethylbiguanide) represents the “gold standard” for the treatment of diabetes mellitus type 2. Despite its important role in reducing mortality and morbidity in the diabetic population, metformin is associated with an increased risk of stroke. To document exposure to a drug, hair is conside red to be the specimen of choice to complement blood and urine, since it provides historical detail of a subject's chronic exposure to drug(s). Measuring hair concentration of metformin can be important for forensic toxicologists inv...
Source: Drug Testing and Analysis - May 28, 2020 Category: Drugs & Pharmacology Authors: Nadia Arbouche, Marie ‐Odile Batt, Jean‐Sebastien Raul, Pascal Kintz Tags: SHORT COMMUNICATION Source Type: research

Development of a new GC –MS/MS method for the determination of metformin in human hair
In this study the authors have developed a GC/MS–MS method for the detection and the quantification of metformin in human hair and have applied it to patients under treatment. Measured concentrations range from 0.3 to 3.8 ng/mg. Me tformin appears to be poorly incorporated into hair, given a daily dose of 1 to 3 g. There is probably a correlation between dose and concentration in dark hair. AbstractDiabetes mellitus is one of the most important public health challenges. Metformin (1,1 ‐dimethylbiguanide) represents the “gold standard” for the treatment of diabetes mellitus type 2. Despite its important role in redu...
Source: Drug Testing and Analysis - June 27, 2020 Category: Drugs & Pharmacology Authors: Nadia Arbouche, Marie ‐Odile Batt, Jean‐Sebastien Raul, Pascal Kintz Tags: SHORT COMMUNICATION Source Type: research