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Condition: Poisoning
Drug: Acetylcysteine
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Total 134 results found since Jan 2013.
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning
We reported a case of a 15-year- old girl referred to our Emergency Department 3 hours after ingestion of 10 g of paracetamol for suicidal purposes. She promptly started the administration of intravenous N-acetylcysteine (NAC) and the patient was discharged after 5 days of hospitalization in good clinical condition and with neuropsychiatric follow-up. Our case shows that the timing of the intravenous NAC administration is considered the most important factor in the prevention of acetaminophen-induced hepatic failure, despite high serum levels after acetaminophen ingestion.PMID:37247196 | DOI:10.23750/abm.v94iS1.13714
Source: Acta Bio-Medica : Atenei Parmensis - May 29, 2023 Category: General Medicine Authors: Serena Ferretti Antonietta Curatola Antonio Chiaretti Benedetta Graglia Antonio Gatto Lavinia Capossela Valeria Pansini Source Type: research
Management of Poisonings and Intoxications
Clin J Am Soc Nephrol. 2023 Jan 13. doi: 10.2215/CJN.0000000000000057. Online ahead of print.ABSTRACTPoisoning occurs after exposure to any of a number of substances, including medicines, which can result in severe toxicity including death. The nephrologist may be involved in poisonings that cause kidney disease and for targeted treatments. The overall approach to the poisoned patient involves the initial acute resuscitation and performing a risk assessment, whereby the exposure is considered in terms of the anticipated severity and in the context of the patient's status and treatments that may be required. Time-critical i...
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 25, 2023 Category: Urology & Nephrology Authors: Marc Ghannoum Darren M Roberts Source Type: research
From the forest to the ICU and back: an investigative work-up of Amanita phalloides poisoning
We present the case of a 32-year-old patient who presented with acute liver failure after Amanita phalloides (green death cap mushroom) ingestion and whose therapeutic success was significantly influenced by the administration of activated charcoal, silibinin, and N-acetylcysteine as well as the determined research of an external mycologist.In various retrospective studies, a relevant reduction of mortality could be shown by the mentioned medicinal measures. Despite the high estimated amount of ingestion, we could confirm the effectiveness of this combination therapy in this case.Here, in addition to the drug therapy, atte...
Source: Zeitschrift fur Gastroenterologie - March 27, 2023 Category: Gastroenterology Authors: Mohamad Murad Teresa M Anslinger Daniel Frank Philipp Hohlstein Liette van den Burg Jonathan Frederik Brozat Maike R Pollmanns Malin Fromme Marie Gr ünert Richard Lubberich Theresa H Wirtz Karim Hamesch Christian Trautwein Samira Abu Jhaisha Alexander Ko Source Type: research
Acetaminophen metabolites on presentation following an acute acetaminophen overdose (ATOM-7)
This study found that those who developed hepatotoxicity had higher acetaminophen metabolites derived from CYP pathway and lower sulfation metabolite on presentation. Acetaminophen metabolites may be utilised in the future to identify patients who could benefit from increased acetylcysteine or newer adjunct or research therapies.PMID:36919638 | DOI:10.1002/cpt.2888
Source: Clinical Pharmacology and Therapeutics - March 15, 2023 Category: Drugs & Pharmacology Authors: Angela L Chiew Geoffrey K Isbister Paul Stathakis Katherine Z Isoardi Colin Page Kirsty Ress Betty Sh Chan Nicholas A Buckley Source Type: research
Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity
CONCLUSION AND RELEVANCE: A significant decrease in cutaneous NAARs and MEs was observed in pediatric patients by combining the first two bags of the traditional three-bag NAC regimen. In pediatric populations, a two-bag NAC regimen for acetaminophen overdose may improve medication tolerance and safety.PMID:35587124 | DOI:10.1177/10600280221097700
Source: The Annals of Pharmacotherapy - May 19, 2022 Category: Drugs & Pharmacology Authors: Sindhu Sudanagunta Alexa Camarena-Michel Stephanie Pennington Jan Leonard Christopher Hoyte George Sam Wang Source Type: research
Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor
CONCLUSIONS: MSCs are comparable to NAC against APAP-induced liver failure by secreting HGF with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.PMID:35246254 | DOI:10.1186/s13287-022-02754-x
Source: Cell Research - March 5, 2022 Category: Cytology Authors: Ping Wang Yan Cui Jing Wang Donghua Liu Yue Tian Kai Liu Xue Wang Lin Liu Yu He Yufeng Pei Li Li Liying Sun Zhijun Zhu Dehua Chang Jidong Jia Hong You Source Type: research
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Arch Toxicol. 2022 Jan 3. doi: 10.1007/s00204-021-03211-z. Online ahead of print.ABSTRACTAcetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion. However, for late-presenting patients or after ingestion of very large overdoses, the efficacy of NAC is diminished. Thus, additional antidotes with an extended therapeutic window may be nee...
Source: Archives of Toxicology - January 3, 2022 Category: Toxicology Authors: Jephte Y Akakpo Anup Ramachandran Steven C Curry Barry H Rumack Hartmut Jaeschke Source Type: research
